ACS Biomaterials Science & Engineering

Journal: ACS Biomaterials Science & Engineering

Abbreviation

ACS Biomater. Sci. Eng.

Publisher

American Chemical Society

ISSN

2373-9878

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Publications 1 - 10 of 19

Macrophage Polarization by Titanium Dioxide (TiO2) Particles: Size Matters
Schoenenberger, Angelina D.; Schipanski, Angela; Malheiro, Vera; et al. (2016)
ACS Biomaterials Science & Engineering
Nanomechanics on FGF-2 and Heparin Reveal Slip Bond Characteristics with pH Dependency
Sevim, Semih; Ozer, Sevil; Jones, Gabriel; et al. (2017)
ACS Biomaterials Science & Engineering
Mixed Metal Oxide Nanoparticle Formulations for the Treatment of Seroma
Lese, Ioana; Tsai, Catherine; Matter, Martin T.; et al. (2021)
ACS Biomaterials Science & Engineering
Seroma formation is a well-recognized postoperative complication for many plastic and general surgical procedures. Although various tissue adhesives and substances have been used in an effort to treat seroma formation, no therapies have been established clinically. Recently, the nano-bridging phenomenon has been introduced as a promising approach to achieve tissue adhesion and strong closure of deep skin wounds in rats. The present study seeks to assess the potential of nano-bridging beyond skin wounds in a rat model of seroma. Seromas were induced in 20 Lewis rats through bilateral axillary lymphadenectomy, excision of the latissimus dorsi and cutaneous maximus muscles, and disruption of dermal lymphatics. On postoperative day (POD) 7, the seroma was aspirated on both sides. A bioactive nanoparticle (NP) suspension based on zinc-doped strontium-substituted bioglass/ceria nanoparticles (NP group) or fibrin glue (fibrin group) was injected into the right seroma cavity, while the left side was left untreated. On POD 14, the NP group showed complete remission (no seromas at all), while the fibrin group recorded a reduction of only 63% in the seroma fluid volume. The NPs exerted local anti-inflammatory and neo-angiogenic effects, without any detectable systemic changes. Moreover, the ceria levels recorded in the organs did not surpass the background level, indicating that the nanoparticles stayed at the site of application. This study is a promising first example demonstrating the ability of inorganic nanoparticle formulations to reduce seroma formation in a rat model, without any detectable systemic adverse effects. These results emphasize the potential of nanotechnological solutions in the therapeutic management of seroma in the clinical setting.
Factor XIII Cross-Linked Hyaluronan Hydrogels for Cartilage Tissue Engineering
Broguiere, Nicolas; Cavalli, Emma; Salzmann, Gian M.; et al. (2016)
ACS Biomaterials Science & Engineering
Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk-Collagen Hydrogels
Khoo, Amanda S.; Valentin, Thomas M.; Leggett, Susan E.; et al. (2019)
ACS Biomaterials Science & Engineering
Special Biodegradable Fixation Device for Anterior Cruciate Ligament Reconstruction–Safety and Efficacy in a Beagle Model
Mao, Gen-Wen; Gong, Hai-Bo; Wang, Ying; et al. (2018)
ACS Biomaterials Science & Engineering
Synthesis of pH-sensitive Biocompatible PEG Hydrogels by Potassium Acyltrifluoroborate (KAT) Amide Ligation
Mazunin, Dmitry; Broguiere, Nicolas; Zenobi-Wong, Marcy; et al. (2015)
ACS Biomaterials Science & Engineering
Characterizing the Effects of Synergistic Thermal and Photo-Cross-Linking during Biofabrication on the Structural and Functional Properties of Gelatin Methacryloyl (GeIMA) Hydrogels
Chansoria, Parth; Asif, Suleman; Polkoff, Kathryn; et al. (2021)
ACS Biomaterials Science & Engineering
Gelatin methacryloyl (GelMA) hydrogels have emerged as promising and versatile biomaterial matrices with applications spanning drug delivery, disease modeling, and tissue engineering and regenerative medicine. GelMA exhibits reversible thermal cross-linking at temperatures below 37 degrees C due to the entanglement of constitutive polymeric chains, and subsequent ultraviolet (UV) photo-cross-linking can covalently bind neighboring chains to create irreversibly cross-linked hydrogels. However, how these cross-linking modalities interact and can be modulated during biofabrication to control the structural and functional characteristics of this versatile biomaterial is not well explored yet. Accordingly, this work characterizes the effects of synergistic thermal and photo-cross-linking as a function of GelMA solution temperature and UV photo-cross-linking duration during biofabrication on the hydrogels' stiffness, microstructure, proteolytic degradation, and responses of NIH 3T3 and human adipose-derived stem cells (hASC). Smaller pore size, lower degradation rate, and increased stiffness are reported in hydrogels processed at lower temperature or prolonged UV exposure. In hydrogels with low stiffness, the cells were found to shear the matrix and cluster into microspheroids, while poor cell attachment was noted in high stiffness hydrogels. In hydrogels with moderate stiffness, ones processed at lower temperature demonstrated better shape fidelity and cell proliferation over time. Analysis of gene expression of hASC encapsulated within the hydrogels showed that, while the GelMA matrix assisted in maintenance of stem cell phenotype (CD44), a higher matrix stiffness resulted in higher pro-inflammatory marker (ICAM1) and markers for cell-matrix interaction (ITGA1 and ITGA10). Analysis of constructs with ultrasonically patterned hASC showed that hydrogels processed at higher temperature possessed lower structural fidelity but resulted in more cell elongation and greater anisotropy over time. These findings demonstrate the significant impact of GelMA material formulation and processing conditions on the structural and functional properties of the hydrogels. The understanding of these material-process-structure-function interactions is critical toward optimizing the functional properties of GelMA hydrogels for different targeted applications.
Macroporous Aligned Hydrogel Microstrands for 3D Cell Guidance
Rizzo, Riccardo; Bonato, Angela; Chansoria, Parth; et al. (2022)
ACS Biomaterials Science & Engineering
Tissue engineering strongly relies on the use of hydrogels as highly hydrated 3D matrices to support the maturation of laden cells. However, because of the lack of microarchitecture and sufficient porosity, common hydrogel systems do not provide physical cell-instructive guidance cues and efficient transport of nutrients and oxygen to the inner part of the construct. A controlled, organized cellular alignment and resulting alignment of secreted ECM are hallmarks of muscle, tendons, and nerves and play an important role in determining their functional properties. Although several strategies to induce cellular alignment have been investigated in 2D systems, the generation of cell-instructive 3D hydrogels remains a challenge. Here, we report on the development of a simple and scalable method to efficiently generate highly macroporous constructs featuring aligned guidance cues. A precross-linked bulk hydrogel is pressed through a grid with variable opening sizes, thus deconstructing it into an array of aligned, high aspect ratio microgels (microstrands) with tunable diameter that are eventually stabilized by a second photoclick cross-linking step. This method has been investigated and optimized both in silico and in vitro, thereby leading to conditions with excellent viability and organized cellular alignment. Finally, as proof of concept, the method has been shown to direct aligned muscle tissue maturation. These findings demonstrate the 3D physical guidance potential of our system, which can be used for a variety of anisotropic tissues and applications.
Fiber-Enforced Hydrogels: Hagfish Slime Stabilized with Biopolymers including κ-Carrageenan
Böcker, Lukas; Rühs, Patrick A.; Böni, Lukas; et al. (2016)
ACS Biomaterials Science & Engineering

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