Journal: Bone

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Elsevier

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ISSN

8756-3282

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Publications 1 - 10 of 122
  • Tissue modulus calculated from beam theory is biased by bone size and geometry
    Item type: Journal Article
    van Lenthe, G. Harry; Voide, Romain; Boyd, Steven K.; et al. (2008)
    Bone
  • Volumetric spatial decomposition of trabecular bone into rods and plates
    Item type: Journal Article
    Stauber, Martin; Müller, Ralph (2006)
    Bone
  • A multi-stack registration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans
    Item type: Journal Article
    Whittier, Danielle E.; Walle, Matthias; Schenk, Denis; et al. (2023)
    Bone
    Background: Recent applications of high-resolution peripheral quantitative computed tomography (HR-pQCT) have demonstrated that changes in local bone remodelling can be quantified in vivo using longitudinal three-dimensional image registration. However, certain emerging applications, such as fracture healing and joint analysis, require larger multi-stack scan regions that can result in stack shift image artifacts. These artifacts can be detrimental to the accurate alignment of the bone structure across multiple timepoints. The purpose of this study was to establish a multi-stack registration protocol for evaluating longitudinal HR-pQCT images and to assess the accuracy and precision error in comparison with measures obtained using previously established three-dimensional longitudinal registration. Methods: Three same day multi-stack HR-pQCT scans of the radius (2 stacks in length) and tibia (3 stacks in length) were obtained from 39 healthy individuals who participated in a previous reproducibility study. A fully automated multi-stack registration algorithm was developed to re-align stacks within a scan by leveraging slight offsets between longitudinal scans. Stack shift severity before and after registration was quantified using a newly proposed stack-shift severity score. The false discovery rate for bone remodelling events and precision error of bone morphology and micro-finite element analysis parameters were compared between longitudinally registered scans with and without the addition of multi-stack registration. Results: Most scans (82 %) improved in stack alignment or maintained the lowest stack shift severity score when multi-stack registration was implemented. The false discovery rate of bone remodelling events significantly decreased after multi-stack registration, resulting in median false detection of bone formation and resorption fractions between 3.2 to 7.5 % at the radius and 3.4 to 5.3 % at the tibia. Further, precision error was significantly reduced or remained unchanged in all standard bone morphology and micro-finite element analysis parameters, except for total and trabecular cross-sectional areas. Conclusion: Multi-stack registration is an effective strategy for accurately aligning multi-stack HR-pQCT scans without modification of the image acquisition protocol. The algorithm presented here is a viable approach for performing accurate morphological analysis on multi-stack HR-pQCT scans, particularly for advanced application investigating local bone remodelling in vivo.
  • Morphometric analysis of human bone biopsies
    Item type: Journal Article
    Müller, Ralph; Van Campenhout, H.; Van Damme, B.; et al. (1998)
    Bone
  • Enhanced trabecular bone mass and architecture in transgenic mice constitutively overexpressing histone H4 derived osteogenic growth peptide
    Item type: Other Conference Item
    Smith, E.; Meyerose, T.; Kohler, T.; et al. (2003)
    Bone
  • Abnormal morphological features of osteocyte lacunae in adolescent idiopathic scoliosis: A large-scale assessment by ultra-high-resolution micro-computed tomography
    Item type: Journal Article
    Yang, Kenneth Guangpu; Goff, Elliott; Cheng, Ka-lo; et al. (2023)
    Bone
    Aim: Abnormal osteocyte lacunar morphology in adolescent idiopathic scoliosis (AIS) has been reported while the results were limited by the number of osteocyte lacunae being quantified. The present study aimed to validate previous findings through (a) comparing morphological features of osteocyte lacunae between AIS patients and controls in spine and ilium using a large-scale assessment, and (b) investigating whether there is an association between the acquired morphological features of osteocyte lacunae and disease severity in AIS. Method: Trabecular bone tissue of the facet joint of human vertebrae on both concave and convex sides at the apex of the scoliotic curve were collected from 4 AIS and 5 congenital scoliosis (CS) patients, and also at the same anatomic site from 3 non-scoliosis (NS) subjects intraoperatively. Trabecular bone tissue from ilium was obtained from 12 AIS vs 9 NS subjects during surgery. Osteocyte lacunae were assessed using ultra-high-resolution micro-computed tomography. Clinical information such as age, body mass index (BMI) and radiological Cobb angle of the major curve were collected. Results: There was no significant difference between density of osteocyte lacuna and bone volume fraction (BV/TV) between groups. A total of 230,076 and 78,758 osteocyte lacunae from facet joints of apical vertebra of scoliotic curve and iliac bone were included in the analysis, respectively. In facet joint bone biopsies, lacunar stretch (Lc.St) was higher, and lacunar equancy (Lc.Eq), lacunar oblateness (Lc.Ob), and lacunar sphericity (Lc.Sr) were lower in AIS and CS groups when compared with NS group. CA side was associated with higher Lc.St when compared with CX side. In iliac bone biopsies, Lc.Ob was higher and lacunar surface area (Lc.S) was lower in AIS group than NS group. Median values of Lc.St, Lc.Eq and Lc.Sr were significantly associated with radiological Cobb angle with adjustment for age and BMI (R-squared: 0.576, 0.558 and 0.543, respectively). Conclusions: This large-scale assessment of osteocyte lacunae confirms that AIS osteocyte lacunae are more oblate in iliac bone that is less influenced by asymmetric loading of the deformed spine than the vertebrae. Shape of osteocyte lacunae in iliac bone is associated with radiological Cobb angle of the major curve in AIS patients, suggesting the likelihood of systemic abnormal osteocyte morphology in AIS. Osteocyte lacunae from concave side of scoliotic curves were more stretched in both AIS and CS groups, which is likely secondary to asymmetric mechanical loading.
  • Advanced imaging surrogates of bone strength
    Item type: Other Conference Item
    Müller, Ralph (2007)
    Bone
  • Mineralization kinetics in murine trabecular bone quantified by time-lapsed in vivo micro-computed tomography
    Item type: Journal Article
    Lukas, C.; Ruffoni, D.; Lambers, F. M.; et al. (2013)
    Bone
  • The muscle-bone interaction in Turner syndrome
    Item type: Journal Article
    Soucek, Ondrej; Matyskova, Jana; Anliker, Elmar; et al. (2015)
    Bone
  • Anatomical and functional CT imaging of bone
    Item type: Other Conference Item
    Müller, Ralph (2005)
    Bone
Publications 1 - 10 of 122