Journal: Clinical Neurophysiology

Abbreviation

Clin Neurophysiol

Publisher

Elsevier

Journal Volumes

ISSN

1388-2457
1872-8952

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Publications1 - 10 of 37
  • No increased sensitivity in brain function of children exposed to mobile phone-like emissions
    Item type: Journal Article
    Achermann, Peter; Loughran, Sarah P.; Benz, Dominik C.; et al. (2013)
    Clinical Neurophysiology
  • Plastic changes in the brain after a neuro-prosthetic leg use
    Item type: Other Journal Item
    Petrusic, Igor; Valle, Giacomo; Dakovic, Marko; et al. (2022)
    Clinical Neurophysiology
  • Stimulus probability affects the visual N700 component of the event-related potential
    Item type: Journal Article
    Althen, Heike; Banaschewski, Tobias J.; Brandeis, Daniel; et al. (2020)
    Clinical Neurophysiology
  • A technical guide to tDCS, and related non-invasive brain stimulation tools
    Item type: Journal Article
    Woods, Adam J.; Antal, A.; Bikson, Marom; et al. (2016)
    Clinical Neurophysiology
    Transcranial electrical stimulation (tES), including transcranial direct and alternating current stimulation (tDCS, tACS) are non-invasive brain stimulation techniques increasingly used for modulation of central nervous system excitability in humans. Here we address methodological issues required for tES application. This review covers technical aspects of tES, as well as applications like exploration of brain physiology, modelling approaches, tES in cognitive neurosciences, and interventional approaches. It aims to help the reader to appropriately design and conduct studies involving these brain stimulation techniques, understand limitations and avoid shortcomings, which might hamper the scientific rigor and potential applications in the clinical domain.
  • EEG variability in inflammatory encephalopathy: Dissemination in time and space
    Item type: Journal Article
    Binaghi , Enrico; Schwab , Nora; Capecchi , Francesco; et al. (2025)
    Clinical Neurophysiology
    Objective: To assess the diagnostic value of repeated EEG in differentiating autoimmune encephalitis (AE) from herpes simplex virus-associated viral encephalitis (HSVE). Methods: This observational case-control study analyzed 269 EEGs from 35 AE, 26 HSVE patients and two control groups with temporal lobe epilepsy (TLE) and acute non-inflammatory encephalopathy (ENC). We examined time- and space-related EEG changes in focal slowing (FS), epileptiform discharges (ED), and seizures. A five-item EEG variability score was calculated for each patient. Results: Patients with AE showed greater spatial variability in FS (46.4 % vs. 28.9 %, p < 0.001) and higher variability in FS severity (44.3 % vs. 34.6 %, p < 0.05) than patients with HSVE. Bilateral FS was more frequent in AE (67.7 % vs. 41.7 %, p = 0.05). AE demonstrated also higher ED location variability (37.5 % vs. 29.87 %, p = 0.058), and more bilateral ED (40 % vs. 23.5 %, p = 0.73). The EEG variability score was higher in patients with AE (2.34) than HSVE (1.43, p < 0.05) or in patients with TLE (1.17, p < 0.005) and acute encephalopathy (0.63, p < 0.001). Conclusion: AE is characterized by greater temporal and spatial EEG variability than HSVE. Significance: EEG variability is a consistent feature mainly seen in AE and may offer additional insights for differential diagnosis.
  • Different Cortical Activation in Writer's Cramp in Homozygote Twins During a Simple, Non Affected Motor Task
    Item type: Other Conference Item
    Benninger, David; Waldvogel, Daniel; Bassetti, Claudio; et al. (2008)
    Clinical Neurophysiology
  • Cortical involvement in the initiation of movementscued by moderate, but not loud acoustic stimuli: Evidence for subcortical mediation of the StartReact effect
    Item type: Journal Article
    Filli L.; Neumann, Lennart C.; Mahnoor, Nomah; et al. (2025)
    Clinical Neurophysiology
    Objective: The reticulospinal tract is critical for motor control, yet its role in human movement regulation remains incompletely understood. The StartReact effect is the primary method to assess reticulospinal motor control, although its neural mechanisms are debated. This study investigated the contribution of the motor cortex to the StartReact effect. Methods: The StartReact paradigm was administered to 22 healthy participants performing wrist extension movements to imperative stimuli (IS) consisting of either loud acoustic stimuli (LAS) or moderate acoustic stimuli (MAS). EMG and high-density EEG assessed muscle and cortical activity. Results: Reaction times were faster following LAS compared to MAS, reflecting the StartReact effect. Whereas movement-related cortical potentials emerged 21 ms before muscle activation following MAS, they appeared only 65 ms after muscle activation in LAS trials. Assessment of contingent negative variation (CNV) and event-related desynchronization (ERD) revealed no significant preparatory motor cortex activity prior to the IS. Conclusions: These findings suggest that while the motor cortex plays a crucial role in mediating MAS-induced movements, it is not critically involved in initiating accelerated movements induced by LAS. Significance: Our results suggest that the StartReact effect is a subcortical phenomenon that primarily assesses reticulospinal motor control.
  • High-density ECoG improves the detection of high frequency oscillations that predict seizure outcome
    Item type: Journal Article
    Boran, Ece; Ramantani, Georgia; Krayenbühl, Niklaus; et al. (2019)
    Clinical Neurophysiology
  • Is there a cluster of high theta-beta ratio patients in attention deficit hyperactivity disorder?
    Item type: Journal Article
    Bussalb, Aurore; Collin, Sidney; Barthélemy, Quentin; et al. (2019)
    Clinical Neurophysiology
  • Paired associative stimulation demonstrates alterations in motor cortical synaptic plasticity in patients with hepatic encephalopathy
    Item type: Journal Article
    Nikolov, Petyo; Baumgarten, Thomas J.; Hassan, Shady Safwat; et al. (2021)
    Clinical Neurophysiology
    Objective Hepatic encephalopathy (HE) is a potentially reversible brain dysfunction caused by liver failure. Altered synaptic plasticity is supposed to play a major role in the pathophysiology of HE. Here, we used paired associative stimulation with an inter-stimulus interval of 25 ms (PAS25), a transcranial magnetic stimulation (TMS) protocol, to test synaptic plasticity of the motor cortex in patients with manifest HE. Methods 23 HE-patients and 23 healthy controls were enrolled in the study. Motor evoked potential (MEP) amplitudes were assessed as measure for cortical excitability. Time courses of MEP amplitude changes after the PAS25 intervention were compared between both groups. Results MEP-amplitudes increased after PAS25 in the control group, indicating PAS25-induced synaptic plasticity in healthy controls, as expected. In contrast, MEP-amplitudes within the HE group did not change and were lower than in the control group, indicating no induction of plasticity. Conclusions Our study revealed reduced synaptic plasticity of the primary motor cortex in HE. Significance Reduced synaptic plasticity in HE provides a link between pathological changes on the molecular level and early clinical symptoms of the disease. This decrease may be caused by disturbances in the glutamatergic neurotransmission due to the known hyperammonemia in HE patients.
Publications1 - 10 of 37