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Journal: Bioengineering & Translational Medicine

Abbreviation

Bioeng. Trans. Med.

Publisher

Wiley

Journal Volumes

ISSN

2380-6761

Description

Filters

2017 - 201912020 - 20254
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Publications 1 - 5 of 5
  • Multiaxial rotational loading compromises the transition zone of the intervertebral disc: Ex vivo study using next-generation bioreactors
    Item type: Journal Article
    Šećerović, Amra; Ristaniemi, Aapo; Crivelli, Francesco; et al. (2025)
    Bioengineering & Translational Medicine
    Bioreactors have become indispensable tools in spine research, enabling long-term intervertebral disc culture under controlled biological and mechanical conditions. Conventional systems are often limited to uniaxial loading, restricting their ability to replicate the complex, multidirectional biomechanics of the spine. To overcome this limitation, we developed a next-generation bioreactor capable of simulating multiaxial motions while preserving the disc's biological environment. In this study, we investigated the effects of complex loading patterns on early disc degeneration by subjecting bovine whole-organ discs to combined extension, lateral bending, and torsion at 0.3 Hz for 2 h daily over 14 days. To assess the impact of loading magnitude and the specific contribution of torsion, discs were exposed to either low- or high-angle rotations, with or without torsional loading at higher angles. Histological analysis revealed a marked loss of glycosaminoglycans (GAG) and collagen type II within the inner annulus fibrosus and transitional nucleus pulposus (NP), encompassing the transition zone (TZ), as well as GAG depletion in the central NP. Matrix degradation was observed across all loading conditions, with the most severe breakdown occurring under high-angle extension, bending, and torsion. All loading regimes induced cell death in the TZ and central NP, although torsion-free loading better maintained cell viability. These findings highlight the TZ, alongside the commonly affected NP, as a critical early site of degeneration. The study further underscores the importance of incorporating multiaxial loading in disc degeneration models and provides new insights into the biomechanical mechanisms underlying disc pathology.
  • Efficacy of catheter-based drug delivery in a hybrid in vitro model of cardiac microvascular obstruction with porcine microthrombi
    Item type: Journal Article
    Rösch, Yannick; Stolte, Thorald; Weisskopf, Miriam; et al. (2024)
    Bioengineering & Translational Medicine
    Microvascular obstruction (MVO) often occurs in ST-elevation myocardial infarction (STEMI) patients after percutaneous coronary intervention (PCI). Diagnosis and treatment of MVO lack appropriate and established procedures. This study focused on two major points by using an in vitro multiscale flow model, which comprised an aortic root model with physiological blood flow and a microfluidic model of the microcirculation with vessel diameters down to 50 mu m. First, the influence of porcine microthrombi (MT), injected into the fluidic microchip, on perfusion was investigated. We found that only 43% of all injected MT were fully occlusive. Second, it could also be shown that the maximal concentration of a dye (representing therapeutic agent) during intracoronary infusion could be increased on average by 58%, when proximally occluding the coronary artery by a balloon during drug infusion. The obtained results and insights enhance the understanding of perfusion in MVO-affected micro circulation and could lead to improved treatment methods for MVO patients.
  • Introduction to Editorial Board Member: Professor Francis J. Doyle III
    Item type: Journal Article
    Bagheri, Neda; Gunawan, Rudiyanto (2017)
    Bioengineering & Translational Medicine
  • Screening method to identify hydrogel formulations that facilitate myotube formation from encapsulated primary myoblasts
    Item type: Journal Article
    Deshmukh, Dhananjay V.; Pasquero, Nils; Rathore, Gajraj; et al. (2020)
    Bioengineering & Translational Medicine
  • From lab to society: Fostering clinical translation of molecular systems engineering
    Item type: Journal Article
    Gonçalves Leonel da Silva, Renan; Blasimme, Alessandro (2024)
    Bioengineering & Translational Medicine
    Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialog is needed to build public trust and address potential ethical, societal, and regulatory challenges. In this essay, we discuss societal aspects linked to the clinical use of biomedical engineering approaches and technologies, with a specific focus on molecular systems engineering. Drawing on data from interviews with 24 scientists, we identified four key aspects for fostering societal support for translational efforts in this domain: (1) effective science communication and internal awareness; (2) open societal dialogue; (3) fair and equitable access to new technologies; and (4) adequate science and technology policies. We conclude that molecular systems engineering would benefit from anticipating future challenges with the view of building a robust bond of trust with lay publics, regulators, and society at large.
Publications 1 - 5 of 5