Journal: EMBO Reports

Abbreviation

EMBO rep.

Publisher

Wiley

Journal Volumes

ISSN

1469-221X
1469-3178

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Publications 1 - 10 of 21
  • Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase
    Item type: Journal Article
    Mithoe, Sharon C.; Ludwig, Christina; Pel, Michiel J.C.; et al. (2016)
    EMBO Reports
  • Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation
    Item type: Journal Article
    Abreu, Susana; Kriegenburg, Franziska; Gómez-Sánchez, Rubén; et al. (2017)
    EMBO Reports
  • Non-apoptotic TRAIL function modulates NK cell activity during viral infection
    Item type: Journal Article
    Alves, Ludmila C.; Berger, Michael D.; Koutsandreas, Thodoris; et al. (2020)
    EMBO Reports
    The role of death receptor signaling for pathogen control and infection‐associated pathogenesis is multifaceted and controversial. Here, we show that during viral infection, tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) modulates NK cell activity independently of its pro‐apoptotic function. In mice infected with lymphocytic choriomeningitis virus (LCMV), Trail deficiency led to improved specific CD8+ T‐cell responses, resulting in faster pathogen clearance and reduced liver pathology. Depletion experiments indicated that this effect was mediated by NK cells. Mechanistically, TRAIL expressed by immune cells positively and dose‐dependently modulates IL‐15 signaling‐induced granzyme B production in NK cells, leading to enhanced NK cell‐mediated T cell killing. TRAIL also regulates the signaling downstream of IL‐15 receptor in human NK cells. In addition, TRAIL restricts NK1.1‐triggered IFNγ production by NK cells. Our study reveals a hitherto unappreciated immunoregulatory role of TRAIL signaling on NK cells for the granzyme B‐dependent elimination of antiviral T cells.
  • Denise Barlow (1950-2017)-pioneer of genomic imprinting
    Item type: Other Journal Item
    Wutz, Anton (2017)
    EMBO Reports
  • Glucose uptake to guard cells via STP transporters provides carbon sources for stomatal opening and plant growth
    Item type: Journal Article
    Flütsch, Sabrina; Nigro, Arianna; Conci, Franco; et al. (2020)
    EMBO Reports
    Guard cells on the leaf epidermis regulate stomatal opening for gas exchange between plants and the atmosphere, allowing a balance between photosynthesis and transpiration. Given that guard cells possess several characteristics of sink tissues, their metabolic activities should largely depend on mesophyll-derived sugars. Early biochemical studies revealed sugar uptake into guard cells. However, the transporters that are involved and their relative contribution to guard cell function are not yet known. Here, we identified the monosaccharide/proton symporters Sugar Transport Protein 1 and 4 (STP1 and STP4) as the major plasma membrane hexose sugar transporters in the guard cells of Arabidopsis thaliana. We show that their combined action is required for glucose import to guard cells, providing carbon sources for starch accumulation and light-induced stomatal opening that are essential for plant growth. These findings highlight mesophyll-derived glucose as an important metabolite connecting stomatal movements with photosynthesis.
  • Innate, translation-dependent silencing of an invasive transposon in Arabidopsis
    Item type: Journal Article
    Oberlin, Stefan; Rajeswaran, Rajendran; Trasser, Marieke; et al. (2022)
    EMBO Reports
    Co-evolution between hosts' and parasites' genomes shapes diverse pathways of acquired immunity based on silencing small (s)RNAs. In plants, sRNAs cause heterochromatinization, sequence degeneration, and, ultimately, loss of autonomy of most transposable elements (TEs). Recognition of newly invasive plant TEs, by contrast, involves an innate antiviral-like silencing response. To investigate this response's activation, we studied the single-copy element EVADÉ (EVD), one of few representatives of the large Ty1/Copia family able to proliferate in Arabidopsis when epigenetically reactivated. In Ty1/Copia elements, a short subgenomic mRNA (shGAG) provides the necessary excess of structural GAG protein over the catalytic components encoded by the full-length genomic flGAG-POL. We show here that the predominant cytosolic distribution of shGAG strongly favors its translation over mostly nuclear flGAG-POL. During this process, an unusually intense ribosomal stalling event coincides with mRNA breakage yielding unconventional 5'OH RNA fragments that evade RNA quality control. The starting point of sRNA production by RNA-DEPENDENT-RNA-POLYMERASE-6 (RDR6), exclusively on shGAG, occurs precisely at this breakage point. This hitherto-unrecognized "translation-dependent silencing" (TdS) is independent of codon usage or GC content and is not observed on TE remnants populating the Arabidopsis genome, consistent with their poor association, if any, with polysomes. We propose that TdS forms a primal defense against EVD de novo invasions that underlies its associated sRNA pattern.
  • No single way to understand singlet oxygen signalling in plants
    Item type: Journal Article
    Kim, Chanhong; Meskauskiene, Rasa; Apel, Klaus; et al. (2008)
    EMBO Reports
  • HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia
    Item type: Journal Article
    Troilo, Albino; Alexander, Irina; Muehl, Sarah; et al. (2014)
    EMBO Reports
  • The role of scientific self‐regulation for the control of genome editing in the human germline
    Item type: Journal Article
    Gregorowius, Daniel; Biller-Andorno, Nikola; Deplazes‐Zemp, Anna (2017)
    EMBO Reports
Publications 1 - 10 of 21