Alimentary Pharmacology and Therapeutics

Journal: Alimentary Pharmacology and Therapeutics

Abbreviation

Aliment. pharmacol. ther.

Publisher

Wiley-Blackwell

ISSN

1746-6334

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Publications 1 - 8 of 8

Editorial: the influence of genetic factors in mediating the effects of tobacco smoke in IBD—Authors’ reply
Lang, Brian M.; Beerenwinkel, Niko; Misselwitz, Benjamin (2018)
Alimentary Pharmacology and Therapeutics
Effects of baclofen on the functional anatomy of the oesophago-gastric junction and proximal stomach in healthy volunteers and patients with GERD assessed by magnetic resonance imaging and high-resolution manometry: a randomised controlled double-blind study
Curcic, Jelena; Schwizer, Alexandra; Kaufman, Elad; et al. (2014)
Alimentary Pharmacology and Therapeutics
Background The mechanism of reflux protection may involve a ‘flap valve’ at the oesophago-gastric junction (OGJ). Aim To assess the effects of baclofen, a gamma-aminobutyric acid receptor type-B (GABA-B) agonist known to suppress reflux events, on the ‘functional anatomy’ of the OGJ and proximal stomach after a large test meal. Methods Twelve healthy volunteers (HVs) and 12 patients with gastro-oesophageal reflux disease (GERD); with erosive oesophagitis or pathological oesophageal acid exposure completed a randomised, double-blind, cross-over study. On 2 test days participants received 40-mg baclofen or placebo before ingestion of a large test meal. OGJ structure and function were assessed by high-resolution manometry (HRM) and magnetic resonance imaging (MRI) using validated methods. Measurements of the oesophago-gastric angle were derived from three-dimensional models reconstructed from anatomic MRI images. Cine-MRI and HRM identified postprandial reflux events. Mixed model analysis and Wilcoxon rank signed tests assessed differences between participant groups and treatment conditions. Results In both HVs and GERD patients, baclofen reduced the frequency of postprandial reflux events. The oesophago-gastric insertion angle in GERD patients was reduced (−4.1 ± 1.8, P = 0.025), but was unchanged in healthy controls. In both study groups, baclofen augmented lower oesophageal sphincter (LES) pressure (HVs: +7.3 ± 1.8 mmHg, P < 0.0001, GERD: +4.50 ± 1.49 mmHg, P < 0.003) and increased LES length (HVs: +0.48 ± 0.11 cm, P < 0.0003, GERD: +0.35 ± 0.06 cm, P < 0.0001). Conclusions Baclofen inhibits transient LES relaxations and augments LES pressure and length. Additionally, baclofen has effects on the ‘functional anatomy’ of the OGJ and proximal stomach in GERD patients, which may suppress reflux by means of a ‘flap valve’ mechanism.
Analysis of the meal-dependent intragastric perfromance of a gastric-retentive tablet assessed by magnetic resonance imaging
Steingoetter, A.; Kunz, P.; Weishaupt, D.; et al. (2003)
Alimentary Pharmacology and Therapeutics
Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease
Lang, Brian M.; Biedermann, Luc; Van Haaften, Wouter; et al. (2018)
Alimentary Pharmacology and Therapeutics
Baclofen and transient lower oesophageal sphincter relaxations - the band plays on - authors' reply
Fox, M.; Curcic, J. (2014)
Alimentary Pharmacology and Therapeutics
Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome
Chassard, C.; Dapoigny, M.; Scott, K. P.; et al. (2012)
Alimentary Pharmacology and Therapeutics
Effects of meal consistency and ingested fluid volume on the intragastric distribution of a drug model in humans
Faas, H.; Steingoetter, A.; Feinle, C.; et al. (2002)
Alimentary Pharmacology and Therapeutics
Analysis of the meal-dependent intragastric performance of a gastric-retentive tablet assessed by magnetic resonance imaging
Steingoetter, A.; Kunz, P.; Weishaupt, D.; et al. (2003)
Alimentary Pharmacology and Therapeutics

Publications 1 - 8 of 8

Journal: Alimentary Pharmacology and Therapeutics

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