Journal: Neuroradiology

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Springer

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2010 - 201942020 - 20221
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Publications1 - 5 of 5
  • Evaluation of 3D fat-navigator based retrospective motion correction in the clinical setting of patients with brain tumors
    Item type: Journal Article
    Glessgen, Carl; Gallichan, Daniel; Moor, Manuela; et al. (2019)
    Neuroradiology
  • Dependency of the blood oxygen level dependent-response to hyperoxic challenges on the order of gas administration in intracranial malignancies
    Item type: Journal Article
    Stieb, Sonja; Riesterer, Oliver; Boss, Andreas; et al. (2019)
    Neuroradiology
  • Single-subject analysis of regional brain volumetric measures can be strongly influenced by the method for head size adjustment
    Item type: Journal Article
    Opfer, Roland; Krüger, Julia; Spies, Lothar; et al. (2022)
    Neuroradiology
    Purpose Total intracranial volume (TIV) is often a nuisance covariate in MRI-based brain volumetry. This study compared two TIV adjustment methods with respect to their impact on z-scores in single subject analyses of regional brain volume estimates. Methods Brain parenchyma, hippocampus, thalamus, and TIV were segmented in a normal database comprising 5059 T1w images. Regional volume estimates were adjusted for TIV using the residual method or the proportion method. Age was taken into account by regression with both methods. TIV- and age-adjusted regional volumes were transformed to z-scores and then compared between the two adjustment methods. Their impact on the detection of thalamus atrophy was tested in 127 patients with multiple sclerosis. Results The residual method removed the association with TIV in all regions. The proportion method resulted in a switch of the direction without relevant change of the strength of the association. The reduction of physiological between-subject variability was larger with the residual method than with the proportion method. The difference between z-scores obtained with the residual method versus the proportion method was strongly correlated with TIV. It was larger than one z-score point in 5% of the subjects. The area under the ROC curve of the TIV- and age-adjusted thalamus volume for identification of multiple sclerosis patients was larger with the residual method than with the proportion method (0.84 versus 0.79). Conclusion The residual method should be preferred for TIV and age adjustments of T1w-MRI-based brain volume estimates in single subject analyses.
  • Impact of fMRI-guided advanced DTI fiber tracking techniques on their clinical applications in patients with brain tumors
    Item type: Journal Article
    Kleiser, Raimund; Staempfli, Philipp; Valavanis, Anton; et al. (2010)
    Neuroradiology
  • Mapping pathological changes in brain structure by combining T1- and T2-weighted MR imaging data
    Item type: Journal Article
    Ganzetti, Marco; Wenderoth, Nicole; Mantini, Dante (2015)
    Neuroradiology
    Introduction A workflow based on the ratio between standardized T1-weighted (T1-w) and T2-weighted (T2-w) MR images has been proposed as a new tool to study brain structure. This approach was previously used to map structural properties in the healthy brain. Here, we evaluate whether the T1-w/T2-w approach can support the assessment of structural impairments in the diseased brain. We use schizophrenia data to demonstrate the potential clinical utility of the technique. Methods We analyzed T1-w and T2-w images of 36 schizophrenic patients and 35 age-matched controls. These were collected for the Function Biomedical Informatics Research Network (fBIRN) collaborative project, which had an IRB approval and followed the HIPAA guidelines. We computed T1-w/T2-w images for each individual and compared intensities in schizophrenic and control groups on a voxel-wise basis, as well as in regions of interest (ROIs). Results Our results revealed that the T1-w/T2-w image permits to discriminate brain regions showing group-level differences between patients and controls with greater accuracy than conventional T1-w and T2-w images. Both the ROIs and the voxel-wise analysis showed globally reduced gray and white matter values in patients compared to controls. Significantly reduced values were found in regions such as insula, primary auditory cortex, hippocampus, inferior longitudinal fasciculus, and inferior fronto-occipital fasciculus. Conclusion Our findings were consistent with previous meta-analyses in schizophrenia corroborating the hypothesis of a potential “disconnection” syndrome in conjunction with structural alterations in local gray matter regions. Overall, our study suggested that the T1-w/T2-w technique permits to reliably map structural differences between the brains of patients and healthy individuals.
Publications1 - 5 of 5