Journal of Controlled Release

Journal: Journal of Controlled Release

Abbreviation

J. control. release

Publisher

Elsevier

ISSN

0168-3659
1873-4995

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Publications 1 - 10 of 91

Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity
Ehrbar, Martin; Metters, Andrew; Zammaretti, Prisca; et al. (2005)
Journal of Controlled Release
New approaches to delivering metal-labeled antibodies to tumors: Synthesis and characterization of new biotinyl chelate conjugates for pre-targeted diagnosis and therapy
Renn, Oliver; Goodwin, David A.; Studer, Martin; et al. (1996)
Journal of Controlled Release ~ Advances in drug delivery systems, 7 : proceedings of the Seventh International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, USA, February 27-March 2, 1995
New pharmaceutical applications for macromolecular binders
Bertrand, Nicolas; Gauthier, Marc A.; Bouvet, Céline; et al. (2011)
Journal of Controlled Release
Twin disulfides as opportunity for improving stability and transfection efficiency of oligoaminoethane polyplexes
Klein, Philipp M.; Müller, Katharina; Gutmann, Christina; et al. (2015)
Journal of Controlled Release
A non-internalizing antibody-drug conjugate based on an anthracycline payload displays potent therapeutic activity in vivo
Dal Corso, Alberto; Gébleux, Rémy; Murer, Patrizia; et al. (2017)
Journal of Controlled Release
Silk fibroin spheres as a platform for controlled drug delivery
Wenk, Esther; Wandrey, Anne J.; Merkle, Hans P.; et al. (2008)
Journal of Controlled Release
Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells
Uebersax, Lorenz; Merkle, Hans P.; Meinel, Lorenz (2008)
Journal of Controlled Release
Silk fibroin as a vehicle for drug delivery applications
Wenk, Esther; Merkle, Hans P.; Meinel, Lorenz (2011)
Journal of Controlled Release
Liposome-supported peritoneal dialysis in the treatment of severe hyperammonemia: An investigation on potential interactions
Giacalone, Giovanna; Matoori, Simon; Agostoni, Valentina; et al. (2018)
Journal of Controlled Release
Peritoneal dialysis (PD) performed with transmembrane pH-gradient liposomes was reported to efficiently remove ammonia from the body, representing a promising alternative to current standard-of-care for patients with severe hepatic encephalopathy. In this study, we further characterized the properties of liposome-supported peritoneal dialysis (LSPD) by 1) assessing its in-use stability in the presence of ascitic fluids from liver-disease patients; 2) investigating its interactions with drugs that are commonly administered to acute-on-chronic liver failure patients; and 3) analyzing the in vivo extraction profile of LSPD. We found that LSPD fluid maintained its in vitro ammonia uptake capability when combined with ascitic fluids. The co-incubation of selected drugs (e.g., beta-blockers, antibiotics, diuretics) with LSPD fluids and ammonia resulted in limited interaction effects for most compounds except for two fluoroquinolones and propranolol. However, considering the experimental set-up, these results should be interpreted with caution and confirmatory drug-drug interaction studies in a clinical setting will be required. Finally, metabolite-mapping analysis on dialysates of LSPD-treated rats revealed that the liposomes did not remove important metabolites more than a conventional PD fluid. Overall, these findings confirm that LSPD is a potentially safe and effective approach for treating hyperammonemic crises in the context of acute-on-chronic liver failure.
Collagen nerve conduits releasing the neurotrophic factors GDNF and NGF
Madduri, Srinivas; Feldman, Kirill; Tervoort, Theo A.; et al. (2010)
Journal of Controlled Release

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