American Journal of Physiology. Endocrinology and Metabolism

Journal: American Journal of Physiology. Endocrinology and Metabolism

Abbreviation

Am J Physiol Endocrinol Metab

Publisher

American Physiological Society

ISSN

0193-1849
1522-1555

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Publications 1 - 10 of 14

Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences
David, Valentin; Lafage-Proust, Marie-Hélène; Laroche, Norbert; et al. (2006)
American Journal of Physiology. Endocrinology and Metabolism
Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine
Boehm, Ernest; Chan, Sharon; Monfared, Mina; et al. (2003)
American Journal of Physiology. Endocrinology and Metabolism
Role of creatine and creatine kinase in UCP1-independent adipocyte thermogenesis
Wallimann, Theo; Tokarska-Schlattner, Malgorzata; Kay, Laurence; et al. (2020)
American Journal of Physiology. Endocrinology and Metabolism
Relation of diet-induced thermogenesis to brown adipose tissue activity in healthy men
Loeliger, Rahel C.; Maushart, Claudia I.; Gashi, Gani; et al. (2021)
American Journal of Physiology. Endocrinology and Metabolism
Human brown adipose tissue (BAT) is a thermogenic tissue activated by the sympathetic nervous system in response to cold exposure. It contributes to energy expenditure (EE) and takes up glucose and lipids from the circulation. Studies in rodents suggest that BAT contributes to the transient rise in EE after food intake, so-called diet-induced thermogenesis (DIT). We investigated the relationship between human BAT activity and DIT in response to glucose intake in 17 healthy volunteers. We assessed DIT, cold-induced thermogenesis (CIT), and maximum BAT activity at three separate study visits within 2 wk. DIT was measured by indirect calorimetry during an oral glucose tolerance test. CIT was assessed as the difference in EE after cold exposure of 2-h duration as compared with warm conditions. Maximal activity of BAT was assessed by 18-F-fluoro-deoxyglucose (18F-FDG) 18F-FDG-PET/MRI after cold exposure and concomitant pharmacological stimulation with mirabegron. Seventeen healthy men (mean age = 23.4 yr, mean body mass index = 23.2 kg/m2) participated in the study. EE increased from 1,908 (±181) kcal/24 h to 2,128 (±277) kcal/24 h (P < 0.0001, +11.5%) after mild cold exposure. An oral glucose load increased EE from 1,911 (±165) kcal/24 h to 2,096 (±167) kcal/24 h at 60 min (P < 0.0001, +9.7%). The increase in EE in response to cold was significantly associated with BAT activity (R2 = 0.43, P = 0.004). However, DIT was not associated with BAT activity (R2 = 0.015, P = 0.64). DIT after an oral glucose load was not associated with stimulated 18F-FDG uptake into BAT, suggesting that DIT is independent from BAT activity in humans (Clinicaltrials.gov Registration No. NCT03189511).NEW & NOTEWORTHY Cold-induced thermogenesis (CIT) was related to BAT activity as determined by FDG-PET/MRI after stimulation of BAT. Diet-induced thermogenesis (DIT) was not related to stimulated BAT activity. Supraclavicular skin temperature was related to CIT but not to DIT. DIT in humans is probably not a function of BAT.
Cafeteria diet-induced insulin resistance is not associated with decreased insulin signaling or AMPK activity and is alleviated by physical training in rats
Brandt, Nina; De Bock, Katrien; Richter, Erik A.; et al. (2010)
American Journal of Physiology. Endocrinology and Metabolism
A mathematical model for the mating-induced prolactin rhythm of female rats
Bertram, Richard; Egli, Marcel; Toporikova, Natalia; et al. (2006)
American Journal of Physiology. Endocrinology and Metabolism
Evaluation of intramyocellular lipid breakdown during exercise by biochemical assay, NMR spectroscopy, and Oil Red O staining
De Bock, Katrien; Dresselaers, Tom; Kiens, Bente; et al. (2007)
American Journal of Physiology. Endocrinology and Metabolism
Electrolysis stimulates creatine transport and transporter cell surface expression in incubated mouse skeletal muscle: potential role of ROS
Derave, Wim; Straumann, Nadine; Olek, Robert A.; et al. (2006)
American Journal of Physiology. Endocrinology and Metabolism
TRPC1 regulates brown adipose tissue activity in a PPARγ-dependent manner
Wolfrum, Christian; Kiehlmann, Elke; Pelczar, Pawel (2018)
American Journal of Physiology. Endocrinology and Metabolism
Inconsistencies in the assessment of food intake
Woods, Stephen C.; Langhans, Wolfgang (2012)
American Journal of Physiology. Endocrinology and Metabolism

Publications 1 - 10 of 14

Journal: American Journal of Physiology. Endocrinology and Metabolism

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