Journal: Nature Reviews Cancer

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Nature

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1474-175X
1471-175X

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Publications 1 - 6 of 6
  • Tumour vascular targeting
    Item type: Journal Article
    Neri, Dario; Bicknell, Roy (2005)
    Nature Reviews Cancer
  • Multiplex protein imaging in tumour biology
    Item type: Review Article
    de Souza, Natalie; Zhao, Shan; Bodenmiller, Bernd (2024)
    Nature Reviews Cancer
    Tissue imaging has become much more colourful in the past decade. Advances in both experimental and analytical methods now make it possible to image protein markers in tissue samples in high multiplex. The ability to routinely image 40-50 markers simultaneously, at single-cell or subcellular resolution, has opened up new vistas in the study of tumour biology. Cellular phenotypes, interaction, communication and spatial organization have become amenable to molecular-level analysis, and application to patient cohorts has identified clinically relevant cellular and tissue features in several cancer types. Here, we review the use of multiplex protein imaging methods to study tumour biology, discuss ongoing attempts to combine these approaches with other forms of spatial omics, and highlight challenges in the field.
  • Otto Warburg's contributions to current concepts of cancer metabolism
    Item type: Other Journal Item
    Koppenol, Willem H.; Bounds, Patricia L.; Dang, Chi V. (2011)
    Nature Reviews Cancer
  • Biology, vulnerabilities and clinical applications of circulating tumour cells
    Item type: Review Article
    Ring, Alexander; Nguyen-Sträuli, Bich Doan; Wicki, Andreas; et al. (2023)
    Nature Reviews Cancer
    In recent years, exceptional technological advances have enabled the identification and interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading to new fields of research and fostering the promise for paradigm-changing, liquid biopsy-based clinical applications. Analysis of CTCs has revealed distinct biological phenotypes, including the presence of CTC clusters and the interaction between CTCs and immune or stromal cells, impacting metastasis formation and providing new insights into cancer vulnerabilities. Here we review the progress made in understanding biological features of CTCs and provide insight into exploiting these developments to design future clinical tools for improving the diagnosis and treatment of cancer.
  • Steering research on mRNA splicing in cancer towards clinical translation
    Item type: Journal Article
    Anczuków, Olga; Allain, Frédéric H.-T.; Angarola, Brittany L.; et al. (2024)
    Nature Reviews Cancer
    Splicing factors are affected by recurrent somatic mutations and copy number variations in several types of haematologic and solid malignancies, which is often seen as prima facie evidence that splicing aberrations can drive cancer initiation and progression. However, numerous spliceosome components also ‘moonlight’ in DNA repair and other cellular processes, making their precise role in cancer difficult to pinpoint. Still, few would deny that dysregulated mRNA splicing is a pervasive feature of most cancers. Correctly interpreting these molecular fingerprints can reveal novel tumour vulnerabilities and untapped therapeutic opportunities. Yet multiple technological challenges, lingering misconceptions, and outstanding questions hinder clinical translation. To start with, the general landscape of splicing aberrations in cancer is not well defined, due to limitations of short-read RNA sequencing not adept at resolving complete mRNA isoforms, as well as the shallow read depth inherent in long-read RNA-sequencing, especially at single-cell level. Although individual cancer-associated isoforms are known to contribute to cancer progression, widespread splicing alterations could be an equally important and, perhaps, more readily actionable feature of human cancers. This is to say that in addition to ‘repairing’ mis-spliced transcripts, possible therapeutic avenues include exacerbating splicing aberration with small-molecule spliceosome inhibitors, targeting recurrent splicing aberrations with synthetic lethal approaches, and training the immune system to recognize splicing-derived neoantigens.
  • Prostate carcinogenesis: inflammatory storms
    Item type: Review Article
    de Bono, Johann S.; Guo, Christina; Gurel, Bora; et al. (2020)
    Nature Reviews Cancer
    Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an altered microbiome being causally implicated. Intra-prostatic inflammatory cell recruitment and expansion can ultimately promote DNA double-strand breaks and androgen receptor activation in prostate epithelial cells. The activation of the senescence-associated secretory phenotype fuels further ‘inflammatory storms’, with free radicals leading to further DNA damage. This drives the overexpression of DNA repair and tumour suppressor genes, rendering these genes susceptible to mutagenic insults, with carcinogenesis accelerated by germline DNA repair gene defects. We provide updates on recent advances in elucidating prostate carcinogenesis and explore novel therapeutic and prevention strategies harnessing these discoveries. © 2020, Springer Nature Limited.
Publications 1 - 6 of 6