Journal: LCGC North America

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Publisher

UBM Advanstar Communications

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ISSN

0888-9090

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20213
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Publications 1 - 3 of 3
  • Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part I: Basic Concepts
    Item type: Journal Article
    Stoll, Dwight R.; Broeckhoven, Ken (2021)
    LCGC North America
    Dispersion (the broadening or spreading) of analyte zones (peaks) outside of chromatography columns can seriously erode the resolution provided by good columns. Understanding the relationship between the level of dispersion associated with a given instrument relative to the intrinsic efficiency of a given column can help avoid disappointing results, especially when switching to new column technologies. In this installment, we focus on basic concepts in extracolumn dispersion as a prelude to future installments that will focus on dispersion in specific elements of HPLC systems.
  • Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part II: Sample Injection
    Item type: Journal Article
    Stoll, Dwight R.; Broeckhoven, Ken (2021)
    LCGC North America
    Dispersion (broadening, or spreading) of analyte zones (peaks) outside of chromatography columns can seriously erode the resolution provided by good columns. In this installment, we focus on the contribution of the sample injection step to the total level of extracolumn dispersion in a liquid chromatography (LC) system. This contribution has both a physical component (that is impacted by injector design and configuration and method variables) and a chemical component (that depends on the difference between the mobile phase and the sample solvent compositions).
  • Where has my efficiency gone? Impacts of extracolumn peak broadening on performance, part iii: Tubing and detectors
    Item type: Journal Article
    Stoll, Dwight R.; Broeckhoven, Ken (2021)
    LCGC North America
    Dispersion (broadening, or spreading) of analyte zones (peaks) outside of chromatography columns can seriously erode the resolution that good columns provide. In this installment, we focus on the contributions of dispersion in connecting tubing and detectors to the total level of extracolumn dispersion in a LC system.
Publications 1 - 3 of 3