Journal: Neuroscience & Biobehavioral Reviews

Abbreviation

Neurosci. Biobehav. Rev.

Publisher

Elsevier

Journal Volumes

ISSN

0149-7634
1873-7528

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Publications 1 - 10 of 34
  • Epigenetics of childhood trauma: Long term sequelae and potential for treatment
    Item type: Journal Article
    Thumfart, Kristina M.; Jawaid, Ali; Bright, Kristina; et al. (2022)
    Neuroscience & Biobehavioral Reviews
    Childhood trauma (CT) can have persistent effects on the brain and is one of the major risk factors for neuropsychiatric diseases in adulthood. Recent advances in the field of epigenetics suggest that epigenetic factors such as DNA methylation and histone modifications, as well as regulatory processes involving non-coding RNA are associated with the long-term sequelae of CT. This narrative review summarizes current knowledge on the epigenetic basis of CT and describes studies in animal models and human subjects examining how the epigenome and transcriptome are modified by CT in the brain. It discusses psychological and pharmacological interventions that can counteract epigenetic changes induced by CT and the need to establish longitudinal assessment after CT for developing more effective diagnostics and treatment strategies based on epigenetic targets.
  • Familial Alzheimer's disease sustained by presenilin 2 mutations: Systematic review of literature and genotype–phenotype correlation
    Item type: Journal Article
    Canevelli, Marco; Piscopo, Paola; Talarico, Giuseppina; et al. (2014)
    Neuroscience & Biobehavioral Reviews
  • Proprioceptive sensibility in the elderly: degeneration, functional consequences and plastic-adaptive processes
    Item type: Journal Article
    Goble, D.J.; Coxon, J.P.; Wenderoth, N.; et al. (2009)
    Neuroscience & Biobehavioral Reviews
  • Substance related disorders are associated with impaired valuation of delayed gratification and feedback processing: A multilevel meta-analysis and meta-regression
    Item type: Review Article
    Kluwe-Schiavon, Bruno; Viola, T.W.; Sanvicente-Vieira, B.; et al. (2020)
    Neuroscience & Biobehavioral Reviews
  • In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders
    Item type: Review Article
    Meyer, Urs; Feldon, Joram; Fatemi, S. Hossein (2009)
    Neuroscience & Biobehavioral Reviews
  • Social Semantics: The role of conceptual knowledge and cognitive control in a neurobiological model of the social brain
    Item type: Journal Article
    Binney, Richard J.; Ramsey, Richard (2020)
    Neuroscience & Biobehavioral Reviews
    Research in social neuroscience has primarily focused on carving up cognition into distinct pieces, as a function of mental process, neural network or social behaviour, while the need for unifying models that span multiple social phenomena has been relatively neglected. Here we present a novel framework that treats social cognition as a case of semantic cognition, and which is neurobiologically constrained and generalizable, with clear, testable predictions regarding sociocognitive processing in the context of both health and disease. According to this framework, social cognition relies on two principal systems of representation and control. These systems are neuroanatomically and functionally distinct, but interact to (1) enable development of foundational, conceptual-level knowledge and (2) regulate access to this information in order to generate flexible and context-appropriate social behaviour. The Social Semantics framework shines new light on the mechanisms of social information processing by maintaining as much explanatory power as prior models of social cognition, whilst remaining simpler, by virtue of relying on fewer components that are “tuned” towards social interactions.
  • Predictive coding and dimension-selective attention enhance the lateralization of spoken language processing
    Item type: Review Article
    Preisig, Basil C.; Meyer, Martin (2025)
    Neuroscience & Biobehavioral Reviews
    Hemispheric lateralization in speech and language processing exemplifies functional brain specialization. Seminal work in patients with left hemisphere damage highlighted the left-hemispheric dominance in language functions. However, speech processing is not confined to the left hemisphere. Hence, some researchers associate lateralization with auditory processing asymmetries: slow temporal and fine spectral acoustic information is preferentially processed in right auditory regions, while faster temporal information is primarily handled by left auditory regions. Other scholars posit that lateralization relates more to linguistic processing, particularly for speech and speech-like stimuli. We argue that these seemingly distinct accounts are interdependent. Linguistic analysis of speech relies on top-down processes, such as predictive coding and dimension-selective auditory attention, which enhance lateralized processing by engaging left-lateralized sensorimotor networks. Our review highlights that lateralization is weaker for simple sounds, stronger for speech-like sounds, and strongest for meaningful speech. Evidence shows that predictive speech processing and selective attention enhance lateralization. We illustrate that these top-down processes rely on left-lateralized sensorimotor networks and provide insights into the role of these networks in speech processing.
  • Motor-cognitive intervention concepts can improve gait in chronic stroke, but their effect on cognitive functions is unclear: A systematic review with meta-analyses
    Item type: Journal Article
    Huber, Simone K.; Knols, Ruud H.; Arnet, Patrick; et al. (2022)
    Neuroscience & Biobehavioral Reviews
    Motor-cognitive intervention concepts are promising to counteract residual gait and cognitive impairments in chronic stroke. There is, however, considerable variation in motor-cognitive intervention types, which may lead to different effects. This systematic review strived to summarize and compare the effects of different motor-cognitive intervention concepts on gait and cognitive functions in chronic stroke. The systematic search identified twenty-nine articles, which were allocated to three types of motor-cognitive training concepts; SEQUENTIAL, SIMULTANEOUS-ADDITIONAL, and SIMULTANEOUS-INCORPORATED. Random-effects meta-analyses revealed that motor-cognitive interventions may be better than non-combined training approaches for improving gait function in chronic stroke (e.g. gait speed: g = 0.43, 95 % CI [0.22, 0.64], p < 0.0001). SIMULTANEOUS-INCORPORATED motor-cognitive training seems the most promising concept. As very few articles measured both, spatiotemporal gait parameters and cognitive outcomes, future studies are warranted to investigate the effects of motor-cognitive intervention concepts on gait control and cognitive functions in chronic stroke.
  • The midbrain periaqueductal gray as an integrative and interoceptive neural structure for breathing
    Item type: Review Article
    Faull, Olivia; Subramanian, Hari H.; Ezra, Martyn; et al. (2019)
    Neuroscience & Biobehavioral Reviews
  • Does chronic use of amphetamine-type stimulants impair interference control? – A meta-analysis
    Item type: Review Article
    Opitz, Antje; Petasch, Miriam-Sophie; Klappauf, Regine; et al. (2023)
    Neuroscience & Biobehavioral Reviews
    In substance use and addiction, inhibitory control is key to ignoring triggers, withstanding craving and maintaining abstinence. In amphetamine-type stimulant (ATS) users, most research focused on behavioral inhibition, but largely neglected the equally important subdomain of cognitive interference control. Given its crucial role in managing consumption, we investigated the relationship between interference control and chronic ATS use in adults. A database search (Pubmed & Web of Science) and relevant reviews were used to identify eligible studies. Effect sizes were estimated with random effects models. Subgroup, meta-regression, and sensitivity analyses explored heterogeneity in effect sizes. We identified 61 studies (53 datasets) assessing interference control in 1873 ATS users and 1905 controls. Findings revealed robust small effect sizes for ATS-related deficits in interference control, which were mainly seen in methamphetamine, as compared to MDMA users. The differential effects are likely due to tolerance-induced dopaminergic deficiencies (presumably most pronounced in methamphetamine users). Similarities between different ATS could be due to noradrenergic deficiencies; but elucidating their functional role in ATS users requires further/more research.
Publications 1 - 10 of 34