Toxicology in Vitro

Journal: Toxicology in Vitro

Abbreviation

Toxicol. in vitro

Publisher

Pergamon

ISSN

0887-2333

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Publications 1 - 7 of 7

The influence of modes of action and physicochemical properties of chemicals on the correlation between in vitro and acute fish toxicity data
Kramer, Nynke I.; Hermens, Joop L.M.; Schirmer, Kristin (2009)
Toxicology in Vitro
The humane collection of fetal bovine serum and possibilities for serum-free cell and tissue culture
Valka, J. van der; Mellor, D.; Brands, R.; et al. (2004)
Toxicology in Vitro
Gut microbial transformation of the dietary mutagen MeIQx may reduce exposure levels without altering intestinal transport
Zhang, Jianbo; Empl, Michael T.; Schneider, Mirjam; et al. (2019)
Toxicology in Vitro
The expression of PHOX2A, PHOX2B and of their target gene dopamine-β-hydroxylase (DβH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model
Benfante, Roberta; Antonini, Ruth Adele; Kuster, Niels; et al. (2008)
Toxicology in Vitro
The homeodomain transcription factors PHOX2A and PHOX2B are vital for development of the autonomic nervous system. Their spatial and temporal expression at the neural crest is instrumental in determining neuronal precursor fate, and by regulating DβH expression, the enzyme catalysing noradrenaline synthesis from dopamine, they also play a role in determination of noradrenergic phenotype. Disturbing this finely regulated process leads to disruption of autonomic development and autonomic dysfunction syndromes such as DβH deficiency. As it had previously been shown that the catecholamine system is responsive to ELF-EMF, and as this has also been linked to various pathologies and to certain types of cancer, we wondered whether exposure to this type of radiation could affect the expression of PHOX2A, PHOX2B and DβH, also during differentiation triggered by retinoic acid. To investigate this possibility we exposed the human SH-SY5Y neuroblastoma cell line to 50 Hz power-line magnetic field at various flux densities and for various exposure times. We measured gene expression in exposed cells compared to control cells and also investigated any changes at protein level. Using our exposure protocol, we found no changes at either transcript or protein level of these important components of the autonomic nervous system and catecholaminergic system.
Effects of clofibric acid alone and in combination with 17 beta-estradiol on mRNA abundance in primary hepatocytes isolated from rainbow trout
Sovadinova, I.; Liedtke, A.; Schirmer, K. (2014)
Toxicology in Vitro
Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B
Veljkovic, Emilija; Jiricny, Josef; Menigatti, Mirco; et al. (2011)
Toxicology in Vitro
Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry
Bovet, Cédric; Plet, Benoit; Ruff, Marc; et al. (2009)
Toxicology in Vitro

Publications 1 - 7 of 7

Journal: Toxicology in Vitro

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