Journal of Allergy and Clinical Immunology

Journal: Journal of Allergy and Clinical Immunology

Abbreviation

J Allergy Clin Immunol

Publisher

Mosby

ISSN

0091-6749
1097-6825

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Publications 1 - 7 of 7

Dynamics of the nasal microbiota in infancy: A prospective cohort study
Mika, Moana; Mack, Ines; Korten, Insa; et al. (2015)
Journal of Allergy and Clinical Immunology
Background Understanding the composition and dynamics of the upper respiratory tract microbiota in healthy infants is a prerequisite to investigate the role of the microbiota in patients with respiratory diseases. This is especially true in early life, when the immune system is in development. Objective We sought to describe the dynamics of the upper respiratory tract microbiota in healthy infants within the first year of life. Methods After exclusion of low-quality samples, microbiota characterization was performed by using 16S rDNA pyrosequencing of 872 nasal swabs collected biweekly from 47 unselected infants. Results Bacterial density increased and diversity decreased within the first year of life (R2 = 0.95 and 0.73, respectively). A distinct profile for the first 3 months of life was found with increased relative abundances of Staphlyococcaceae and Corynebacteriaceae (exponential decay: R2 = 0.94 and 0.96, respectively). In addition, relative bacterial abundance and composition differed significantly from summer to winter months. The individual composition of the microbiota changed with increasing time intervals between samples and was best modeled by an exponential function (R2 = 0.97). Within-subject dissimilarity in a 2-week time interval was consistently lower than that between subjects, indicating a personalized microbiota. Conclusion This study reveals age and seasonality as major factors driving the composition of the nasal microbiota within the first year of life. A subject's microbiota is personalized but dynamic throughout the first year. These data are indispensable to interpretation of cross-sectional studies and investigation of the role of the microbiota in both healthy subjects and patients with respiratory diseases. They might also serve as a baseline for future intervention studies.
Relations between epidermal barrier dysregulation and Staphylococcus species–dominated microbiome dysbiosis in patients with atopic dermatitis
Altunbulakli, Can; Reiger, Matthias; Neumann, Avidan U.; et al. (2018)
Journal of Allergy and Clinical Immunology
Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1)
Schubert, Desirée; Klein, Marie-Christine; Hassdenteufel, Sarah; et al. (2018)
Journal of Allergy and Clinical Immunology
Modulation of allergic responses in mice by using biodegradable poly(lactide-co-glycolide) microspheres
Jilek, Samantha; Walter, Elke; Merkle, Hans P.; et al. (2004)
Journal of Allergy and Clinical Immunology
Histamine 2-receptor is a key influence in immune responses to intestinal histamine-secreting microbes
Ferstl, Ruth; Frei, Remo; Schiavi, Elisa; et al. (2014)
Journal of Allergy and Clinical Immunology
Splicing defect of CD33 and inflammatory syndrome associated with occult bacterial infection
Balmer, Maria L.; Trüeb, Beat; Zhuang, Lei; et al. (2013)
Journal of Allergy and Clinical Immunology
GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation.
Nobs, Samuel P.; Kayhan, Merve; Kopf, Manfred (2019)
Journal of Allergy and Clinical Immunology

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