Journal: Cancer Treatment Reviews

Abbreviation

Cancer Treat Rev

Publisher

Elsevier

Journal Volumes

ISSN

0305-7372

Description

Filters

20221
Reset filters

Search Results

Publications 1 - 1 of 1
  • Emerging antibody-based therapies for the treatment of acute myeloid leukemia
    Item type: Review Article
    Angenendt, Linus; Mikesch, Jan-Henrik; Schliemann, Christoph (2022)
    Cancer Treatment Reviews
    The development of antibody-based therapeutics for patients with acute myeloid leukemia (AML) has long been hampered due to the shared expression of antigens on leukemic blasts and hematopoietic stem and progenitor cells (HSPC). Nevertheless, the first antibody-drug conjugate has been approved for the treatment of AML in the recent years. In addition, multiple antibody-based therapeutics including antibody-drug conjugates, bispecific antibodies and immunocytokines are currently being developed in clinical trials with some of them demonstrating encouraging results alone and/or in combination with current standard therapies. In this review we discuss current concepts of antibody-based therapies and results from emerging antibody-based therapeutics for the treatment of AML.
Publications 1 - 1 of 1