Journal: Advanced Materials

Abbreviation

Adv Mater

Publisher

Wiley

Journal Volumes

ISSN

0935-9648
1521-4095

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Publications1 - 10 of 63
  • Nanoscale Guiding of Infrared Light with Hyperbolic Volume and Surface Polaritons in van der Waals Material Ribbons
    Item type: Journal Article
    Dolado, Irene; Alfaro-Mozaz, Francisco Javier; Li, Peining; et al. (2020)
    Advanced Materials
  • Optimized Photoclick (Bio)Resins for Fast Volumetric Bioprinting
    Item type: Journal Article
    Rizzo, Riccardo; Ruetsche, Dominic; Liu, Hao; et al. (2021)
    Advanced Materials
    Volumetric printing (VP) is a light-mediated technique enabling printing of complex, low-defect 3D objects within seconds, overcoming major drawbacks of layer-by-layer additive manufacturing. An optimized photoresin is presented for VP in the presence of cells (volumetric bioprinting) based on fast thiol-ene step-growth photoclick crosslinking. Gelatin-norbornene (Gel-NB) photoresin shows superior performance, both in physicochemical and biocompatibility aspects, compared to (meth-)acryloyl resins. The extremely efficient thiol-norbornene reaction produces the fastest VP reported to date (approximate to 10 s), with significantly lower polymer content, degree of substitution (DS), and radical species, making it more suitable for cell encapsulation. This approach enables the generation of cellular free-form constructs with excellent cell viability (approximate to 100%) and tissue maturation potential, demonstrated by development of contractile myotubes. Varying the DS, polymer content, thiol-ene ratio, and thiolated crosslinker allows fine-tuning of mechanical properties over a broad stiffness range (approximate to 40 Pa to approximate to 15 kPa). These properties are achieved through fast and scalable methods for producing Gel-NB with inexpensive, off-the-shelf reagents that can help establish it as the gold standard for light-mediated biofabrication techniques. With potential applications from high-throughput bioprinting of tissue models to soft robotics and regenerative medicine, this work paves the way for exploitation of VPs unprecedented capabilities.
  • Terahertz Spin‐to‐Charge Conversion by Interfacial Skew Scattering in Metallic Bilayers
    Item type: Journal Article
    Gueckstock, Oliver; Nádvorník, Lukáš; Gradhand, Martin; et al. (2021)
    Advanced Materials
    The efficient conversion of spin to charge transport and vice versa is of major relevance for the detection and generation of spin currents in spin‐based electronics. Interfaces of heterostructures are known to have a marked impact on this process. Here, terahertz (THz) emission spectroscopy is used to study ultrafast spin‐to‐charge‐current conversion (S2C) in about 50 prototypical F|N bilayers consisting of a ferromagnetic layer F (e.g., Ni81Fe19, Co, or Fe) and a nonmagnetic layer N with strong (Pt) or weak (Cu and Al) spin‐orbit coupling. Varying the structure of the F/N interface leads to a drastic change in the amplitude and even inversion of the polarity of the THz charge current. Remarkably, when N is a material with small spin Hall angle, a dominant interface contribution to the ultrafast charge current is found. Its magnitude amounts to as much as about 20% of that found in the F|Pt reference sample. Symmetry arguments and first‐principles calculations strongly suggest that the interfacial S2C arises from skew scattering of spin‐polarized electrons at interface imperfections. The results highlight the potential of skew scattering for interfacial S2C and propose a promising route to enhanced S2C by tailored interfaces at all frequencies from DC to terahertz.
  • Morphogenesis Guided by 3D Patterning of Growth Factors in Biological Matrices
    Item type: Journal Article
    Broguiere, Nicolas; Lüchtefeld, Ines; Trachsel, Lucca; et al. (2020)
    Advanced Materials
    Three‐dimensional (3D) control over the placement of bioactive cues is fundamental to understand cell guidance and develop engineered tissues. Two‐photon patterning (2PP) provides such placement at micro‐ to millimeter scale, but nonspecific interactions between proteins and functionalized extracellular matrices (ECMs) restrict its use. Here, a 2PP system based on nonfouling hydrophilic photocages and Sortase A (SA)‐based enzymatic coupling is presented, which offers unprecedented orthogonality and signal‐to‐noise ratio in both inert hydrogels and complex mammalian matrices. Improved photocaged peptide synthesis and protein functionalization protocols with broad applicability are introduced. Importantly, the method enables 2PP in a single step in the presence of fragile biomolecules and cells, and is compatible with time‐controlled growth factor presentation. As a corollary, the guidance of axons through 3D‐patterned nerve growth factor (NGF) within brain‐mimetic ECMs is demonstrated. The approach allows for the interrogation of the role of complex signaling molecules in 3D matrices, thus helping to better understand biological guidance in tissue development and regeneration.
  • Solution-Processable Near-IR Photodetectors Based on Electron Transfer from PbS Nanocrystals to Fullerene Derivatives
    Item type: Journal Article
    Szendrei, Krisztina; Cordella, Fabrizio; Kovalenko, Maksym V.; et al. (2009)
