Neurobiology of Learning and Memory

Journal: Neurobiology of Learning and Memory

Abbreviation

Neurobiol. Learn. Mem.

Publisher

Elsevier

ISSN

1074-7427
1095-9564

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Publications 1 - 10 of 10

Forebrain glycine transporter 1 deletion enhances sensitivity to CS-US discontiguity in classical conditioning
Singer, P.; Dubroqua, S.; Yee, B.K. (2014)
Neurobiology of Learning and Memory
The nuclear matrix protein Matr3 regulates processing of the synaptic microRNA-138-5p
Weiss, Kerstin; Treiber, Thomas; Meister, Gunter; et al. (2019)
Neurobiology of Learning and Memory
The involvement of epigenetic defects in mental retardation
Franklin, Tamara B.; Mansuy, Isabelle (2011)
Neurobiology of Learning and Memory
Hippocampal α5 subunit-containing GABAA receptors are involved in the development of the latent inhibition effect
Gerdjikov, T.V.; Rudoplh, U.; Keist, R.; et al. (2008)
Neurobiology of Learning and Memory
Cognitive effects of subdiaphragmatic vagal deafferentation in rats
Klarer, Melanie; Weber-Stadlbauer, Ulrike; Arnold, Myrtha; et al. (2017)
Neurobiology of Learning and Memory
Nogo-A downregulation impairs place avoidance in the Carousel maze but not spatial memory in the Morris water maze
Petrasek, Tomas; Prokopova, Iva; Bahnik, Stepan; et al. (2014)
Neurobiology of Learning and Memory
Placebo-mediated, Naloxone-sensitive suggestibility of short-term memory performance
Stern, Jair; Candia, Victor; Porchet, Roseline I.; et al. (2011)
Neurobiology of Learning and Memory
Physiological studies of placebo-mediated suggestion have been recently performed beyond their traditional clinical context of pain and analgesia. Various neurotransmitter systems and immunological modulators have been used in successful placebo suggestions, including Dopamine, Cholecystokinin and, most extensively, opioids. We adhered to an established conceptual framework of placebo research and used the μ-opioid-antagonist Naloxone to test the applicability of this framework within a cognitive domain (e.g. memory) in healthy volunteers. Healthy men (n = 62, age 29, SD = 9) were required to perform a task-battery, including standardized and custom-designed memory tasks, to test short-term recall and delayed recognition. Tasks were performed twice, before and after intravenous injection of either NaCl (0.9%) or Naloxone (both 0.15 mg/kg), in a double-blind setting. While one group was given neutral information (S−), the other was told that it might receive a drug with suspected memory-boosting properties (S+). Objective and subjective indexes of memory performance and salivary cortisol (as a stress marker) were recorded during both runs and differences between groups were assessed. Short-term memory recall, but not delayed recognition, was objectively increased after placebo-mediated suggestion in the NaCl-group. Naloxone specifically blocked the suggestion effect without interfering with memory performance. These results were not affected when changes in salivary cortisol levels were considered. No reaction time changes, recorded to uncover unspecific attentional impairment, were seen. Placebo-mediated suggestion produced a training-independent, objective and Naloxone-sensitive increase in memory performance. These results indicate an opioid-mediated placebo effect within a circumscribed cognitive domain in healthy volunteers.
Transient activation of the CA3 Kappa opioid system in the dorsal hippocampus modulates complex memory processing in mice
Daumas, Stéphanie; Betourne, Alexandre; Halley, Hélène; et al. (2007)
Neurobiology of Learning and Memory
The hippocampus plays a central role in various forms of complex learning and memory. Opioid peptides and receptors are abundant in the hippocampus. These peptides are co-released with glutamate from mossy fiber- and lateral perforant path-synapses. In this study, we evaluated the functional relevance of the CA3 Kappa opioid receptors (KOR) by transient pharmacological activation or inactivation using single bilateral intrahippocampal microinjections of a selective agonist (U50,488H, 1 or 2.5 nmol), a selective antagonist (nor-binaltorphimine, norBNI 5 nmol) or a mixture of both. C57Bl/6J mice were tested in a fear conditioning paradigm (FC) or in a modified version of the water maze task thought to reveal how flexibly animals can learn and manipulate spatial information (WM). In FC, the agonist (2.5 nmol) decreased context-induced (but not tone-induced) freezing whereas norBNI had no effect. The impairment caused by the agonist U50,488H was blocked by the injection of norBNI, suggesting that overstimulation of CA3-KOR impairs the acquisition and consolidation of contextual fear-related memory. In the WM task, mice were trained repeatedly each day to find a hidden platform. After having reached this goal, the platform position was changed the next day for a new task. U50,488H injection before the last task abolished the previously acquired ability to find rapidly a new platform location, whereas adding norBNI reversed this impairment. Thus, in the mouse, even partial and topographically restricted activation of CA3-KOR entails impairments in two different hippocampus-dependent tasks, indicating functional relevance of the kappa opioid system.
The memory gene KIBRA is a bidirectional regulator of synaptic and structural plasticity in the adult brain
Heitz, Fabrice D.; Farinelli, Mélissa; Mohanna, Safa; et al. (2016)
Neurobiology of Learning and Memory
Examining the sex- and circadian dependency of a learning phenotype in mice with glycine transporter 1 deletion in two Pavlovian conditioning paradigms
Dubroqua, Sylvain; Boison, Detlev; Feldon, Joram; et al. (2011)
Neurobiology of Learning and Memory

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