Journal: Biomacromolecules

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American Chemical Society

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ISSN

1525-7797
1526-4602

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Publications1 - 10 of 97
  • Squid Suckerin Biomimetic Peptides Form Amyloid-like Crystals with Robust Mechanical Properties
    Item type: Journal Article
    Hiew, Shu Hui; Sánchez-Ferrer, Antoni; Amini, Shahrouz; et al. (2017)
    Biomacromolecules
  • Self-Healing Fish Gelatin/Sodium Montmorillonite Biohybrid Coacervates
    Item type: Journal Article
    Qazvini, Nader Taheri; Bolisetty, Sreenath; Adamcik, Jozef; et al. (2012)
    Biomacromolecules
  • Cross-Linking Chemistry of Tyramine-Modified Hyaluronan Hydrogels Alters Mesenchymal Stem Cell Early Attachment and Behavior
    Item type: Journal Article
    Loebel, Claudia; Szczesny, Spencer E.; Cosgrove, Brian D.; et al. (2017)
    Biomacromolecules
  • Recombinant Protein-co-PEG Networks as Cell-Adhesive and Proteolytically Degradable Hydrogel Matrixes. Part II: Biofunctional Characteristics
    Item type: Journal Article
    Rizzi, Simone C.; Ehrbar, Martin; Halstenberg, Sven; et al. (2006)
    Biomacromolecules
    We present here the biological performance in supporting tissue regeneration of hybrid hydrogels consisting of genetically engineered protein polymers that carry specific features of the natural extracellular matrix, cross-linked with reactive poly(ethylene glycol) (PEG). Specifically, the protein polymers contain the cell adhesion motif RGD, which mediates integrin receptor binding, and degradation sites for plasmin and matrix-metalloproteinases, both being proteases implicated in natural matrix remodeling. Biochemical assays as well as in vitro cell culture experiments confirmed the ability of these protein-PEG hydrogels to promote specific cellular adhesion and to exhibit degradability by the target enzymes. Cell culture experiments demonstrated that proteolytic sensitivity and suitable mechanical properties were critical for three-dimensional cell migration inside these synthetic matrixes. In vivo, protein-PEG matrixes were tested as a carrier of bone morphogenetic protein (rhBMP-2) to heal critical-sized defects in a rat calvarial defect model. The results underscore the importance of fine-tuning material properties of provisional therapeutic matrixes to induce cellular responses conducive to tissue repair. In particular, a lack of rhBMP or insufficient degradability of the protein-PEG matrix prevented healing of bone defects or remodeling and replacement of the artificial matrix. This work confirms the feasibility of attaining desired biological responses in vivo by engineering material properties through the design of single components at the molecular level. The combination of polymer science and recombinant DNA technology emerges as a powerful tool for the development of novel biomaterials.
  • Enhanced plastic deformations of nanofibrillated cellulose film by adsorbed moisture and protein-mediated interactions
    Item type: Journal Article
    Malho, Jani-Markus; Ouellet-Plamondon, Claudiane; Rüggeberg, Markus; et al. (2015)
    Biomacromolecules
  • Assembly of Cellulose Nanocrystal–Lysozyme Composite Films with Varied Lysozyme Morphology
    Item type: Journal Article
    De France, Kevin J.; Kummer, Nico; Ren, Qun; et al. (2020)
    Biomacromolecules
    In modern society, there is a constant need for developing reliable, sustainable, and cost-effective antibacterial materials. Here, we investigate the preparation of cellulose nanocrystal (CNC)–lysozyme composite films via the well-established method of evaporation-induced self-assembly. We consider the effects of lysozyme concentration and aggregation state (native lysozyme, lysozyme amyloid fibers, and sonicated lysozyme amyloid fibers) on suspension aggregation and film-forming ability. Although at higher lysozyme loading levels (ca. 10 wt %), composite films lost their characteristic chiral nematic structuring, these films demonstrated improved mechanical properties and antibacterial activity with respect to CNC-only films, regardless of lysozyme aggregation state. We anticipate that the results presented herein could also contribute to the preparation of other CNC–protein-based materials, including films, hydrogels, and aerogels, with improved mechanical performance and antibacterial activity.
  • Anomalous Stiffening and Ion-Induced Coil-Helix Transition of Carrageenans under Monovalent Salt Conditions
    Item type: Journal Article
    Schefer, Larissa; Usov, Ivan; Mezzenga, Raffaele (2015)
    Biomacromolecules
  • Contribution of Electrostatics in the Fibril Stability of a Model Ionic-Complementary Peptide
    Item type: Journal Article
    Owczarz, Marta; Casalini, Tommaso; Motta, Anna C.; et al. (2015)
    Biomacromolecules
  • Zwitterionic Polyester-Based Nanoparticles with Tunable Size, Polymer Molecular Weight, and Degradation Time
    Item type: Journal Article
    Capasso Palmiero, Umberto; Maraldi, Matteo; Manfredini, Nicolo; et al. (2018)
    Biomacromolecules
  • A Modular Platform for Cytocompatible Hydrogels with Tailored Mechanical Properties Based on Monolithic Matrices and Particulate Building Blocks
    Item type: Journal Article
    Andrée, Lea; Bertsch, Pascal; Wang, Rong; et al. (2023)
    Biomacromolecules
    We establish a versatilehydrogel platform based on modularbuildingblocks that allows the design of hydrogels with tailored physicalarchitecture and mechanical properties. We demonstrate its versatilityby assembling (i) a fully monolithic gelatin methacryloyl (Gel-MA)hydrogel, (ii) a hybrid hydrogel composed of 1:1 Gel-MA and gelatinnanoparticles, and (iii) a fully particulate hydrogel based on methacryloyl-modifiedgelatin nanoparticles. The hydrogels were formulated to exhibit thesame solid content and comparable storage modulus but different stiffnessand viscoelastic stress relaxation. The incorporation of particlesresulted in softer hydrogels with enhanced stress relaxation. Murineosteoblastic cells cultured in two-dimensional (2D) on hydrogels showedproliferation and metabolic activity comparable to established collagenhydrogels. Furthermore, the osteoblastic cells showed a trend of increasedcell numbers, cell expansion, and more defined protrusions on stifferhydrogels. Hence, modular assembly allows the design of hydrogelswith tailored mechanical properties and the potential to alter cellbehavior.
Publications1 - 10 of 97