Journal: The Journal of Physiology
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Abbreviation
J Physiol
Publisher
Wiley-Blackwell
23 results
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Publications 1 - 10 of 23
- Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance trainingItem type: Journal Article
The Journal of PhysiologyMontero, David; Cathomen, Adrian; Jacobs, Robert A.; et al. (2015) - Multiple mechanisms govern the dynamics of depression at neocortical synapses of young ratsItem type: Journal Article
The Journal of PhysiologyFuhrmann, Galit; Cowan, Anna; Segev, Idan; et al. (2004) - Cardiac system bioenergetics: metabolic basis of the Frank-Starling lawItem type: Journal Article
The Journal of PhysiologySaks, Valdur; Dzeja, Petras; Schlattner, Uwe; et al. (2006)The fundamental principle of cardiac behaviour is described by the Frank-Starling law relating force of contraction during systole with end-diastolic volume. While both work and respiration rates increase linearly with imposed load, the basis of mechano-energetic coupling in heart muscle has remained a long-standing enigma. Here, we highlight advances made in understanding of complex cellular and molecular mechanisms that orchestrate coupling of mitochondrial oxidative phosphorylation with ATP utilization for muscle contraction. Cardiac system bioenergetics critically depends on an interrelated metabolic infrastructure regulating mitochondrial respiration and energy fluxes throughout cellular compartments. The data reviewed indicate the significance of two interrelated systems regulating mitochondrial respiration and energy fluxes in cells: (1) the creatine kinase, adenylate kinase and glycolytic pathways that communicate flux changes generated by cellular ATPases within structurally organized enzymatic modules and networks; and (2) a secondary system based on mitochondrial participation in cellular calcium cycle, which adjusts substrate oxidation and energy-transducing processes to meet increasing cellular energy demands. By conveying energetic signals to metabolic sensors, coupled phosphotransfer reactions provide a high-fidelity regulation of the excitation–contraction cycle. Such integration of energetics with calcium signalling systems provides the basis for ‘metabolic pacing’, synchronizing the cellular electrical and mechanical activities with energy supply processes. - Molecular system bioenergeticsItem type: Journal Article
The Journal of PhysiologySaks, Valdur; Favier, Roland; Guzun, Rita; et al. (2006) - Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humansItem type: Journal Article
The Journal of PhysiologyDe Bock, Katrien; Richter, E.A.; Russell, A.P.; et al. (2005) - Opioid-mediated muscle afferents inhibit central motor drive and limit peripheral muscle fatigue development in humansItem type: Journal Article
The Journal of PhysiologyAmann, Markus; Proctor, Lester T.; Sebranek, Joshua J.; et al. (2009) - Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?Item type: Journal Article
The Journal of PhysiologyMerry, Troy L.; Ristow, Michael (2016) - A novel fat connection from gut to brainItem type: Journal Article
The Journal of PhysiologyLanghans, Wolfgang (2015) - Endocannabinoid-dependent plasticity at spinal nociceptor synapsesItem type: Journal Article
The Journal of PhysiologyKato, Ako; Punnakkal, Pradeep; Pernía-Andrade, Alejandro Javier; et al. (2012) - Sarcomere popping requires stretch over a range where total tension decreases with lengthItem type: Other Journal Item
The Journal of PhysiologyTelley, I.A.; Stussi, E.; Denoth, J.; et al. (2006)
Publications 1 - 10 of 23