Journal: Haematologica

Abbreviation

Haematologica

Publisher

Fondazione Ferrata Storti

Journal Volumes

ISSN

0390-6078
1592-8721

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Publications 1 - 10 of 13
  • B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow
    Item type: Journal Article
    Barz, Malwine J.; Behrmann, Lena; Capron, Danaëlle; et al. (2023)
    Haematologica
    Persistence of residual disease after induction chemotherapy is a strong predictor of relapse in acute lymphoblastic leukemia (ALL). The bone marrow microenvironment may support escape from treatment. Using three-dimensional fluorescence imaging of ten primary ALL xenografts we identified sites of predilection in the bone marrow for resistance to induction with dexamethasone, vincristine and doxorubicin. We detected B-cell precursor ALL cells predominantly in the perisinusoidal space at early engraftment and after chemotherapy. The spatial distribution of T-ALL cells was more widespread with contacts to endosteum, nestin+ pericytes and sinusoids. Dispersion of T-ALL cells in the bone marrow increased under chemotherapeutic pressure. A subset of slowly dividing ALL cells was transiently detected upon short-term chemotherapy, but not at residual disease after chemotherapy, challenging the notion that ALL cells escape treatment by direct induction of a dormant state in the niche. These lineage-dependent differences point to niche interactions that may be more specifically exploitable to improve treatment.
  • How complement amplification can be stimulated at the onset of a systemic inflammatory response in sepsis
    Item type: Other Conference Item
    Lutz, Hans U.; Fumiax, Sandra; Goede, Jeroen S.; et al. (2008)
    Haematologica
  • Gene expression profiles and risk stratification in childhood acute lymphoblastic leukemia
    Item type: Journal Article
    Teuffel, Oliver; Dettling, Marcel; Cario, Gunnar; et al. (2004)
    Haematologica
  • The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women
    Item type: Journal Article
    Stoffel, Nicole U.; Lazrak, Meryem; Bellitir, Souhaila; et al. (2019)
    Haematologica
    Hepatic hepcidin synthesis is stimulated by inflammation but inhibited during iron deficiency anemia (IDA). In humans, the relative strength of these opposing signals on serum hepcidin and the net effect on iron absorption and systemic iron recycling is uncertain. In this prospective, 45-day study, in young women (n=46; age 18-49 years) with or without IDA, we compared iron and inflammation markers, serum hepcidin and erythrocyte iron incorporation from 57Fe-labeled test meals, before and 8, 24 and 36 hours (h) after influenza/DPT vaccination as an acute inflammatory stimulus. Compared to baseline, at 24-36 h after vaccination: 1) interleukin-6 increased 2-3-fold in both groups (P<0.001); 2) serum hepcidin increased >2-fold in the non-anemic group (P<0.001), but did not significantly change in the IDA group; 3) serum iron decreased in the non-anemic group (P<0.05) but did not change in the IDA group; and 4) erythrocyte iron incorporation did not change in either of the two groups, but was approximately 2-fold higher in the IDA group both before and after vaccination (P<0.001). In this study, mild acute inflammation did not increase serum hepcidin in women with IDA, suggesting low iron status and erythropoietic drive offset the inflammatory stimulus on hepcidin expression. In non-anemic women, inflammation increased serum hepcidin and produced mild hypoferremia, but did not reduce dietary iron absorption, suggesting iron-recycling macrophages are more sensitive than the enterocyte to high serum hepcidin during inflammation. The study was registered as a prospective observational trial at clinicaltrials.gov identifier: 02175888. The study was funded by the International Atomic Energy Agency.
  • Cryohydrocytosis: Increased activity of cation carriers in red cells from a patient with a band 3 mutation
    Item type: Journal Article
    Bogdanova, Anna; Goede, Jeroen S.; Weiss, Erwin; et al. (2009)
    Haematologica
  • Persistence of recipient-type endothelium after allogeneic hematopoietic stem cell transplantation
    Item type: Journal Article
    Mueller, Regula J.; Stussi, Georg; Yung, Gisella Puga; et al. (2011)
    Haematologica
  • Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women
    Item type: Journal Article
    Stoffel, Nicole U.; Zeder, Christophe; Brittenham, Gary M.; et al. (2020)
    Haematologica
  • The TMPRSS6 variant (SNP rs855791) affects iron metabolism and oral iron absorption – a stable iron isotope study in Taiwanese women
    Item type: Journal Article
    Buerkli, Simone; Pei, Sung-Nan; Hsiao, Shu-Chen; et al. (2021)
    Haematologica
    Genome wide studies have associated TMPRSS6 rs855791 (2321 C>T) with iron status and hepcidin. It is unclear whether this polymorphism affects iron absorption. In nonanemic Taiwanese women (n=79, 44 TT variant, 35 CC variant), we administered standardized rice-based test meals containing 4 mg of labeled 57Fe or 58Fe as FeSO4 on alternate days. Fractional iron absorption was measured by erythrocyte incorporation of the tracers 14 days after administration. Compared to the CC variant, in the TT variant serum iron and transferrin saturation were lower (P=0.001; P<0.001, respectively) and serum hepcidin/transferrin saturation and serum hepcidin/serum iron ratios were higher (P=0.042; P=0.088, respectively). Serum hepcidin did not differ between groups (P=0.862). Geometric mean (95% CI) fractional iron absorption, corrected to a serum ferritin of 15 g/L, was 26.6% (24.0, 29.5) in the CC variant and 18.5% (16.2, 21.1) in the TT variant (P=0.002). Overall, predictors of iron absorption were: serum ferritin (P<0.001); genetic variant (P=0.032); and hepcidin (P<0.001). In the models by variant, in the CC variant the model explained 67-71% of variability in absorption and serum ferritin was the only significant predictor (P<0.001); in the TT variant, the model explained only 35-43% of variability, and hemoglobin (P=0.032), soluble transferrin receptor (P=0.004) and hepcidin (P<0.001) were significant predictors. Women with the TMPRSS6 rs855791 (2321 C>T) polymorphism show altered iron homeostasis which affects oral iron absorption and may increase their risk for iron deficiency. The trial was registered at www.clinicaltrials.gov as NCT03317873, and funded by the Kaohsiung Chang-Gung Memorial Hospital, Kaohsiung, Taiwan, (grant CMRPG8F0721) and ETH Zurich, Switzerland.
  • Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbb^th3/+ (heterozygous b1/b2 globin gene deletion) mice
    Item type: Journal Article
    Gelderman, Monique P.; Baek, Jin Hyen; Yalamanoglu, Ayla; et al. (2015)
    Haematologica
Publications 1 - 10 of 13