Nature Reviews Genetics

Journal: Nature Reviews Genetics

Abbreviation

Nat Rev Genet

Publisher

Nature

ISSN

1471-0056
1471-0064

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Publications 1 - 10 of 13

The lives of cells, recorded
Askary, Amjad; Chen, Wei; Choi, Junhong; et al. (2025)
Nature Reviews Genetics
A paradigm for biology is emerging in which cells can be genetically programmed to write their histories into their own genomes. These records can subsequently be read, and the cellular histories reconstructed, which for each cell could include a record of its lineage relationships, extrinsic influences, internal states and physical locations, over time. DNA recording has the potential to transform the way that we study developmental and disease processes. Recent advances in genome engineering are driving the development of systems for DNA recording, and meanwhile single-cell and spatial omics technologies increasingly enable the recovery of the recorded information. Combined with advances in computational and phylogenetic inference algorithms, the DNA recording paradigm is beginning to bear fruit. In this Perspective, we explore the rationale and technical basis of DNA recording, what aspects of cellular biology might be recorded and how, and the types of discovery that we anticipate this paradigm will enable.
Molecular insights into transgenerational non-genetic inheritance of acquired behaviours
Bohacek, Johannes; Mansuy, Isabelle (2015)
Nature Reviews Genetics
Applying mass spectrometry-based proteomics to genetics, genomics and network biology
Gstaiger, Matthias; Aebersold, Ruedi (2009)
Nature Reviews Genetics
Silencing chromatin
Beisel, Christian; Paro, Renato (2011)
Nature Reviews Genetics
The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts
MacLean, R. Craig; Hall, Alex R.; Perron, Gabriel G.; et al. (2010)
Nature Reviews Genetics
Biomolecular computing systems: principles, progress and potential
Benenson, Yaakov (2012)
Nature Reviews Genetics
Opinion: Unravelling the general properties of siRNAs: strength in numbers and lessons from the past
Hall, Jonathan (2004)
Nature Reviews Genetics
Emerging biomedical applications of synthetic biology
Weber, Wilfried; Fussenegger, Martin (2012)
Nature Reviews Genetics
Detecting genetic responses to environmental change
Hoffmann, Ary A.; Willi, Yvonne (2008)
Nature Reviews Genetics
The causes of evolvability and their evolution
Payne, Joshua L.; Wagner, Andreas (2018)
Nature Reviews Genetics

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