Pharmaceutical Research

Journal: Pharmaceutical Research

Abbreviation

Pharm. res.

Publisher

Springer

ISSN

0724-8741
1573-904X

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Publications1 - 10 of 29

The pH-Dependence in the Partitioning Behaviour of (RS)-[3H]Propranolol Between MDCK Cell Lipid Vesicles and Buffer
Krämer, Stefanie-Dorothea; Wunderli-Allenspach, Heidi (1996)
Pharmaceutical Research
Isolated rafts from adriamycin-resistant P388 cells contain functional ATPases and provide an easy test system for P Glycoprotein-related activities
Bucher, Karsten; Besse, Camille A.; Kamau, Sarah W.; et al. (2005)
Pharmaceutical Research
Effect of oil-in-water emulsions on 5-aminolevulinic acid uptake and metabolism to PpIX in cultured MCF-7 cells
Mørck Nielsen, Hanne; Aemisegger, Caroline; Burchard, Gerd; et al. (2004)
Pharmaceutical Research
Insulin-like growth factor I-releasing alginate-tricalciumphosphate composites for bone regeneration
Luginbuehl, Vera; Wenk, Esther; Koch, Annette; et al. (2005)
Pharmaceutical Research
Magnetic resonance imaging for the in vivo evaluation of gastric-retentive tablets
Steingoetter, Andreas; Weishaupt, Dominik; Kunz, Patrick; et al. (2003)
Pharmaceutical Research
Cellular Internalization of Human Calcitonin Derived Peptides in MDCK Monolayers
Tréhin, Rachel; Krauss, Ulrike; Muff, Roman; et al. (2004)
Pharmaceutical Research
On Technological and Immunological Benefits of Multivalent Single-Injection Microsphere Vaccines
Boehm, Gérard; Peyre, Marisa; Sesardic, Dorothea; et al. (2002)
Pharmaceutical Research
Permeation Studies In Vitro and In Vivo of Potential Radiopharmaceuticals with Affinity to Neuro Receptors
Friebe, Matthias; Suda, Kayoshi; Spies, Hartmut; et al. (2000)
Pharmaceutical Research
Improving the Stability and Activity of Oral Therapeutic Enzymes—Recent Advances and Perspectives
Fuhrmann, Gregor; Leroux, Jean-Christophe (2014)
Pharmaceutical Research
Exogenous, orally-administered enzymes are currently in clinical use or under development for the treatment of pathologies, such as celiac disease and phenylketonuria. However, the administration of therapeutic enzymes via the oral route remains challenging due to potential inactivation of these fragile macromolecular entities in the harsh environment of the gastrointestinal tract. Enzymes are particularly sensitive because both proteolysis and unfolding can lead to their inactivation. Current efforts to overcome these shortcomings involve the application of gastro-resistant delivery systems and the modification of enzyme structures by polymer conjugation or protein engineering. This perspective manuscript reviews and critically discusses recent progress in the oral delivery of therapeutic enzymes, whose substrate is localized in the gastrointestinal tract.
Ligand-specific targeting of microspheres to phagocytes by surface modification with poly(L-lysine)-grafted poly(ethylene glycol) conjugate
Faraasen, Sofia; Vörös, Janos; Csúcs, Gábor; et al. (2003)
Pharmaceutical Research

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