1. Single-cell brain organoid screening identifies developmental defects in autism 

   Li C.; Fleck J.S.; Martins-Costa C.; et al. (2023)

   Nature

   The development of the human brain involves unique processes (not observed in many other species) that can contribute to neurodevelopmental disorders1-4. Cerebral organoids enable the study of neurodevelopmental disorders in a human context. We have developed the CRISPR-human organoids-single-cell RNA sequencing (CHOOSE) system, which uses verified pairs of guide RNAs, inducible CRISPR-Cas9-based genetic disruption and single-cell ...

   Journal Article

2. Enhancing Water Safety in Decentralized Water Reuse Systems with Low-Cost Prussian Blue Amperometric Sensors for Free Chlorine Monitoring 

   Herold G.; Rodino F.; Golparvar A.; et al. (2023)

   IEEE Sensors Letters

   The challenge of providing sustainable and safe water services in regions lacking centralized water infrastructure can be addressed through the utilization of on-site treatment and reuse of wastewater. However, the widespread implementation of decentralized water reuse systems is currently hindered by the considerable expenses associated with remote water quality monitoring. Specifically, when using chlorination for treatment, the fabrication ...

   Journal Article

3. Three-Dimensional Modeling of the Ground Electric Field in Fennoscandia During the Halloween Geomagnetic Storm 

   Marshalko E.; Kruglyakov M.; Kuvshinov A.; et al. (2023)

   Space Weather

   In this study, we perform three-dimensional (3-D) ground electric field (GEF) modeling in Fennoscandia for three days of the Halloween geomagnetic storm (29–31 October 2003) using magnetic field data from the International Monitor for Auroral Geomagnetic Effects (IMAGE) magnetometer network and a 3-D conductivity model of the region. To explore the influence of the inducing source model on 3-D GEF simulations, we consider three different ...

   Journal Article

4. Doubling the coating-substrate pull-off strength by growth of CaCO<inf>3</inf> nano-crystals 

   Dai Y.; Lan Y.; Wen R.; et al. (2023)

   Chemical Engineering Journal

   Strong coating-substrate adhesion is crucial for ensuring long-term durability and performance of protective coatings in various applications. The growth of nano crystals on the substrate may be a preferable way to enhance the coating-substrate interactions. Here, an accelerated carbonation curing (ACC) scheme (0.5 MPa CO2 gas pressure) was designed to grow calcium carbonate (CaCO3) nano-crystals on a mortar substrate at early age before ...

   Journal Article

5. Late-Stage Molecular Editing Enabled by Ketone Chain-Walking Isomerization 

   Brägger Y.; Green O.; Bhawal B.N.; et al. (2023)

   Journal of the American Chemical Society

   Herein, a method for the isomerization of ketones in a manner akin to the chain-walking reaction of alkenes is described. Widely available and inexpensive pyrrolidine and elemental sulfur are deployed as catalysts to achieve this reversible transformation. Key to the utility of this approach was the elucidation of a stereochemical model to determine the thermodynamically favored product of the reaction and the kinetic selectivity observed. ...

   Journal Article

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