Journal: Journal of Allergy and Clinical Immunology
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Abbreviation
J Allergy Clin Immunol
Publisher
Mosby
7 results
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Publications 1 - 7 of 7
- Dynamics of the nasal microbiota in infancy: A prospective cohort studyItem type: Journal Article
Journal of Allergy and Clinical ImmunologyMika, Moana; Mack, Ines; Korten, Insa; et al. (2015)Background Understanding the composition and dynamics of the upper respiratory tract microbiota in healthy infants is a prerequisite to investigate the role of the microbiota in patients with respiratory diseases. This is especially true in early life, when the immune system is in development. Objective We sought to describe the dynamics of the upper respiratory tract microbiota in healthy infants within the first year of life. Methods After exclusion of low-quality samples, microbiota characterization was performed by using 16S rDNA pyrosequencing of 872 nasal swabs collected biweekly from 47 unselected infants. Results Bacterial density increased and diversity decreased within the first year of life (R2 = 0.95 and 0.73, respectively). A distinct profile for the first 3 months of life was found with increased relative abundances of Staphlyococcaceae and Corynebacteriaceae (exponential decay: R2 = 0.94 and 0.96, respectively). In addition, relative bacterial abundance and composition differed significantly from summer to winter months. The individual composition of the microbiota changed with increasing time intervals between samples and was best modeled by an exponential function (R2 = 0.97). Within-subject dissimilarity in a 2-week time interval was consistently lower than that between subjects, indicating a personalized microbiota. Conclusion This study reveals age and seasonality as major factors driving the composition of the nasal microbiota within the first year of life. A subject's microbiota is personalized but dynamic throughout the first year. These data are indispensable to interpretation of cross-sectional studies and investigation of the role of the microbiota in both healthy subjects and patients with respiratory diseases. They might also serve as a baseline for future intervention studies. - Relations between epidermal barrier dysregulation and Staphylococcus species–dominated microbiome dysbiosis in patients with atopic dermatitisItem type: Other Journal Item
Journal of Allergy and Clinical ImmunologyAltunbulakli, Can; Reiger, Matthias; Neumann, Avidan U.; et al. (2018) - Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1)Item type: Journal Article
Journal of Allergy and Clinical ImmunologySchubert, Desirée; Klein, Marie-Christine; Hassdenteufel, Sarah; et al. (2018) - Modulation of allergic responses in mice by using biodegradable poly(lactide-co-glycolide) microspheresItem type: Journal Article
Journal of Allergy and Clinical ImmunologyJilek, Samantha; Walter, Elke; Merkle, Hans P.; et al. (2004) - Histamine 2-receptor is a key influence in immune responses to intestinal histamine-secreting microbesItem type: Journal Article
Journal of Allergy and Clinical ImmunologyFerstl, Ruth; Frei, Remo; Schiavi, Elisa; et al. (2014) - Splicing defect of CD33 and inflammatory syndrome associated with occult bacterial infectionItem type: Other Journal Item
Journal of Allergy and Clinical ImmunologyBalmer, Maria L.; Trüeb, Beat; Zhuang, Lei; et al. (2013) - GM-CSF intrinsically controls eosinophil accumulation in the setting of allergic airway inflammation.Item type: Journal Article
Journal of Allergy and Clinical ImmunologyNobs, Samuel P.; Kayhan, Merve; Kopf, Manfred (2019)
Publications 1 - 7 of 7