Journal: Nature Reviews Microbiology

Abbreviation

Nat Rev Microbiol

Publisher

Nature

Journal Volumes

ISSN

1740-1526
1740-1534

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Publications 1 - 10 of 21
  • Scientists’ warning to humanity: microorganisms and climate change
    Item type: Review Article
    Cavicchioli, Ricardo; Ripple, William J.; Timmis, Kenneth N.; et al. (2019)
    Nature Reviews Microbiology
    In the Anthropocene, in which we now live, climate change is impacting most life on Earth. Microorganisms support the existence of all higher trophic life forms. To understand how humans and other life forms on Earth (including those we are yet to discover) can withstand anthropogenic climate change, it is vital to incorporate knowledge of the microbial ‘unseen majority’. We must learn not just how microorganisms affect climate change (including production and consumption of greenhouse gases) but also how they will be affected by climate change and other human activities. This Consensus Statement documents the central role and global importance of microorganisms in climate change biology. It also puts humanity on notice that the impact of climate change will depend heavily on responses of microorganisms, which are essential for achieving an environmentally sustainable future.
  • Biological control of soil-borne pathogens by fluorescent pseudomonads
    Item type: Journal Article
    Haas, Dieter; Défago, Geneviève (2005)
    Nature Reviews Microbiology
  • Evolutionary causes and consequences of bacterial antibiotic persistence
    Item type: Journal Article
    Bakkeren, Erik; Diard, Médéric; Hardt, Wolf-Dietrich (2020)
    Nature Reviews Microbiology
    Antibiotic treatment failure is of growing concern. Genetically encoded resistance is key in driving this process. However, there is increasing evidence that bacterial antibiotic persistence, a non-genetically encoded and reversible loss of antibiotic susceptibility, contributes to treatment failure and emergence of resistant strains as well. In this Review, we discuss the evolutionary forces that may drive the selection for antibiotic persistence. We review how some aspects of antibiotic persistence have been directly selected for whereas others result from indirect selection in disparate ecological contexts. We then discuss the consequences of antibiotic persistence on pathogen evolution. Persisters can facilitate the evolution of antibiotic resistance and virulence. Finally, we propose practical means to prevent persister formation and how this may help to slow down the evolution of virulence and resistance in pathogens.
  • The Social Network: deciphering fungal language
    Item type: Review Article
    Leeder, Abigail C.; Palma-Guerrero, Javier; Glass, N. Louise (2011)
    Nature Reviews Microbiology
    It has been estimated that up to one quarter of the world's biomass is of fungal origin, comprising approximately 1.5 million species. In order to interact with one another and respond to environmental cues, fungi communicate with their own chemical languages using a sophisticated series of extracellular signals and cellular responses. A new appreciation for the linkage between these chemical languages and developmental processes in fungi has renewed interest in these signalling molecules, which can now be studied using post-genomic resources. In this Review, we focus on the molecules that are secreted by the largest phylum of fungi, the Ascomycota, and the quest to understand their biological function.
  • Modification of intracellular membrane structures for virus replication
    Item type: Journal Article
    Miller, Sven; Krijnse-Locker, Jacomine (2008)
    Nature Reviews Microbiology
  • Targeting virulence: can we make evolution-proof drugs?
    Item type: Journal Article
    Allen, Richard C.; Popat, Roman; Diggle, Steve P.; et al. (2014)
    Nature Reviews Microbiology
  • The role of microbial motility and chemotaxis in symbiosis
    Item type: Review Article
    Raina, Jean-Baptiste; Fernandez, Vicente; Lambert, Bennett; et al. (2019)
    Nature Reviews Microbiology
  • Protein post-translational modifications in bacteria
    Item type: Review Article
    Macek, Boris; Forchhammer, Karl; Hardouin, Julie; et al. (2019)
    Nature Reviews Microbiology
  • Algal blooms in the ocean: hot spots for chemically mediated microbial interactions
    Item type: Review Article
    Kuhlisch, Constanze; Shemi, Adva; Barak-Gavish, Noa; et al. (2024)
    Nature Reviews Microbiology
    The cycling of major nutrients in the ocean is affected by large-scale phytoplankton blooms, which are hot spots of microbial life. Diverse microbial interactions regulate bloom dynamics. At the single-cell level, interactions between microorganisms are mediated by small molecules in the chemical crosstalk that determines the type of interaction, ranging from mutualism to pathogenicity. Algae interact with viruses, bacteria, parasites, grazers and other algae to modulate algal cell fate, and these interactions are dependent on the environmental context. Recent advances in mass spectrometry and single-cell technologies have led to the discovery of a growing number of infochemicals - metabolites that convey information - revealing the ability of algal cells to govern biotic interactions in the ocean. The diversity of infochemicals seems to account for the specificity in cellular response during microbial communication. Given the immense impact of algal blooms on biogeochemical cycles and climate regulation, a major challenge is to elucidate how microscale interactions control the fate of carbon and the recycling of major elements in the ocean. In this Review, we discuss microbial interactions and the role of infochemicals in algal blooms. We further explore factors that can impact microbial interactions and the available tools to decipher them in the natural environment.
  • Ecology, global diversity and evolutionary mechanisms in the Mycobacterium tuberculosis complex
    Item type: Review Article
    Goig, Galo A.; Windels, Etthel; Loiseau, Chloé; et al. (2025)
    Nature Reviews Microbiology
    With the COVID-19 pandemic receding, tuberculosis (TB) is again the number one cause of human death to a single infectious agent. TB is caused by bacteria that belong to the Mycobacterium tuberculosis complex (MTBC). Recent advances in genome sequencing have provided new insights into the ecology and evolution of the MTBC. This includes the discovery of new phylogenetic lineages within the MTBC, a deeper understanding of the host tropism among the various animal-adapted lineages, enhanced knowledge on the evolutionary dynamics of antimicrobial resistance and transmission, as well as a better grasp of the within-host MTBC diversity. Moreover, advances in long-read sequencing are increasingly highlighting the relevance of structural genomic variation in the MTBC. These findings not only shed new light on the biology and epidemiology of TB, but also give rise to new questions and research avenues. The purpose of this Review is to summarize these new insights and discuss their implications for global TB control.
Publications 1 - 10 of 21