Structure

Journal: Structure

Publisher

Cell Press

ISSN

0969-2126
1878-4186

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Publications 1 - 10 of 65

A novel strategy for inhibition of alpha-amylases: yellow meal worm alpha-amylase in complex with the Ragi bifunctional inhibitor at 2.5 A resolution
Strobl, Stefan; Maskos, Klaus; Wiegand, Georg; et al. (1998)
Structure
Beyond Induced-Fit Receptor-Ligand Interactions: Structural Changes that Can Significantly Extend Bond Lifetimes
Nilsson, Lina M.; Thomas, Wendy E.; Sokurenko, Evgeni V.; et al. (2008)
Structure
The Dynamic Basis for Signal Propagation in Human Pin1-WW
Olsson, Simon; Strotz, Dean; Vögeli, Beat; et al. (2016)
Structure
A2A adenosine receptor partial agonism related to structural rearrangements in an activation microswitch
Eddy, Matthew T.; Martin, Bryan T.; Wüthrich, Kurt (2021)
Structure
In drug design, G protein-coupled receptor (GPCR) partial agonists enable one to fine-tune receptor output between basal and maximal signaling levels. Here, we add to the structural basis for rationalizing and monitoring partial agonism. NMR spectroscopy of partial agonist complexes of the A2A adenosine receptor (A2AAR) revealed conformations of the P-I-F activation motif that are distinctly different from full agonist complexes. At the intracellular surface, different conformations of helix VI observed for partial and full agonist complexes manifest a correlation between the efficacy-related structural rearrangement of this activation motif and intracellular signaling to partner proteins. While comparisons of A2AAR in complexes with partial and full agonists with different methods showed close similarity of the global folds, this NMR study now reveals subtle but distinct local structural differences related to partial agonism.
Dynamic local polymorphisms in the Gbx1 homeodomain induced by DNA binding
Proudfoot, Andrew; Geralt, Michael; Elsliger, Marc-André; et al. (2016)
Structure
Mechanistic Explanation of Different Unfolding Behaviors Observed for Transmembrane and Soluble β-Barrel Proteins
Hensen, Ulf; Müller, Daniel J. (2013)
Structure
Structural Analysis of the Bacterial Proteasome Activator Bpa in Complex with the 20S Proteasome
Bolten, Marcel; Delley, Cyrille L.; Leibundgut, Marc; et al. (2016)
Structure
Probing the Interactions of Carboxy-atractyloside and Atractyloside with the Yeast Mitochondrial ADP/ATP Carrier
Kedrov, Alexej; Hellawell, Alex M.; Klosin, Adam; et al. (2010)
Structure
POTRA Domains, Extracellular Lid, and Membrane Composition Modulate the Conformational Stability of the β Barrel Assembly Factor BamA
Thoma, Johannes; Sun, Yang; Ritzmann, Noah; et al. (2018)
Structure
Predictive Atomic Resolution Descriptions of Intrinsically Disordered hTau40 and α-Synuclein in Solution from NMR and Small Angle Scattering
Schwalbe, Martin; Ozenne, Valéry; Bibow, Stefan; et al. (2013)
Structure

Publications 1 - 10 of 65

Journal: Structure

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