Investigative Radiology

Journal: Investigative Radiology

Abbreviation

Invest. Radiol.

Publisher

Lippincott Williams & Wilkins

ISSN

0020-9996
1536-0210

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Publications 1 - 10 of 29

Magnetic Resonance Imaging of the Temporomandibular Joint at 7.0 T Using High-Permittivity Dielectric Pads A Feasibility Study
Manoliu, Andrei; Spinner, Georg; Wyss, Michael; et al. (2015)
Investigative Radiology
T1- and T2*-Mapping for Assessment of Tendon Tissue Biophysical Properties: a Phantom MRI Study
Bachmann, Elias; Rosskopf, Andrea B.; Götschi, Tobias; et al. (2018)
Investigative Radiology
3D Fusion of Functional Cardiac Magnetic Resonance Imaging and Computed Tomography Coronary Angiography
Donati, Olivio F.; Alkadhi, Hatem; Scheffel, Hans; et al. (2011)
Investigative Radiology
Perfluorocarbon Compound aerosols for Delivery to the Lung as Potential F-19 NMR Reporters of Regional Pulmonary pO2
Thomas, Stephen R.; Gradon, Leon; Pratsinis, Sotiris E.; et al. (1997)
Investigative Radiology
A Randomized Trial of Intra-articular Injection Therapy for Knee Osteoarthritis
Tschopp, Marcel; Pfirrmann, Christian W.A.; Fucentese, Sandro F.; et al. (2023)
Investigative Radiology
Background Intra-articular injections are widely used for conservative treatment of knee osteoarthritis (OA). However, rigorous data are lacking regarding the comparative therapeutic effectiveness of these injections.Purpose The aim of this study was to compare clinical outcomes after intra-articular injections of glucocorticoid, hyaluronic acid, platelet-rich plasma (PRP), or placebo in patients with mild or moderate OA of the knee.Materials and Methods In a double-blinded, placebo-controlled, single-center trial, we randomly assigned knees with early- to middle-stage knee OA (Kellgren-Lawrence grade 1-3) to an intra-articular injection with one of these substances: glucocorticoid, hyaluronic acid, PRP, or placebo. Primary outcome was pain reduction within 6 months after the injection, assessed with the numeric rating scale (NRS; range, 0-100). Secondary outcome parameters included WOMAC scores, Tegner Activity Scale, knee mobility, and adverse events. Finally, a linear mixed-effects model was calculated and corrected for possible patient and covariate effects.Results One hundred twenty knees (30 knees per treatment group) in 95 patients (41 female) were included in the final analysis. The median age of patients was 60 years (interquartile range, 54.0-68.0). There was no evidence that the drug effects of primary and secondary outcome parameters differed over time. The median pain at baseline was 32.5 (interquartile range, 15.00-50.00) on NRS. The changes in pain level during the first 6 months compared with baseline were small (within +/- 5 points on NRS), whereas the intrapatient variability was large between -20 and +20 points. Secondary outcome parameters did not differ significantly among the groups. Kellgren-Lawrence grade did not have a statistically significant effect on pain reduction (P = 0.61).Conclusions There is no evidence that knee injections with glucocorticoid, PRP, or hyaluronic acid have superior short- or long-term effects in patients with low pain level at baseline and early- to middle-stage knee OA when compared with placebo.
Quantification of Avoidable Radiation Exposure in Interventional Fluoroscopy With Eye Tracking Technology
Zimmermann, Jan Michael; Vicentini, Luca; Van Story, David; et al. (2020)
Investigative Radiology
A study on mastectomy samples to evaluate breast imaging quality and potential clinical relevance of differential phase contrast mammography
Hauser, Nik; Wang, Z.; Kubik-Huch, R.A.; et al. (2014)
Investigative Radiology
Feasibility of k-t BLAST for BOLD fMRI with a spin-echo based acquisition at 3 T and 7 T
Utting, Jane F.; Kozerke, Sebastian; Luechinger, Roger; et al. (2009)
Investigative Radiology
T2* Mapping of Articular Cartilage: Current Status of Research and First Clinical Applications
Andreisek, Gustav; Weiger, Markus (2014)
Investigative Radiology
T2* mapping is a relatively new method for the compositional assessment of the articular cartilage. Typically, a multigradient echo or an ultrashort echo time imaging technique with a range of short and very short echo times is used. In most studies, imaging is performed at a high field strength, that is, 3 and 7 T. Postprocessing includes exponential fitting of relaxation decay and manual region-of-interest–based measurements of T2* times on T2* maps. Detailed analyses of T2* times of articular cartilage have shown distinct T2* components with shorter and longer T2* times. Moreover, there is a zonal distribution with a significant depthwise gradient of T2*, with relatively short times near the osteochondral junction and relatively long times at the cartilage’s surface. T2* times of normal articular cartilage at the knee are, when averaged over the whole cartilage thickness and using monoexponential fitting, approximately 20 milliseconds. The results of recent studies have shown a good test-retest as well as interreader and intrareader reliabilities for T2* mapping. This article provides a descriptive review of the current literature, briefly discusses the technique itself, and provides an outlook on future research questions and possible clinical applications.
Free-Breathing Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging in a Rat Liver Tumor Model Using Dynamic Radial T1 Mapping
Braren, Rickmer; Curcic, Jelena; Remmele, Stefanie; et al. (2011)
Investigative Radiology

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