Journal: Seminars in Immunopathology

Abbreviation

Semin. Immunopathol.

Publisher

Springer

Journal Volumes

ISSN

1863-2297
1863-2300

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Publications 1 - 6 of 6
  • Narcolepsy: a model interaction between immune system, nervous system, and sleep-wake regulation
    Item type: Review Article
    Latorre, Daniela; Sallusto, Federica; Bassetti, Claudio L.A.; et al. (2022)
    Seminars in Immunopathology
    Narcolepsy is a rare chronic neurological disorder characterized by an irresistible excessive daytime sleepiness and cataplexy. The disease is considered to be the result of the selective disruption of neuronal cells in the lateral hypothalamus expressing the neuropeptide hypocretin, which controls the sleep-wake cycle. Diagnosis and management of narcolepsy represent still a substantial medical challenge due to the large heterogeneity in the clinical manifestation of the disease as well as to the lack of understanding of the underlying pathophysiological mechanisms. However, significant advances have been made in the last years, thus opening new perspective in the field. This review describes the current knowledge of clinical presentation and pathology of narcolepsy as well as the existing diagnostic criteria and therapeutic intervention for the disease management. Recent evidence on the potential immune-mediated mechanisms that may underpin the disease establishment and progression are also highlighted.
  • Taking the lymphatic route: dendritic cell migration to draining lymph nodes
    Item type: Journal Article
    Teijeira, Alvaro; Russo, Erica; Halin, Cornelia (2014)
    Seminars in Immunopathology
    In contrast to leukocyte migration through blood vessels, trafficking via lymphatic vessels (LVs) is much less well characterized. An important cell type migrating via this route is antigen-presenting dendritic cells (DCs), which are key for the induction of protective immunity as well as for the maintenance of immunological tolerance. In this review, we will summarize and discuss current knowledge of the cellular and molecular events that control DC migration from the skin towards, into, and within LVs, followed by DC arrival and migration in draining lymph nodes. Finally, we will discuss potential strategies to therapeutically target this migratory step to modulate immune responses.
  • Hemostasis, endothelial stress, inflammation, and the metabolic syndrome
    Item type: Journal Article
    Grandl, Gerald; Wolfrum, Christian (2018)
    Seminars in Immunopathology
    Obesity and the metabolic syndrome (MS) are two of the pressing healthcare problems of our time. The MS is defined as increased abdominal obesity in concert with elevated fasting glucose levels, insulin resistance, elevated blood pressure, and plasma lipids. It is a key risk factor for type 2 diabetes mellitus (T2DM) and for cardiovascular complications and mortality. Here, we review work demonstrating that various aspects of coagulation and hemostasis, as well as vascular reactivity and function, become impaired progressively during chronic ingestion of a western diet, but also acutely after meals. We outline that both T2DM and cardiovascular disease should be viewed as inflammatory diseases and describe that chronic overload of free fatty acids and glucose can trigger inflammatory pathways directly or via increased production of ROS. We propose that since endothelial stress and increases in platelet activity precede inflammation and overt symptoms of the MS, they are likely the first hit. This suggests that endothelial activation and insulin resistance are probably causative in the observed chronic low-level metabolic inflammation, and thus both metabolic and cardiovascular complications linked to consumption of a western diet.
  • Introduction: thymus development and function in health and disease
    Item type: Other Journal Item
    Holländer, Georg A. (2021)
    Seminars in Immunopathology
  • The mucosal firewalls against commensal intestinal microbes
    Item type: Journal Article
    Macpherson, Andrew J.; Slack, Emma; Geuking, Markus B.; et al. (2009)
    Seminars in Immunopathology
  • Heterogeneity of tissue-resident immunity across organs and in health and disease
    Item type: Other Journal Item
    Arck, Petra Clara; Sallusto, Federica (2022)
    Seminars in Immunopathology
Publications 1 - 6 of 6