Journal: Pharmacological research

Abbreviation

Pharmacol. res. (Print)

Publisher

Elsevier

Journal Volumes

ISSN

1043-6618
1096-1186

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2008 - 200922010 - 20203
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Publications 1 - 5 of 5
  • Oxidative stress in normal and impaired wound repair
    Item type: Review Article
    Schaefer, Matthias; Werner, Sabine (2008)
    Pharmacological research
  • Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction
    Item type: Journal Article
    Alfieri, Alessio; Ong, Albert C.M.; Kammerer, Richard A.; et al. (2014)
    Pharmacological research
  • Boswellic acids target the human immune system-modulating antimicrobial peptide LL-37
    Item type: Journal Article
    Henkel, Arne; Tausch, Lars; Pillong, Max; et al. (2015)
    Pharmacological research
  • Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system
    Item type: Review Article
    Quitterer, Ursula; AbdAlla, Said (2020)
    Pharmacological research
    With ageing of the global society, the frequency of ageing-related neurodegenerative diseases such as Alzheimer`s disease (AD) is on the rise worldwide. Currently, there is no cure for AD, and the four drugs approved for AD only have very small effects on AD symptoms. Consequently, there are enormous efforts worldwide to identify new targets for treatment of AD. Approaches that interfere with classical neuropathologic features of AD, such as extracellular senile plaques formed of aggregated amyloid-beta (Abeta), and intracellular neurofibrillary tangles of hyperphosphorylated tau have not been successful so far. In search for a treatment approach of AD, we found that inhibition of the angiotensin-converting enzyme (ACE) by a centrally acting ACE inhibitor retards symptoms of neurodegeneration, Abeta plaque formation and tau hyperphosphorylation in experimental models of AD. Our approach is currently being investigated in a clinical setting. Initial evidence with AD patients shows that a brain-penetrating ACE inhibitor counteracts the process of neurodegeneration and dementia. Moreover, centrally acting ACE inhibitors given in addition to the standard therapy, cholinesterase inhibition, can improve cognitive function of AD patients for several months. This is one of the most promising results for AD treatment since more than a decade.
  • Gender perspectives in European research
    Item type: Journal Article
    Klinge, Ineke (2008)
    Pharmacological research
    Background Attention to sex and gender aspects in biomedical and health-related research has been a major initiative of the EU gender equality policy for research. The EU funded GenderBasic project (2005–2008), conceived to stimulate this attention to sex and gender and to provide practical tools to researchers, resulted in the publication of 10 reviews by high-level scientists in a Supplement to Gender Medicine in December 2007: “Bringing Gender Expertise to Biomedical and Health-Related Research”. Methods Four commissioned reviews covered methodological aspects of addressing sex and gender in biomedical research – ranging from basic, molecular to public health research – next to six reviews that addressed sex and gender aspects relevant to selected health areas: anxiety disorders, asthma, metabolic syndrome, nutrigenomics, osteoporosis and work-related health. Results The review articles, that were discussed at an expert meeting, attended – upon invitation – by a mixed audience of basic and clinical researchers, epidemiologists, social scientists and gender researchers, came up with excellent state of the art data, solutions to methodological and conceptual problems, practical tools and interesting questions for further research. Conclusion The expert meeting created great enthusiasm among the participants and a real exchange took place among researchers from various backgrounds. Most life sciences researchers were familiar with the concept of sex differences but confessed that the effects of socially constructed gender until now, had received too little attention. The GenderBasic project yielded three major achievements for European research: (1) it stimulated and promoted research into sex differences; (2) it stimulated research into the workings of gender, illustrated by useful examples in particular in understanding masculinity and its effects on the health of individual men; (3) it highlighted sex-gender interaction and granted gender a prominent place on the research agenda that resulted from GenderBasic. A final conclusion of the project was that it is not differences per se that are interesting but rather how, as a result of the interaction between sex and gender, differences develop. The European Commission selected the GenderBasic project itself as an excellent example of the positive impacts EU research can achieve and the project will be featured in a catalogue of 6th Framework Success Stories. © 2008 Elsevier Ltd.
Publications 1 - 5 of 5