Vaccine

Journal: Vaccine

Abbreviation

Vaccine

Publisher

Elsevier

ISSN

0264-410X
1358-8745

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Publications 1 - 10 of 20

Cholera toxin-B (ctxB) antigen expressing Salmonella Typhimurium polyvalent vaccine exerts protective immune response against Vibrio cholerae infection
Vishwakarma, Vikalp; Sahoo, Sushree S.; Das, Susmita; et al. (2015)
Vaccine
“EvoVax” – A rationally designed inactivated Salmonella Typhimurium vaccine induces strong and long-lasting immune responses in pigs
Lentsch, Verena; Aslani, Selma; Echtermann, Thomas; et al. (2023)
Vaccine
Salmonella enterica subspecies enterica serovar Typhimurium (S.Tm) poses a considerable threat to public health due to its zoonotic potential. Human infections are mostly foodborne, and pork and pork products are ranked among the top culprits for transmission. In addition, the high percentage of antibiotic resistance, especially in monophasic S.Tm, limits treatment options when needed. Better S.Tm control would therefore be of benefit both for farm animals and for safety of the human food chain. A promising pre-harvest intervention is vaccination. In this study we tested safety and immunogenicity of an oral inactivated S.Tm vaccine, which has been recently shown to generate an “evolutionary trap” and to massively reduce S.Tm colonization and transmission in mice. We show that this vaccine is highly immunogenic and safe in post-weaning pigs and that administration of a single oral dose results in a strong and long-lasting serum IgG response. This has several advantages over existing – mainly live – vaccines against S.Tm, both in improved seroconversion and reduced risk of vaccine-strain persistence and reversion to virulence.
PLGA-microencapsulation protects Salmonella typhi outer membrane proteins from acidic degradation and increases their mucosal immunogenicity
Carreño, Juan M.; Perez-Shibayama, Christian; Gil-Cruz, Cristina; et al. (2016)
Vaccine
Combined vaccination against IL-5 and eotaxin blocks eosinophilia in mice
Zou, Yu; Sonderegger, Ivo; Lipowsky, Gerd; et al. (2010)
Vaccine
TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses
Schlosser, Eva; Mueller, Marc; Fischer, Stefan; et al. (2008)
Vaccine
Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells
Waeckerle-Men, Ying; Allmen-Uetz, Edith von; Gander, Bruno A.; et al. (2006)
Vaccine
The impact of frost-damage on the quality and quantity of the secreted antigen-specific IgG repertoire
Rybczynska, Magda; Baudry, Jean; Eyer, Klaus (2020)
Vaccine
Freezing of alum-based vaccines drastically alters their colloidal composition and leads to irreversible cluster formation. The loss of stability is well described, but the impact of frost damage on the functionality of the induced and secreted antibody repertoire has not been studied in detail. We therefore applied our single-cell measurement platform to extract the frequencies of Immunoglobulin G-secreting cells in combination with individual secretion rates and affinities. We showed that, frost-damaged or not, the tested vaccine was able to generate similar frequencies of total and antigen-affine IgG-secreting cells. Additionally, the frost-damaged vaccine stimulated a similar T-cell cytokine secretion pattern when compared to the regularly stored vaccine. However, frost-damaged vaccines induced no efficient affinity maturation and a complete collapse of the affinity distribution was observed. This study unveiled the impact of frost-damage to alum-based vaccines on the induced secreted antibody repertoire, and illustrated the power of functional single-antibody analysis.
Immunogenicity of single-dose diphtheria vaccines based on PLA/PLGA microspheres in guinea pigs
Johansen, P.; Moon, L.; Tamber, H.; et al. (2000)
Vaccine
Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract
Fougeron, Delphine; Maelea, Laurye van; Songhet, Pascal; et al. (2015)
Vaccine
A self-administered virtual reality intervention increases COVID-19 vaccination intention
Mottelson, Aske; Vandeweerdt, Clara; Atchapero, Michael; et al. (2021)
Vaccine
Effective interventions for increasing people's intention to get vaccinated are crucial for global health, especially considering COVID-19. We devised a novel intervention using virtual reality (VR) consisting of a consultation with a general practitioner for communicating the benefits of COVID-19 vaccination and, in turn, increasing the intention to get vaccinated against COVID-19. We conducted a preregistered online experiment with a 2×2 between-participant design. People with eligible VR headsets were invited to install our experimental application and complete the ten minute virtual consultation study at their own discretion. Participants were randomly assigned across two age conditions (young or old self-body) and two communication conditions (with provision of personal benefit of vaccination only, or collective and personal benefit). The primary outcome was vaccination intention (score range 1–100) measured three times: immediately before and after the study, as well as one week later. Five-hundred-and-seven adults not vaccinated against COVID-19 were recruited. Among the 282 participants with imperfect vaccination intentions (<100), the VR intervention increased pre-to-post vaccination intentions across intervention conditions (mean difference 8.6, 95% CI 6.1 to 11.1,p<0.0001). The pre-to-post difference significantly correlated with the vaccination intention one week later, ρ=0.20,p<0.0001. The VR intervention was effective in increasing COVID-19 vaccination intentions both when only personal benefits and personal and collective benefits of vaccination were communicated, with significant retention one week after the intervention. Utilizing recent evidence from health psychology and embodiment research to develop immersive environments with customized and salient communication efforts could therefore be an effective tool to complement public health campaigns.

Publications 1 - 10 of 20

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