ChemMedChem

Journal: ChemMedChem

Abbreviation

ChemMedChem

Publisher

Wiley

ISSN

1860-7179
1860-7187

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Publications 1 - 10 of 52

Efficient Stacking on Protein Amide Fragments
Harder, Michael; Kuhn, Bernd; Diederich, François (2013)
ChemMedChem
Isolation of a Small-Molecule Inhibitor of the Antiapoptotic Protein Bcl-xL from a DNA-Encoded Chemical Library
Melkko, Samu; Mannocci, Luca; Dumelin, Christoph E.; et al. (2010)
ChemMedChem
Fluorinated GluN2B Receptor Antagonists with a 3-Benzazepine Scaffold Designed for PET Studies
Szermerski, Marina; Börgel, Frederik; Schepmann, Dirk; et al. (2018)
ChemMedChem
Selective Fragments for the CREBBP Bromodomain Identified from an Encoded Self‐assembly Chemical Library
Catalano, Marco; Moroglu, Mustafa; Balbi, Petra; et al. (2020)
ChemMedChem
DNA‐encoded chemical libraries (DECLs) are collections of chemical moieties individually coupled to distinctive DNA barcodes. Compounds can be displayed either at the end of a single DNA strand (i. e., single‐pharmacophore libraries) or at the extremities of two complementary DNA strands (i. e., dual‐pharmacophore libraries). In this work, we describe the use of a dual‐pharmacophore encoded self‐assembly chemical (ESAC) library for the affinity maturation of a known 4,5‐dihydrobenzodiazepinone ring (THBD) acetyl‐lysine (KAc) mimic for the cyclic‐AMP response element binding protein (CREB) binding protein (CREBBP or CBP) bromodomain. The new pair of fragments discovered from library selection showed a sub‐micromolar affinity for the CREBBP bromodomain in fluorescence polarization and ELISA assays, and selectivity against BRD4(1). © 2020 Wiley-VCH GmbH.
The Binding Mode of Side Chain- and C3-Modified Epothilones to Tubulin
Erdélyi, Máté; Navarro-Vázquez, Armando; Pfeiffer, Bernhard; et al. (2010)
ChemMedChem
Potent and Selective Inhibition of Cysteine Proteases from Plasmodium falciparum and Trypanosoma brucei
Ehmke, Veronika; Heindl, Cornelia; Rottmann, Matthias; et al. (2011)
ChemMedChem
Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold
Schwertz, Geoffrey; Witschel, Matthias C.; Rottmann, Matthias; et al. (2018)
ChemMedChem
[18F]Flurpiridaz: Facile and Improved Precursor Synthesis for this Next‐Generation Cardiac Positron Emission Tomography Imaging Agent
Ahmed, Hazem; Haider, Ahmed; Gisler, Livio; et al. (2020)
ChemMedChem
From Machine Learning to Natural Product Derivatives that Selectively Activate Transcription Factor PPARγ
Rupp, Matthias; Schroeter, Timon; Steri, Ramona; et al. (2010)
ChemMedChem
Binding to Large Enzyme Pockets: Small-Molecule Inhibitors of Trypanothione Reductase
Persch, Elke; Bryson, Steve; Todoroff, Nickolay K.; et al. (2014)
ChemMedChem

Publications 1 - 10 of 52

Journal: ChemMedChem

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