Journal: Biomechanics and Modeling in Mechanobiology

Abbreviation

Biomech Model Mechanobiol

Publisher

Springer

Journal Volumes

ISSN

1617-7959
1617-7940

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Publications 1 - 10 of 32
  • Modelling evolution and the evolving mechanical environment of saccular cerebral aneurysms
    Item type: Journal Article
    Watton, P.N.; Selimovic, A.; Raberger, N.B.; et al. (2011)
    Biomechanics and Modeling in Mechanobiology
  • Visco- and poroelastic contributions of the zona pellucida to the mechanical response of oocytes
    Item type: Journal Article
    Stracuzzi, Alberto; Dittmann, Johannes; Böl, Markus; et al. (2021)
    Biomechanics and Modeling in Mechanobiology
    Probing mechanical properties of cells has been identified as a means to infer information on their current state, e.g. with respect to diseases or differentiation. Oocytes have gained particular interest, since mechanical parameters are considered potential indicators of the success of in vitro fertilisation procedures. Established tests provide the structural response of the oocyte resulting from the material properties of the cell’s components and their disposition. Based on dedicated experiments and numerical simulations, we here provide novel insights on the origin of this response. In particular, polarised light microscopy is used to characterise the anisotropy of the zona pellucida, the outermost layer of the oocyte composed of glycoproteins. This information is combined with data on volumetric changes and the force measured in relaxation/cyclic, compression/indentation experiments to calibrate a multi-phasic hyper-viscoelastic model through inverse finite element analysis. These simulations capture the oocyte’s overall force response, the distinct volume changes observed in the zona pellucida, and the structural alterations interpreted as a realignment of the glycoproteins with applied load. The analysis reveals the presence of two distinct timescales, roughly separated by three orders of magnitude, and associated with a rapid outflow of fluid across the external boundaries and a long-term, progressive relaxation of the glycoproteins, respectively. The new results allow breaking the overall response down into the contributions from fluid transport and the mechanical properties of the zona pellucida and ooplasm. In addition to the gain in fundamental knowledge, the outcome of this study may therefore serve an improved interpretation of the data obtained with current methods for mechanical oocyte characterisation.
  • Experimental and finite element analysis of the mouse caudal vertebrae loading model: prediction of cortical and trabecular bone adaptation
    Item type: Journal Article
    Webster, Duncan; Wirth, Andreas; van Lenthe, G. Harry; et al. (2012)
    Biomechanics and Modeling in Mechanobiology
  • Modeling microdamage behavior of cortical bone
    Item type: Journal Article
    Donaldson, Finn; Ruffoni, Davide; Schneider, Philipp; et al. (2014)
    Biomechanics and Modeling in Mechanobiology
    Bone is a complex material which exhibits several hierarchical levels of structural organization. At the submicron-scale, the local tissue porosity gives rise to discontinuities in the bone matrix which have been shown to influence damage behavior. Computational tools to model the damage behavior of bone at different length scales are mostly based on finite element (FE) analysis, with a range of algorithms developed for this purpose. Although the local mechanical behavior of bone tissue is influenced by microstructural features such as bone canals and osteocyte lacunae, they are often not considered in FE damage models due to the high computational cost required to simulate across several length scales, i.e., from the loads applied at the organ level down to the stresses and strains around bone canals and osteocyte lacunae. Hence, the aim of the current study was twofold: First, a multilevel FE framework was developed to compute, starting from the loads applied at the whole bone scale, the local mechanical forces acting at the micrometer and submicrometer level. Second, three simple microdamage simulation procedures based on element removal were developed and applied to bone samples at the submicrometer-scale, where cortical microporosity is included. The present microdamage algorithm produced a qualitatively analogous behavior to previous experimental tests based on stepwise mechanical compression combined with in situ synchrotron radiation computed tomography. Our results demonstrate the feasibility of simulating microdamage at a physiologically relevant scale using an image-based meshing technique and multilevel FE analysis; this allows relating microdamage behavior to intracortical bone microstructure.
  • Multiaxial mechanical behavior of human fetal membranes and its relationship to microstructure
    Item type: Journal Article
    Buerzle, W.; Haller, C. M.; Jabareen, M.; et al. (2013)
    Biomechanics and Modeling in Mechanobiology
  • Use of micro-CT-based finite element analysis to accurately quantify peri-implant bone strains
    Item type: Journal Article
    Torcasio, Antonia; Zhang, Xiaolei; Oosterwyck, Hans van; et al. (2012)
    Biomechanics and Modeling in Mechanobiology
  • Geometrical aspects of patient specific modelling of the intervertebral disc: Collagen fibre orientation and residual stress distribution
    Item type: Journal Article
    Marini, Giacomo; Studer, Harald; Huber, Gerd; et al. (2016)
    Biomechanics and Modeling in Mechanobiology
  • Simulated tissue growth for 3D printed scaffolds
    Item type: Journal Article
    Egan, Paul F.; Shea, Kristina A.; Ferguson, Stephen J. (2018)
    Biomechanics and Modeling in Mechanobiology
    Experiments have demonstrated biological tissues grow by mechanically sensing their localized curvature, therefore making geometry a key consideration for tissue scaffold design. We developed a simulation approach for modeling tissue growth on beam-based geometries of repeating unit cells, with four lattice topologies considered. In simulations, tissue was seeded on surfaces with new tissue growing in empty voxels with positive curvature. Growth was fastest on topologies with more beams per unit cell when unit cell volume/porosity was fixed, but fastest for topologies with fewer beams per unit cell when beam width/porosity was fixed. Tissue filled proportional to mean positive surface curvature per volume. Faster filling scaffolds had lower permeability, which is important to support nutrient transport, and highlights a need for tuning geometries appropriately for conflicting trade-offs. A balance among trade-offs was found for scaffolds with beam diameters of about 300μm and 50% porosity, therefore providing the opportunity for further optimization based on criteria such as mechanical factors. Overall, these findings provide insight into how curvature-based tissue growth progresses in complex scaffold geometries, and a foundation for developing optimized scaffolds for clinical applications.
  • A novel experimental procedure based on pure shear testing of dermatome-cut samples applied to porcine skin
    Item type: Journal Article
    Hollenstein, Marc; Ehret, Alexander E.; Itskov, Mikhail; et al. (2011)
    Biomechanics and Modeling in Mechanobiology
  • A quadriphasic mechanical model of the human dermis
    Item type: Journal Article
    Sachs, David; Jakob, Raphael; Restivo, Gaetana; et al. (2024)
    Biomechanics and Modeling in Mechanobiology
    The present study investigates the multiphasic nature of the mechanical behavior of human dermis. Motivated by experimental observations and by consideration of its composition, a quadriphasic model of the dermis is proposed, distinguishing solid matrix components, interstitial fluid and charged constituents moving within the fluid, i.e., anions and cations. Compression and tensile experiments with and without change of osmolarity of the bath are performed to characterize the chemo-mechanical coupling in the dermis. Model parameters are determined through inverse analysis. The computations predict a dominant role of the permeability in the determination of the temporal evolution of the mechanical response of the tissue. In line with the previous studies on other tissues, the analysis shows that an ideal model based on Donnan's equilibrium overestimates the osmotic pressure in skin for the case of very dilute solutions. The quadriphasic model is applied to predict changes in dermal cell environment and therefore alterations in what is called the "mechanome," associated with skin stretch. The simulations indicate that skin deformation causes a variation in several local variables, including in particular the electric field associated with a deformation-induced non-homogeneous distribution of fixed charges.
Publications 1 - 10 of 32