Biomedical Materials

Journal: Biomedical Materials

Abbreviation

Biomed. Mater.

Publisher

IOP Publishing

ISSN

1748-6041
1748-6041
1748-605X

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Publications1 - 10 of 11

A simplified fabrication technique for cellularized high-collagen dermal equivalents
Fox, Stephan Cecil; Biedermann, Thomas; Polak, Jessica; et al. (2019)
Biomedical Materials
Effects of deer age on the physicochemical properties of deproteinized antler cancellous bone: an approach to optimize osteoconductivity of bone graft
Meng, Song; Zhang, Xuehui; Xu, Mingming; et al. (2015)
Biomedical Materials
Tyrosinase-crosslinked, tissue adhesive and biomimetic alginate sulfate hydrogels for cartilage repair
Öztürk, Ece; Stauber, Tino; Levinson, Clara; et al. (2020)
Biomedical Materials
The native cartilage extracellular matrix (ECM) is enriched in sulfated glycosaminoglycans with important roles in the signaling and phenotype of resident chondrocytes. Recapitulating the key ECM components within engineered tissues through biomimicking strategies has potential to improve the regenerative capacity of encapsulated cells and lead to better clinical outcome. Here, we developed a double-modified, biomimetic and tissue adhesive hydrogel for cartilage engineering. We demonstrated sequential modification of alginate with first sulfate moieties to mimic the high glycosaminoglycan content of native cartilage and then tyramine moieties to allow in situ enzymatic crosslinking with tyrosinase under physiological conditions. Tyrosinase-crosslinked alginate sulfate tyramine (ASTA) hydrogels showed strong adhesion to native cartilage tissue with higher bond strength compared to alginate tyramine (AlgTA). Both ASTA and AlgTA hydrogels supported the viability of encapsulated bovine chondrocytes and induced a strong increase in the expression of chondrogenic genes such as collagen 2, aggrecan and Sox9. Aggrecan and Sox9 gene expression of chondrocytes in ASTA hydrogels were significantly higher than those in AlgTA. Chondrocytes in both ASTA and AlgTA hydrogels showed potent deposition of cartilage matrix components collagen 2 and aggrecan after 3 weeks of culture whereas a decreased collagen 1 deposition was observed in the sulfated hydrogels. ASTA and AlgTA hydrogels with encapsulated human chondrocytes showed in vivo stability as well as cartilage matrix deposition upon subcutaneous implantation into mice for 4 weeks. Our data is the first demonstration of a double-modified alginate with sulfation and tyramination that allows in situ enzymatic crosslinking, strong adhesion to native cartilage and chondrogenic re-differentiation. (© 2020 IOP Publishing Ltd.)
Histological and histomorphometrical analysis of a silica matrix embedded nanocrystalline hydroxyapatite bone substitute using the subcutaneous implantation model in Wistar rats
Ghanaati, Shahram; Orth, Carina; Barbeck, Mike; et al. (2010)
Biomedical Materials
The clinical suitability of a bone substitute material is determined by the ability to induce a tissue reaction specific to its composition. The aim of this in vivo study was to analyze the tissue reaction to a silica matrix-embedded, nanocrystalline hydroxyapatite bone substitute. The subcutaneous implantation model in Wistar rats was chosen to assess the effect of silica degradation on the vascularization of the biomaterial and its biodegradation within a time period of 6 months. Already at day 10 after implantation, histomorphometrical analysis showed that the vascularization of the implantation bed reached its peak value compared to all other time points. Both vessel density and vascularization significantly decreased until day 90 after implantation. In this time period, the bone substitute underwent a significant degradation initiated by TRAP-positive and TRAP-negative multinucleated giant cells together with macrophages and lymphocytes. Although no specific tissue reaction could be related to the described silica degradation, the biomaterial was close to being fully degraded without a severe inflammatory response. These characteristics are advantageous for bone regeneration and remodeling processes.
Nanocomposites of high-density polyethylene with amorphous calcium phosphate
Hild, Nora; Fuhrer, Roland; Mohn, Dirk; et al. (2012)
Biomedical Materials
MEMS capacitive force sensors for cellular and flight biomechanics
Sun, Yu; Nelson, Bradley J. (2007)
Biomedical Materials
Corrigendum: Alginate dependent changes of physical properties in 3D bioprinted cell-laden porous scaffolds affect cell viability and cell morphology (2019 Biomed. Mater. 14 065009)
Zhang, Jianhua; Wehrle, Esther; Vetsch, Jolanda; et al. (2023)
Biomedical Materials
Alginate dependent changes of physical properties in 3D bioprinted cell-laden porous scaffolds affect cell viability and cell morphology
Zhang, Jianhua; Wehrle, Esther; Vetsch, Jolanda; et al. (2019)
Biomedical Materials
Sub-micron lateral topography affects endothelial migration by modulation of focal adhesion dynamics
Antonini, S.; Meucci, S.; Jacchetti, E.; et al. (2015)
Biomedical Materials
Collagen-embedded hydroxylapatite-beta-tricalcium phosphate-silicon dioxide bone substitute granules assist rapid vascularization and promote cell growth
Ghanaati, Shahram M.; Thimm, Benjamin W.; Unger, Ronald E.; et al. (2010)
Biomedical Materials

Publications1 - 10 of 11

Journal: Biomedical Materials

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