Biotechnology and Bioengineering

Journal: Biotechnology and Bioengineering

Abbreviation

Biotechnol. Bioeng.

Publisher

Wiley

ISSN

0006-3592
1097-0290

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Publications 1 - 10 of 107

In silico genome-scale reconstruction and validation of the Staphylococcus aureus metabolic network
Heinemann, Matthias; Kümmel, Anne; Ruinatscha, Reto; et al. (2005)
Biotechnology and Bioengineering
Long-term continuous evolution of acetate resistant Acetobacter aceti
Steiner, Peter; Sauer, Uwe (2003)
Biotechnology and Bioengineering
Enhancing cell-based therapies with synthetic gene circuits responsive to molecular stimuli
Galvan, Silvia; Teixeira, Ana P.; Fussenegger, Martin (2024)
Biotechnology and Bioengineering
Synthetic biology aims to contribute to the development of next-generation patient-specific cell-based therapies for chronic diseases especially through the construction of sophisticated synthetic gene switches to enhance the safety and spatiotemporal controllability of engineered cells. Indeed, switches that sense and process specific cues, which may be either externally administered triggers or endogenous disease-associated molecules, have emerged as powerful tools for programming and fine-tuning therapeutic outputs. Living engineered cells, often referred to as designer cells, incorporating such switches are delivered to patients either as encapsulated cell implants or by infusion, as in the case of the clinically approved CAR-T cell therapies. Here, we review recent developments in synthetic gene switches responsive to molecular stimuli, spanning regulatory mechanisms acting at the transcriptional, translational, and posttranslational levels. We also discuss current challenges facing clinical translation of cell-based therapies employing these devices.
New-generation multicistronic expression platform
Fux, Cornelia; Langer, Dominik; Kelm, Jens M.; et al. (2004)
Biotechnology and Bioengineering
Online medium-throughput respirometry-based OTR measurements in magnetically stirred cultures
Brethauer, Simone; Held, Martin; Panke, Sven (2007)
Biotechnology and Bioengineering
High-throughput investigation of endothelial-to-mesenchymal transformation (EndMT) with combinatorial cellular microarrays
Wang, Zongjie; Calpe, Blaise; Zerdani, Jalil; et al. (2016)
Biotechnology and Bioengineering
Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP)
Müller-Späth, Thomas; Aumann, Lars; Melter, Lena; et al. (2008)
Biotechnology and Bioengineering
Analyzing characteristic length scales in biofilm structures
Milferstedt, K.; Pos, M.-N.; Morgenroth, E. (2009)
Biotechnology and Bioengineering
Exploiting Cell-Free Systems
Bujara, Matthias; Schümperli, Michael; Billerbeck, Sonja; et al. (2010)
Biotechnology and Bioengineering
Electrochemical optical waveguide lightmode spectroscopy (EC-OWLS)
Bearinger, J.P.; Vörös, Janos; Hubbell, J.A.; et al. (2003)
Biotechnology and Bioengineering

Publications 1 - 10 of 107

Journal: Biotechnology and Bioengineering

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