Integrative Biology

Journal: Integrative Biology

Abbreviation

Integr. biol. (Print)

Publisher

Royal Society of Chemistry

ISSN

1757-9694
1757-9708

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Publications 1 - 10 of 27

Engineered 3D environments to elucidate the effect of environmental parameters on drug response in cancer
Hakanson, Maria; Textor, Marcus; Charnley, Mirren (2011)
Integrative Biology
Integration column
Charnley, Mirren; Textor, Marcus; Khademhosseini, Ali; et al. (2009)
Integrative Biology
Engineering 3D cell instructive microenvironments by rational assembly of artificial extracellular matrices and cell patterning
Sala, Ana; Hänseler, Patrick; Ranga, Adrian; et al. (2011)
Integrative Biology
A facile protocol for the immobilisation of vesicles, virus particles, bacteria, and yeast cells
Kuhn, Philipp; Eyer, Klaus; Robinson, Tom; et al. (2012)
Integrative Biology
Cell Image Velocimetry (CIV)
Milde, Florian; Franco, Davide; Ferrari, Aldo; et al. (2012)
Integrative Biology
Large-scale analysis of neurite growth dynamics on micropatterned substrates
Wissner-Gross, Zachary D.; Scott, Mark A.; Ku, David; et al. (2010)
Integrative Biology
Influence of applied currents on the viability of cells close to microelectrodes
Gabi, Michael; Sannomiya, Takumi; Larmagnac, Alexandre; et al. (2009)
Integrative Biology
Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade
Sharifian, Hoda; Lampert, Fabienne; Stojanovski, Klement; et al. (2015)
Integrative Biology
Tight regulation of the MAP kinase Hog1 is crucial for survival under changing osmotic conditions. Interestingly, we found that Hog1 phosphorylates multiple upstream components, implying feedback regulation within the signaling cascade. Taking advantage of an unexpected link between glucose availability and Hog1 activity, we used quantitative single cell measurements and computational modeling to unravel feedback regulation operating in addition to the well-known adaptation feedback triggered by glycerol accumulation. Indeed, we found that Hog1 phosphorylates its activating kinase Ssk2 on several sites, and cells expressing a non-phosphorylatable Ssk2 mutant are partially defective for feedback regulation and proper control of basal Hog1 activity. Together, our data suggest that Hog1 activity is controlled by intertwined regulatory mechanisms operating with varying kinetics, which together tune the Hog1 response to balance basal Hog1 activity and its steady-state level after adaptation to high osmolarity.
The mouse retina in 3D
Milde, Florian; Lauw, Stephanie; Koumoutsakos, Petros; et al. (2013)
Integrative Biology
Probing bacterial-fungal interactions at the single cell level
Stanley, Claire E.; Stöckli, Martina; Swaay, Dirk van; et al. (2014)
Integrative Biology

Publications 1 - 10 of 27

Journal: Integrative Biology

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