Journal: Advanced Healthcare Materials

Abbreviation

Adv. Healthcare Mater.

Publisher

Wiley-VCH

Journal Volumes

ISSN

2192-2640
2192-2659

Description

Filters

2013 - 2019242020 - 202640
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Publications 1 - 10 of 64
  • Reinforced Polymer-Nanoparticle Hydrogels for Subcutaneous and Sustained Delivery of Trastuzumab
    Item type: Journal Article
    Bovone, Giovanni; Bernhard, Stéphane; Jacquot, Guillaume; et al. (2025)
    Advanced Healthcare Materials
    In oncology, the advent of monoclonal antibody (mAb) therapeutics represents a breakthrough in various cancer diseases. However, these therapies often necessitate iterative hospital visits for intravenous infusion that alter patient quality of life and contribute to the chronic saturation of hospitals. Subcutaneous formulations of mAbs offer a promising alternative facilitating faster administration compared with traditional intravenous methods, while still maintaining the same dosing schedule and providing time-saving advantages. Here, an injectable mAb delivery platform using alpha-cyclodextrin (alpha CD)-reinforced polymer-nanoparticle hydrogels to perform subcutaneous mAb depots and delay their release is developed. By leveraging mAb-polymer electrostatic complexation, hyaluronic acid- and alginate-based injectable drug depots are formulated by simply mixing components that are generally regarded as safe. Trastuzumab is included as a clinically relevant therapeutic antibody. These formulations delayed mAb release both in vitro and in vivo mice models, with a similar pharmacokinetic performance to the clinically approved Herceptin SC (Roche) formulation composed of trastuzumab with recombinant human hyaluronidase (rHuPH20).
  • Perfusable Biohybrid Designs for Bioprinted Skeletal Muscle Tissue
    Item type: Journal Article
    Filippi, Miriam; Yasa, Öncay; Giachino, Jan; et al. (2023)
    Advanced Healthcare Materials
    Engineered, centimeter-scale skeletal muscle tissue (SMT) can mimic muscle pathophysiology to study development, disease, regeneration, drug response, and motion. Macroscale SMT requires perfusable channels to guarantee cell survival, and support elements to enable mechanical cell stimulation and uniaxial myofiber formation. Here, stable biohybrid designs of centimeter-scale SMT are realized via extrusion-based bioprinting of an optimized polymeric blend based on gelatin methacryloyl and sodium alginate, which can be accurately coprinted with other inks. A perfusable microchannel network is designed to functionally integrate with perfusable anchors for insertion into a maturation culture template. The results demonstrate that i) coprinted synthetic structures display highly coherent interfaces with the living tissue, ii) perfusable designs preserve cells from hypoxia all over the scaffold volume, iii) constructs can undergo passive mechanical tension during matrix remodeling, and iv) the constructs can be used to study the distribution of drugs. Extrusion-based multimaterial bioprinting with the inks and design realizes in vitro matured biohybrid SMT for biomedical applications.
  • Synthetic Antiferromagnetic Designer Nanodisks for High-Performance Magnetic Separation
    Item type: Journal Article
    Scheibler, Subas; Habermann, Sebastian; Gogos, Alexander; et al. (2025)
    Advanced Healthcare Materials
    Magnetic separation of magnetic particles offers an appealing route to rapid and selective target capturing and isolation. However, to leverage such an approach to its full potential, high colloidal stability of the nanoparticles in the absence of a magnetic field for optimal binding, and rapid and quantitative recovery upon magnetic gradient field application are imperative. While these properties are mutually exclusive for conventional nanoparticles synthesized by wet-chemistry approaches, sputter deposition gives access to layered architectures featuring the properties of a synthetic antiferromagnet (SAF, no magnetization in zero field, high magnetization upon field application). Here, micromagnetic-modelling based design optimization and scalable manufacturing of metallic CoSm-based, metal oxide-capped SAF magnetic disk particles (SAF MDPs) with high chemical and colloidal stability and cytocompatibility are presented. It is demonstrated that the SAF MDPs can be rapidly and much more efficiently separated (> 99%) from flowing fluids (approx. 1 mL/min) compared to corresponding gold standard iron oxide beads (60% recovery), paving the way to quantitative capturing and enrichment of target compounds in high-throughput conditions compliant with clinical and industrial applications.
  • Chitosan Electrodeposition for Microrobotic Drug Delivery
    Item type: Journal Article
    Fusco, Stefano; Chatzipirpiridis, George; Sivaraman, Kartik M.; et al. (2013)
    Advanced Healthcare Materials
  • Skin Conformal Polymer Electrodes for Clinical ECG and EEG Recordings
    Item type: Journal Article
    Stauffer, Flurin; Thielen, Moritz; Sauter, Christina Julia; et al. (2018)
    Advanced Healthcare Materials
  • Electroforming of Implantable Tubular Magnetic Microrobots for Wireless Ophthalmologic Applications
    Item type: Journal Article
    Chatzipirpiridis, George; Ergeneman, Olgaç; Pokki, Juho; et al. (2015)
    Advanced Healthcare Materials
  • Silica Microcapsules for Long-Term, Robust, and Reliable Room Temperature RNA Preservation
    Item type: Journal Article
    Puddu, Michela; Stark, Wendelin J.; Grass, Robert N. (2015)
    Advanced Healthcare Materials
  • A Capsule-Type Microrobot with Pick-and-Drop Motion for Targeted Drug and Cell Delivery
    Item type: Journal Article
    Lee, Seungmin; Kim, Soyeun; Kim, Sangwon; et al. (2018)
    Advanced Healthcare Materials
  • Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering
    Item type: Journal Article
    Klein Gunnewiek, Michel; Di Luca, Andrea; Bollemaat, Hermannes Z.; et al. (2015)
    Advanced Healthcare Materials
  • In Situ Synchrotron X-Ray Diffraction Characterization of Corrosion Products of a Ti-Based Metallic Glass for Implant Applications
    Item type: Journal Article
    Gostin, Petre Flaviu; Addison, Owen; Morrell, Alexander P.; et al. (2018)
    Advanced Healthcare Materials
Publications 1 - 10 of 64