Journal of Chromatography A

Journal: Journal of Chromatography A

Publisher

Elsevier

ISSN

0021-9673

Show all metadata

Search Results

Publications 1 - 10 of 132

Experimental design of a twin-column countercurrent gradient purification process
Steinebach, Fabian; Ulmer, Nicole; Decker, Lara; et al. (2017)
Journal of Chromatography A
Foreword
Morbidelli, Massimo (2009)
Journal of Chromatography A
Inverse supercritical fluid extraction as a sample preparation method for the analysis of the nanoparticle content in sunscreen agents
Müller, David; Cattaneo, Stefano; Meier, Florian; et al. (2016)
Journal of Chromatography A
Experimental implementation of automatic 'cycle to cycle' control of a chiral simulated moving bed separation
Amanullah, Mohammad; Grossmann, Cristian; Mazzotti, Marco; et al. (2007)
Journal of Chromatography A
Simultaneous quantification of polar and non-polar volatile organic compounds in water samples by direct aqueous injection-gas chromatography/mass spectrometry
Aeppli, Christoph; Berg, Michael; Hofstetter, Thomas B.; et al. (2008)
Journal of Chromatography A
Optimizing control of simulated moving beds
Abel, Stefanie; Erdem, Gültekin; Mazzotti, Marco; et al. (2004)
Journal of Chromatography A
Design space and robustness analysis of batch and counter-current frontal chromatography processes for the removal of antibody aggregates
Vogg, Sebastian; Müller-Späth, Thomas; Morbidelli, Massimo (2020)
Journal of Chromatography A
Interconversion and chromatographic separation of carbohydrate stereoisomers on polystyrene-divinylbenzene resins
Ortner, Franziska; Wiemeyer, Helena; Mazzotti, Marco (2017)
Journal of Chromatography A
Mutarotation of sugars causes distorted and splitted peaks in liquid chromatography. The shape of the elution profile is affected by the different anomeric and isomeric forms in solution. The rate of interconversion between the different forms relative to the propagation velocity in the column determines the extent of the distortion. This interplay of interconversion reaction and chromatographic separation was examined both experimentally and theoretically. Elution profiles resulting from pulse injections of glucose and fructose solutions at different flow rates and temperatures were analyzed both qualitatively and quantitatively. Adsorption equilibrium and reaction kinetic parameters were estimated by a simple fitting procedure, based on peak elution times and area ratios obtained from the analysis of the experimental profiles. To enhance the accuracy of the model parameters further, estimated reaction kinetic parameters were provided as an initial guess for inverse fitting to elution profiles, using a numeric mass balance model. Simulations with the numeric model, based on the enhanced parameters, allowed a very precise description of the experimental profiles. Accuracy of the fitted parameters was further confirmed through comparison with literature values. Reaction rate constants for the adsorbed phase were calculated and interpreted based on apparent rate constant values determined in this work, and on literature data for aqueous solutions.
Model-based description of peptide retention on doped reversed-phase media
Khalaf, Rushd; Forrer, Nicola; Buffolino, Gianluca; et al. (2015)
Journal of Chromatography A
Chromatographic behavior of a plyclonal antibody mixture on a strong cation exchanger column. Part I
Forrer, Nicola; Butté, Alessandro; Morbidelli, Massimo (2008)
Journal of Chromatography A

Publications 1 - 10 of 132

Journal: Journal of Chromatography A

Abbreviation

Publisher

Journal Volumes

ISSN

Description

Filters

Search Results