    Advanced Materials
  • Small-Scale Machines Driven by External Power Sources
    Item type: Journal Article
    Chen, Xiang-Zhong; Jang, Bumjin; Ahmed, Daniel; et al. (2018)
    Advanced Materials
  • 3D Plate‐Lattices: An Emerging Class of Low‐Density Metamaterial Exhibiting Optimal Isotropic Stiffness
    Item type: Journal Article
    Tancogne-Dejean, Thomas; Diamantopoulou, Marianna; Gorji, Maysam B.; et al. (2018)
    Advanced Materials
  • Functional Materials from Nanocellulose: Utilizing Structure-Property Relationships in Bottom-Up Fabrication
    Item type: Review Article
    De France, Kevin; Zeng, Zhihui; Wu, Tingting; et al. (2021)
    Advanced Materials
    It is inherently challenging to recapitulate the precise hierarchical architectures found throughout nature (such as in wood, antler, bone, and silk) using synthetic bottom-up fabrication strategies. However, as a renewable and naturally sourced nanoscale building block, nanocellulose—both cellulose nanocrystals and cellulose nanofibrils—has gained significant research interest within this area. Altogether, the intrinsic shape anisotropy, surface charge/chemistry, and mechanical/rheological properties are some of the critical material properties leading to advanced structure-based functionality within nanocellulose-based bottom-up fabricated materials. Herein, the organization of nanocellulose into biomimetic-aligned, porous, and fibrous materials through a variety of fabrication techniques is presented. Moreover, sophisticated material structuring arising from both the alignment of nanocellulose and via specific process-induced methods is covered. In particular, design rules based on the underlying fundamental properties of nanocellulose are established and discussed as related to their influence on material assembly and resulting structure/function. Finally, key advancements and critical challenges within the field are highlighted, paving the way for the fabrication of truly advanced materials from nanocellulose.
  • Stretchable Soft Composites with Strain-Induced Architectured Color
    Item type: Journal Article
    Poloni, Erik; Rafsanjani, Ahmad; Place, Vadim; et al. (2022)
    Advanced Materials
    Colors enable interaction and communication between living species in a myriad of biological and artificial environments. While living organisms feature low-power mechanisms to dynamically control color in soft tissues, man-made color-changing devices remain predominantly rigid and energy intensive. Here, architectured composites that display striking color changes when stretched in selective directions under ambient light with minimum power input are reported. The orientation-dependent color change results from the rotation of reflective coated platelets that are embedded in a soft polymer matrix and pre-aligned in a well-defined architecture. The light reflected by the platelets generates structural color defined by the oxide coating on the platelet surface. By magnetically programming the initial orientation and spatial distribution of selected platelets within the soft matrix, composites with strain-modulated color-changing effects that cannot be achieved using state-of-the-art technologies are created. The proposed concept of strain-induced architectured color can be harnessed to develop low-power smart stretchable displays, tactile synthetic skins, and autonomous soft robotic devices that undergo fast and reversible color changes through the mechano-optic coupling programmed within their soft composite architecture.
  • Hydrogel-Based Slow Release of a Receptor-Binding Domain Subunit Vaccine Elicits Neutralizing Antibody Responses Against SARS-CoV-2
    Item type: Journal Article
    Gale, Emily C.; Powell, Abigail E.; Roth, Gillie A.; et al. (2021)
    Advanced Materials
    The development of effective vaccines that can be rapidly manufactured and distributed worldwide is necessary to mitigate the devastating health and economic impacts of pandemics like COVID-19. The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, which mediates host cell entry of the virus, is an appealing antigen for subunit vaccines because it is efficient to manufacture, highly stable, and a target for neutralizing antibodies. Unfortunately, RBD is poorly immunogenic. While most subunit vaccines are commonly formulated with adjuvants to enhance their immunogenicity, clinically-relevant adjuvants Alum, AddaVax, and CpG/Alum are found unable to elicit neutralizing responses following a prime-boost immunization. Here, it has been shown that sustained delivery of an RBD subunit vaccine comprising CpG/Alum adjuvant in an injectable polymer-nanoparticle (PNP) hydrogel elicited potent anti-RBD and anti-spike antibody titers, providing broader protection against SARS-CoV-2 variants of concern compared to bolus administration of the same vaccine and vaccines comprising other clinically-relevant adjuvant systems. Notably, a SARS-CoV-2 spike-pseudotyped lentivirus neutralization assay revealed that hydrogel-based vaccines elicited potent neutralizing responses when bolus vaccines did not. Together, these results suggest that slow delivery of RBD subunit vaccines with PNP hydrogels can significantly enhance the immunogenicity of RBD and induce neutralizing humoral immunity.
Publications1 - 10 of 63