Light: Science & Applications

Journal: Light: Science & Applications

Abbreviation

Light Sci Appl

Publisher

Nature

ISSN

2047-7538

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Publications 1 - 10 of 27

Bessel beam optical coherence microscopy enables multiscale assessment of cerebrovascular network morphology and function
Glandorf, Lukas Benjamin; Wittmann, Bastian; Droux, Jeanne; et al. (2024)
Light: Science & Applications
Understanding the morphology and function of large-scale cerebrovascular networks is crucial for studying brain health and disease. However, reconciling the demands for imaging on a broad scale with the precision of high-resolution volumetric microscopy has been a persistent challenge. In this study, we introduce Bessel beam optical coherence microscopy with an extended focus to capture the full cortical vascular hierarchy in mice over 1000 x 1000 x 360 mu m3 field-of-view at capillary level resolution. The post-processing pipeline leverages a supervised deep learning approach for precise 3D segmentation of high-resolution angiograms, hence permitting reliable examination of microvascular structures at multiple spatial scales. Coupled with high-sensitivity Doppler optical coherence tomography, our method enables the computation of both axial and transverse blood velocity components as well as vessel-specific blood flow direction, facilitating a detailed assessment of morpho-functional characteristics across all vessel dimensions. Through graph-based analysis, we deliver insights into vascular connectivity, all the way from individual capillaries to broader network interactions, a task traditionally challenging for in vivo studies. The new imaging and analysis framework extends the frontiers of research into cerebrovascular function and neurovascular pathologies.
Highly efficient THz four-wave mixing in doped silicon
Dessmann, Nils; Le, Nguyen H.; Eless, Viktoria; et al. (2021)
Light: Science & Applications
Third-order non-linearities are important because they allow control over light pulses in ubiquitous high-quality centro-symmetric materials like silicon and silica. Degenerate four-wave mixing provides a direct measure of the third-order non-linear sheet susceptibility χ(3)L (where L represents the material thickness) as well as technological possibilities such as optically gated detection and emission of photons. Using picosecond pulses from a free electron laser, we show that silicon doped with P or Bi has a value of χ(3)L in the THz domain that is higher than that reported for any other material in any wavelength band. The immediate implication of our results is the efficient generation of intense coherent THz light via upconversion (also a χ(3) process), and they open the door to exploitation of non-degenerate mixing and optical nonlinearities beyond the perturbative regime.
Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography
Basak, Kausik; Dean-Ben, Xose Luis; Gottschalk, Sven; et al. (2019)
Light: Science & Applications
Despite the importance of placental function in embryonic development, it remains poorly understood and challenging to characterize, primarily due to the lack of non-invasive imaging tools capable of monitoring placental and foetal oxygenation and perfusion parameters during pregnancy. We developed an optoacoustic tomography approach for real-time imaging through entire ~4 cm cross-sections of pregnant mice. Functional changes in both maternal and embryo regions were studied at different gestation days when subjected to an oxygen breathing challenge and perfusion with indocyanine green. Structural phenotyping of the cross-sectional scans highlighted different internal organs, whereas multi-wavelength acquisitions enabled non-invasive label-free spectroscopic assessment of blood-oxygenation parameters in foeto-placental regions, rendering a strong correlation with the amount of oxygen administered. Likewise, the placental function in protecting the embryo from extrinsically administered agents was substantiated. The proposed methodology may potentially further serve as a probing mechanism to appraise embryo development during pregnancy in the clinical setting.
Simple experimental procedures to distinguish photothermal from hot-carrier processes in plasmonics
Baffou, Guillaume; Bordacchini, Ivan; Baldi, Andrea; et al. (2020)
Light: Science & Applications
Light absorption and scattering of plasmonic metal nanoparticles can lead to non-equilibrium charge carriers, intense electromagnetic near-fields, and heat generation, with promising applications in a vast range of fields, from chemical and physical sensing to nanomedicine and photocatalysis for the sustainable production of fuels and chemicals. Disentangling the relative contribution of thermal and non-thermal contributions in plasmon-driven processes is, however, difficult. Nanoscale temperature measurements are technically challenging, and macroscale experiments are often characterized by collective heating effects, which tend to make the actual temperature increase unpredictable. This work is intended to help the reader experimentally detect and quantify photothermal effects in plasmon-driven chemical reactions, to discriminate their contribution from that due to photochemical processes and to cast a critical eye on the current literature. To this aim, we review, and in some cases propose, seven simple experimental procedures that do not require the use of complex or expensive thermal microscopy techniques. These proposed procedures are adaptable to a wide range of experiments and fields of research where photothermal effects need to be assessed, such as plasmonic-assisted chemistry, heterogeneous catalysis, photovoltaics, biosensing, and enhanced molecular spectroscopy.
Atomic scale memristive photon source
Cheng, Bojun; Zellweger, Till; Malchow, Konstantin; et al. (2022)
Light: Science & Applications
