Journal: Cell Metabolism

Abbreviation

Cell Metab

Publisher

Elsevier

Journal Volumes

ISSN

1550-4131
1932-7420

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2018 - 201932020 - 20253
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Publications1 - 6 of 6
  • Piezo2 in sensory neurons regulates systemic and adipose tissue metabolism
    Item type: Journal Article
    Passini, Fabian S.; Bornstein, Bavat; Rubin, Sarah; et al. (2025)
    Cell Metabolism
    Systemic metabolism ensures energy homeostasis through inter-organ crosstalk regulating thermogenic adipose tissue. Unlike the well-described inductive role of the sympathetic system, the inhibitory signal ensuring energy preservation remains poorly understood. Here, we show that, via the mechanosensor Piezo2, sensory neurons regulate morphological and physiological properties of brown and beige fat and prevent systemic hypermetabolism. Targeting runt-related transcription factor 3 (Runx3)/parvalbumin (PV) sensory neurons in independent genetic mouse models resulted in a systemic metabolic phenotype characterized by reduced body fat and increased insulin sensitivity and glucose tolerance. Deletion of Piezo2 in PV sensory neurons reproduced the phenotype, protected against high-fat-diet-induced obesity, and caused adipose tissue browning and beiging, likely driven by elevated norepinephrine levels. Finding that brown and beige fat are innervated by Runx3/PV sensory neurons expressing Piezo2 suggests a model in which mechanical signals, sensed by Piezo2 in sensory neurons, protect energy storage and prevent a systemic hypermetabolic phenotype.
  • A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry
    Item type: Journal Article
    Damond, Nicolas; Engler, Stefanie; Zanotelli, Vito R.T.; et al. (2019)
    Cell Metabolism
  • Inhibition of mevalonate pathway prevents adipocyte browning in mice and men by affecting protein prenylation
    Item type: Journal Article
    Balaz, Miroslav; Becker, Anton S.; Balazova, Lucia; et al. (2019)
    Cell Metabolism
    Recent research focusing on brown adipose tissue (BAT) function emphasizes its importance in systemic metabolic homeostasis. We show here that genetic and pharmacological inhibition of the mevalonate pathway leads to reduced human and mouse brown adipocyte function in vitro and impaired adipose tissue browning in vivo. A retrospective analysis of a large patient cohort suggests an inverse correlation between statin use and active BAT in humans, while we show in a prospective clinical trial that fluvastatin reduces thermogenic gene expression in human BAT. We identify geranylgeranyl pyrophosphate as the key mevalonate pathway intermediate driving adipocyte browning in vitro and in vivo, whose effects are mediated by geranylgeranyltransferases (GGTases), enzymes catalyzing geranylgeranylation of small GTP-binding proteins, thereby regulating YAP1/TAZ signaling through F-actin modulation. Conversely, adipocyte-specific ablation of GGTase I leads to impaired adipocyte browning, reduced energy expenditure, and glucose intolerance under obesogenic conditions, highlighting the importance of this pathway in modulating brown adipocyte functionality and systemic metabolism.
  • Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice
    Item type: Journal Article
    Heine, Markus; Fischer, Alexander W.; Schlein, Christian; et al. (2018)
    Cell Metabolism
  • Total protein, not amino acid composition, differs in plant-based versus omnivorous dietary patterns and determines metabolic health effects in mice
    Item type: Journal Article
    MacArthur, Michael R.; Mitchell, Sarah J.; Treviño-Villarreal, J. Humberto; et al. (2021)
    Cell Metabolism
    Plant-based dietary patterns are associated with improved cardiometabolic health, but causal dietary components are unclear. Protein has been proposed to play a role, but the importance of protein quantity versus quality remains unknown. We investigated the contributions of total protein amount, amino acid (AA) composition, and plant versus animal source. Analysis of total protein and AA composition of food items and dietary patterns revealed differences between individual food items, but few differences between AA profiles of vegan versus omnivorous dietary patterns. Effects of protein quantity, but not quality, on cardiometabolic health markers were observed in mice using semi-purified diets with crystalline AAs in plant versus animal-based ratios and naturally sourced diets with whole-food ingredients. Our data show relatively little difference in protein quality between plant-based and omnivorous dietary patterns and that reduced total protein intake in plant-based dietary patterns may be a contributor to the benefits of plant-based diets. © 2021 Elsevier Inc.
  • James R. Mitchell (1971-2020)
    Item type: Other Journal Item
    Ristow, Michael; Lee, Chih-Hao; De Bock, Katrien; et al. (2021)
    Cell Metabolism
Publications1 - 6 of 6