Psychosomatic Medicine

Journal: Psychosomatic Medicine

Abbreviation

Psychosom Med

Publisher

Lippincott Williams & Wilkins

ISSN

0033-3174

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Publications 1 - 6 of 6

Coping processes and hemostatic reactivity to acute stress in dementia caregivers
Aschbacher, Kirstin; Patterson, Thomas L.; von Känel, Roland; et al. (2005)
Psychosomatic Medicine
Elevated Plasma C-Reactive Protein in Chronically Distressed Subjects Who Carry the A Allele of the TNF-α -308 G/A Polymorphism
Jeanmonod, Pascal; von Känel, Roland; Maly, Friedrich E.; et al. (2004)
Psychosomatic Medicine
An In Vitro Method to Investigate the Microbicidal Potential of Human Macrophages for Use in Psychosomatic Research
Kuebler, Ulrike; Ehlert, Ulrike; Zuccarella, Claudia; et al. (2013)
Psychosomatic Medicine
Reduced glucocorticoid sensitivity of monocyte interleukin-6 production in male industrial employees who are vitally exhausted
Wirtz, Petra H.; von Känel, Roland; Schnorpfeil, Pia; et al. (2003)
Psychosomatic Medicine
Objective: Proinflammatory changes are thought to link vital exhaustion with adverse cardiovascular outcomes. Monocytes play a central role in the pathogenesis of atherosclerotic lesions and are a major source of circulating cytokines. We hypothesized that vital exhaustion may alter the regulation of monocyte activity, as measured by lipopolysaccharide (LPS)-stimulated and glucocorticoid inhibited release of the proinflammatory cytokine interleukin-6 (IL-6). Methods: In 166 middle-aged apparently healthy men, vital exhaustion was measured by the Shortened Maastricht Exhaustion Questionnaire. Subjects in the highest quartile (highly exhausted, N = 38) were compared with those in the second and third quartiles (moderately exhausted N = 89) vs. those in the lowest quartile (nonexhausted, N = 39) in terms of plasma C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) levels, and as to IL-6 release after LPS stimulation in vitro. Inhibition of IL-6 release was determined by coincubation with increasing concentrations of dexamethasone. Monocyte glucocorticoid sensitivity was defined as the dexamethasone concentration inhibiting IL-6 release by 50%. Results: Highly exhausted individuals had higher CRP levels than nonexhausted subjects (p = .008). LPS-stimulated IL-6 release was not significantly different between groups. However, in highly exhausted participants, dexamethasone was less able to inhibit IL-6 release (p = .010), and the glucocorticoid sensitivity was lower (p = .003) than in nonexhausted subjects. Conclusions: In highly exhausted individuals, glucocorticoids exert less suppressive action on monocyte IL-6 release than in nonexhausted subjects. This finding points to altered regulation of monocyte cytokine production as one possible pathway linking exhaustion with atherosclerosis.
Exploring exposure to mobile phone electromagnetic fields and psychophysiological and self-rated symptoms response
Cinel, Caterina; Russo, Riccardo; Fox, Elaine; et al. (2009)
Psychosomatic Medicine
Neighborhoods and Health: Development and Validation of an Experimental Manipulation of Neighborhood Characteristics in a Virtual Environment
Hackman, Daniel A.; Robert, Stephanie A.; Grübel, Jascha; et al. (2017)
Psychosomatic Medicine

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