Journal: Chemistry & Biodiversity

Abbreviation

Chem. biodivers.

Publisher

Verlag Helvetica Chimica Acta

Journal Volumes

ISSN

1612-1872
1612-1880

Description

Filters

2006 - 200915
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Publications 1 - 10 of 15
  • Reactions of the HCN-Tetramer with Aldehydes
    Item type: Journal Article
    Koch, Klemens; Schweizer, W. Bernd; Eschenmoser, Albert (2007)
    Chemistry & Biodiversity
  • Synthesis and characterization of a C(6) nucleoside analogue for the in vivo imaging of the gene expression of herpes simplex virus type-1 thymidine kinase (HSV1 TK)
    Item type: Journal Article
    Johayem, Anass; Raić-Malić, Silvana; Lazzati, Katia; et al. (2006)
    Chemistry & Biodiversity
  • The Biochemistry of Drug Metabolism – An Introduction: Part 7. Intra-Individual Factors Affecting Drug Metabolism
    Item type: Review Article
    Krämer, Stefanie-Dorothea; Testa, Bernard (2009)
    Chemistry & Biodiversity
    This review on intra-individual factors affecting drug metabolism completes our series on the biochemistry of drug metabolism. The article presents the molecular mechanisms causing intra-individual differences in enzyme expression and activity. They include enzyme induction by transcriptional activation and enzyme inhibition on the protein level. The influencing factors are of physiological, pathological, or external origin. Tissue characteristics and developmental age strongly influence enzyme-expression patterns. Further influencing factors are pregnancy, disease, or biological rhythms. Xenobiotics, drugs, constituents of herbal remedies, food constituents, ethanol, and tobacco can all influence enzyme expression or activity and, hence, affect drug metabolism.
  • The Biochemistry of Drug Metabolism – An Introduction: Part 4. Reactions of Conjugation and Their Enzymes
    Item type: Review Article
    Testa, Bernard; Krämer, Stefanie-Dorothea (2008)
    Chemistry & Biodiversity
    This review continues a general presentation of the metabolism of drugs and other xenobiotics begun in three recent issues of Chemistry & Biodiversity. The present Part is dedicated to reactions of conjugation, namely methylation, sulfonation, and phosphorylation, glucuronidation and other glycosidations, acetylation and other acylations, the formation and fate of coenzyme A conjugates, glutathione conjugation, and the reaction of amines with carbonyl compounds. It presents the many transferases involved, their nomenclature, relevant biochemical properties, catalytic mechanisms, and the reactions they catalyze. Nonenzymatic reactions, mainly of glutathione conjugation, also receive due attention. A number of medicinally, environmentally, and toxicologically relevant examples are presented and discussed.
  • The biochemistry of drug metabolism - An introduction: Part 3. Reactions of Hydrolysis and Their Enzymes
    Item type: Review Article
    Testa, Bernard; Krämer, Stefanie-Dorothea (2007)
    Chemistry & Biodiversity
    This review continues a general presentation of the metabolism of drugs and other xenobiotics begun in two recent issues of Chemistry & Biodiversity. This Part presents some of the numerous hydrolases involved, their nomenclature, relevant biochemical properties, catalytic mechanisms, and the many reactions of hydrolysis they catalyze. A number of medicinally, environmentally, and toxicologically relevant examples are presented and discussed. The reactions examined include the hydrolysis of carboxylic esters, amides and peptides, lactones, and other labile rings, and esters of inorganic acids. The hydration of epoxides and its enzymology are treated separately.
  • The Biochemistry of Drug Metabolism – An Introduction: Part 1. Principles and Overview
    Item type: Review Article
    Testa, Bernard; Krämer, Stefanie-Dorothea (2006)
    Chemistry & Biodiversity
    This paper reviews the general principles and concepts underlying Drug and Xenobiotic Metabolism. Its five Chapters deal with: 1.1. Drugs and Xenobiotics, 1.2. What are Drug Disposition and Metabolism?, 1.3. Where does Drug Metabolism Occur?, 1.4. Consequences of Drug Metabolism -- An Overview, and 1.5. Drug Metabolism and Drug Discovery. This review is the first of seven Parts which will be published at intervals. The subsequent Parts will cover: 2. Redox Reactions and Their Enzymes, 3. Reactions of Hydrolysis and Their Enzymes, 4. Conjugation Reactions and Their Enzymes, 5. Metabolism and Bioactivity, 6. Inter-Individual Factors Affecting Drug Metabolism, and 7. Intra-Individual Factors Affecting Drug Metabolism.
  • The Biochemistry of Drug Metabolism – An Introduction: Part 2. Redox Reactions and Their Enzymes
    Item type: Review Article
    Testa, Bernard; Krämer, Stefanie-Dorothea (2007)
    Chemistry & Biodiversity
    This review continues a general presentation of the metabolism of drugs and other xenobiotics started in a recent issue of Chemistry & Biodiversity. This Part 2 presents the numerous oxidoreductases involved, their nomenclature, relevant biochemical properties, catalytic mechanisms, and the very diverse reactions they catalyze. Many medicinally, environmentally, and toxicologically relevant examples are presented and discussed. Cytochromes P450 occupy a majority of the pages of Part 2, but a large number of relevant oxidoreductases are also considered, e.g., flavin-containing monooxygenases, amine oxidases, molybdenum hydroxylases, peroxidases, and the innumerable dehydrogenases/reductases.
  • Lipid-bilayer permeation of drug-like compounds
    Item type: Review Article
    Krämer, Stefanie-Dorothea; Lombardi, Dario; Primorac, Adriana; et al. (2009)
    Chemistry & Biodiversity
    Lipid-bilayer permeation is determinant for the disposition of xenobiotics in the body. It controls the pharmacokinetic behavior of drugs and is, in many cases, a prerequisite for intracellular targeting. Permeation of in vivo barriers is in general predicted from lipophilicity and related parameters. This article goes beyond the empirical correlations, and elucidates the processes and their interplay determining bilayer permeation. A flip-flop model for bilayer permeation, which considers the partitioning rate constants beside the translocation rate constants, is compared with the diffusion model based on Fick’s first law. According to the flip-flop model, the ratios of aqueous volumes to barrier area can determine whether partitioning or translocation is rate-limiting. The flip-flop model allows permeation of anions and cations, and expands our understanding of pH-dependent permeation kinetics. Some experimental evidences for ion-controlled permeation at pH 7 are also included in this work.
  • Comparison of permeation through phosphatidylcholine bilayers of N-dipicolinyl-alpha- and -beta-oligopeptides
    Item type: Journal Article
    Gardiner, James; Thomae, Anita V.; Mathad, Raveendra I.; et al. (2006)
    Chemistry & Biodiversity
  • pH-Sensitive Vesicles Containing a Lipidic β-Amino Acid with Two Hydrophobic Chains
    Item type: Journal Article
    Capone, Stefania; Walde, Peter; Seebach, Dieter; et al. (2008)
    Chemistry & Biodiversity
Publications 1 - 10 of 15