The Journal of Physiology

Journal: The Journal of Physiology

Abbreviation

J Physiol

Publisher

Wiley-Blackwell

ISSN

0022-3751
1469-7793

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Publications 1 - 10 of 23

Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training
Montero, David; Cathomen, Adrian; Jacobs, Robert A.; et al. (2015)
The Journal of Physiology
Multiple mechanisms govern the dynamics of depression at neocortical synapses of young rats
Fuhrmann, Galit; Cowan, Anna; Segev, Idan; et al. (2004)
The Journal of Physiology
Cardiac system bioenergetics: metabolic basis of the Frank-Starling law
Saks, Valdur; Dzeja, Petras; Schlattner, Uwe; et al. (2006)
The Journal of Physiology
The fundamental principle of cardiac behaviour is described by the Frank-Starling law relating force of contraction during systole with end-diastolic volume. While both work and respiration rates increase linearly with imposed load, the basis of mechano-energetic coupling in heart muscle has remained a long-standing enigma. Here, we highlight advances made in understanding of complex cellular and molecular mechanisms that orchestrate coupling of mitochondrial oxidative phosphorylation with ATP utilization for muscle contraction. Cardiac system bioenergetics critically depends on an interrelated metabolic infrastructure regulating mitochondrial respiration and energy fluxes throughout cellular compartments. The data reviewed indicate the significance of two interrelated systems regulating mitochondrial respiration and energy fluxes in cells: (1) the creatine kinase, adenylate kinase and glycolytic pathways that communicate flux changes generated by cellular ATPases within structurally organized enzymatic modules and networks; and (2) a secondary system based on mitochondrial participation in cellular calcium cycle, which adjusts substrate oxidation and energy-transducing processes to meet increasing cellular energy demands. By conveying energetic signals to metabolic sensors, coupled phosphotransfer reactions provide a high-fidelity regulation of the excitation–contraction cycle. Such integration of energetics with calcium signalling systems provides the basis for ‘metabolic pacing’, synchronizing the cellular electrical and mechanical activities with energy supply processes.
Molecular system bioenergetics
Saks, Valdur; Favier, Roland; Guzun, Rita; et al. (2006)
The Journal of Physiology
Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans
De Bock, Katrien; Richter, E.A.; Russell, A.P.; et al. (2005)
The Journal of Physiology
Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humans
Amann, Markus; Proctor, Lester T.; Sebranek, Joshua J.; et al. (2009)
The Journal of Physiology
Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?
Merry, Troy L.; Ristow, Michael (2016)
The Journal of Physiology
A novel fat connection from gut to brain
Langhans, Wolfgang (2015)
The Journal of Physiology
Endocannabinoid-dependent plasticity at spinal nociceptor synapses
Kato, Ako; Punnakkal, Pradeep; Pernía-Andrade, Alejandro Javier; et al. (2012)
The Journal of Physiology
Sarcomere popping requires stretch over a range where total tension decreases with length
Telley, I.A.; Stussi, E.; Denoth, J.; et al. (2006)
The Journal of Physiology

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