Journal: Frontiers in Bioscience

Abbreviation

Front. biosci.

Publisher

Frontiers in Bioscience

Journal Volumes

ISSN

1093-9946
1093-4715

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2008 - 200922010 - 20183
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Publications 1 - 5 of 5
  • Discrete, qualitative models of interaction networks
    Item type: Review Article
    Ballerstein, Kathrin; Haus, Utz-Uwe; Lindquist, Jonathan Axel; et al. (2013)
    Frontiers in Bioscience
    Logical models for cellular signaling networks are recently attracting wide interest: Their ability to integrate qualitative information at different biological levels, from receptor-ligand interactions to gene-regulatory networks, is becoming essential for understanding complex signaling behavior. We present an overview of Boolean modeling paradigms and discuss in detail an approach based on causal logical interactions that yields descriptive and predictive signaling network models. Our approach offers a mathematically well-defined concept, improving the efficiency of analytical tools to meet the demand of large-scale data sets, and can be extended into various directions to include timing information as well as multiple discrete values for components.
  • Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio
    Item type: Journal Article
    Modica, Salvatore; Bellafante, Elena; Moschetta, Antonio (2009)
    Frontiers in Bioscience
    Recent discoveries highlighted intriguing molecular pathways that regulate synthesis, uptake, metabolism and excretion of bile acids and xenobiotics. The knowledge of factors that control these homeostatic processes is of clinical relevance to better understand the drug-drug interacting scenario as well as to control cholesterol detoxification, cholestasis and other conditions. Here we present evidences for the existence of a gut-liver safety network whereby activation of the nuclear receptor FXR, PXR, CAR trio provides protection against accumulation of exogenous and metabolic noxae.
  • CD proteome and beyond - technologies for targeting the immune cell surfaceome
    Item type: Review Article
    Bock, Thomas; Bausch-Fluck, Damaris; Hofmann, Andreas; et al. (2012)
    Frontiers in Bioscience
    Communication between cells of the immune system and the organism is dependent on information processing mediated by proteins of the cell surface. The cell surface proteome consists of a group of functionally diverse proteins, which not only enables but also limits the interaction capacities of cells within their particular microenvironment. Although these proteins represent a highly important proteome for immunological research, most routinely used technologies for their detection only allow for a fragmented view of the ensemble of cell surface located proteins. A major bottleneck is the limited availability of high quality antibodies against cell surface protein targets that altogether impedes a Systems Biology view on the cell surface proteome (surfaceome) and its concerted functions during signal processing. Recent developments in mass spectrometry-based technologies enable now complementary approaches for the qualitative and quantitative analysis of the surfaceome. Here, we highlight recent progress in the field towards the identification and quantification of the surfaceome as an important subproteome forming the information gateway of the cell.
  • EEG and ERP biomarkers of Alzheimer's disease: a critical review
    Item type: Review Article
    Horvath, Andras; Szucs, Anna; Csukly, Gábor; et al. (2018)
    Frontiers in Bioscience
    Here we critically review studies that used electroencephalography (EEG) or event-related potential (ERP) indices as a biomarker of Alzheimer’s disease. In the first part we overview studies that relied on visual inspection of EEG traces and spectral characteristics of EEG. Second, we survey analysis methods motivated by dynamical systems theory (DST) as well as more recent network connectivity approaches. In the third part we review studies of sleep. Next, we compare the utility of early and late ERP components in dementia research. In the section on mismatch negativity (MMN) studies we summarize their results and limitations and outline the emerging field of computational neurology. In the following we overview the use of EEG in the differential diagnosis of the most common neurocognitive disorders. Finally, we provide a summary of the state of the field and conclude that several promising EEG/ERP indices of synaptic neurotransmission are worth considering as potential biomarkers. Furthermore, we highlight some practical issues and discuss future challenges as well.
  • The optokinetic response in zebrafish and its applications
    Item type: Journal Article
    Huang, Ying-Yu; Neuhauss, Stephan C. F. (2008)
    Frontiers in Bioscience
    The optokinetic response (OKR) is a stereotyped eye movement in response to movement in he surround. The OKR serves to stabilize the visual image on the retina, and allows for high resolution vision. Due to its high selection value, all vertebrates display this basic behavior. Here, we review the properties of the OKR with a focus on the zebrafish, including methodological aspects of measuring eye movements in small larvae. The genetic amenabilities of the zebrafish model permit the use of this reflexive behavior in genetic screens. Such approaches have led to the isolation of mutant strains with specific defects in the visual pathway. In addition to the use of the OKR as a screening assay, mutations with characteristic abnormalities in the execution of this behavior will enable the analysis of sensory-motor control in great detail. A case in point is the belladonna mutation, where an axonal misrouting effect at the optic chiasm leads to a reversed OKR with a number of interesting properties.
Publications 1 - 5 of 5