Memristive devices are an emerging new type of devices operating at the scale of a few or even single atoms. They are currently used as storage elements and are investigated for performing in-memory and neuromorphic computing. Amongst these devices, Ag/amorphous-SiOx/Pt memristors are among the most studied systems, with the electrically induced filament growth and dynamics being thoroughly investigated both theoretically and experimentally. In this paper, we report the observation of a novel feature in these devices: The appearance of new photoluminescent centers in SiOx upon memristive switching, and photon emission correlated with the conductance changes. This observation might pave the way towards an intrinsically memristive atomic scale light source with applications in neural networks, optical interconnects, and quantum communication.
Giant non-linear susceptibility of hydrogenic donors in silicon and germanium
Le, Nguyen H.; Lanskii, Grigory V.; Aeppli, Gabriel; et al. (2019)
Light: Science & Applications
Implicit summation is a technique for the conversion of sums over intermediate states in multiphoton absorption and the high-order susceptibility in hydrogen into simple integrals. Here, we derive the equivalent technique for hydrogenic impurities in multi-valley semiconductors. While the absorption has useful applications, it is primarily a loss process; conversely, the non-linear susceptibility is a crucial parameter for active photonic devices. For Si:P, we predict the hyperpolarizability ranges from χ(3)/n3D = 2.9 to 580 × 10−38 m5/V2 depending on the frequency, even while avoiding resonance. Using samples of a reasonable density, n3D, and thickness, L, to produce third-harmonic generation at 9 THz, a frequency that is difficult to produce with existing solid-state sources, we predict that χ(3) should exceed that of bulk InSb and χ(3)L should exceed that of graphene and resonantly enhanced quantum wells.
Femtojoule electro-optic modulation using a silicon–organic hybrid device
Köber, Sebastian; Palmer, Robert; Lauermann, Matthias; et al. (2015)
Light: Science & Applications
Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects, and silicon photonics is considered the leading technology for realizing such devices. However, the performance of all-silicon devices is limited by intrinsic material properties. In particular, the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging. Silicon–organic hybrid (SOH) integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials, thereby offering the prospect of designing optical properties by molecular engineering. In this paper, we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency: the 1-mm-long device consumes only 0.7 fJ bit−1 to generate a 12.5 Gbit s−1 data stream with a bit-error ratio below the threshold for hard-decision forward-error correction. This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system. It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation. The device features an electro-optic coefficient of r33≈180 pm V−1 and can be operated at data rates of up to 40 Gbit s−1.
Nonlinearity of optoacoustic signals and a new contrast mechanism for imaging
Malekzadeh-Najafabadi, Jaber; Prakash, Jaya; Razansky, Daniel; et al. (2025)
Light: Science & Applications
Optoacoustic signals behave nonlinearly at light fluences above a few mJ/cm2, which may affect the interpretation and quantification of measurements. It has been proposed that optoacoustic nonlinearity arises from the heat-induced formation of nanobubbles or changes in local thermo-physical parameters. However, such explanations are only valid at much higher fluences than typically used in biomedical optoacoustic imaging (> 20 mJ/cm2) or in the presence of materials with high absorption coefficients such as gold nanoparticles. We propose herein that electromagnetic permittivity changes in response to photon absorption are major source of optoacoustic signal nonlinearity at low fluences. We provide theoretical and experimental evidence that supports this postulation and show that optoacoustic pressure responses due to permittivity changes, which are function of thermally excited third-order nonlinear susceptibility, can explain the nonlinear behavior of the optoacoustic signal. Since different materials exhibit different thermally excited third-order nonlinear susceptibility, this property could function as a new contrast mechanism that can identify the sensitivity of a substance’s dielectric constant to photon-induced temperature changes. Consequently, we propose an imaging method based on nonlinear optoacoustic signals that exploits this newly identified contrast mechanism. These findings may have far-reaching implications for improving the accuracy of optoacoustics and utilizing the proposed new contrast mechanism would advance our understanding of cellular and tissue functionality.
Recent advances in ultrafast semiconductor disk lasers
Tilma, Bauke W.; Mangold, Mario; Zaugg, Christian A.; et al. (2015)
Light: Science & Applications
The performance of ultrafast semiconductor disk lasers has rapidly advanced in recent decades. The strong interest from industry for inexpensive, compact, and reliable ultrafast laser sources in the picosecond and femtosecond domains has driven this technology toward commercial products. Frequency metrology and biomedical applications would benefit from sub-200-femtosecond pulse durations with peak powers in the kilowatt range. The aim of this review is to briefly describe the market potential and give an overview of the current status of mode-locked semiconductor disk lasers. Particular focus is placed on the ongoing efforts to achieve shorter pulses with higher peak powers.
Subwavelength hybrid plasmonic structures for nonlinear nanophotonics
Michel, Ann-Katrin Ursula (2021)
Light: Science & Applications
Plasmonic structures made of a semiconductor-insulator-metal hybrid provide efficient routes for second-harmonic and sum-frequency generation in sub-micrometer structures, which ultimately may boost on-chip integrated plasmonic circuits.

Publications 1 - 10 of 27

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