Journal: Applied Physiology, Nutrition, and Metabolism

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Canadian Science Publishing

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ISSN

1715-5312
1715-5320

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2016 - 201912020 - 20222
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Publications 1 - 3 of 3
  • Passive leg cycling increases activity of the cardiorespiratory system in people with tetraplegia
    Item type: Journal Article
    Soriano, Jan Elaine; Romac, Rinaldo; Squair, Jordan W.; et al. (2022)
    Applied Physiology, Nutrition, and Metabolism
    Individuals with cervical spinal cord injury (SCI) are at an increased risk for cardiovascular disease. Exercise is well-established for preventing cardiovascular disease; however, there are limited straightforward and safe exercise approaches for increasing the activity of the cardiorespiratory system after cervical SCI. The objective of this study was to investigate the cardiorespiratory response to passive leg cycling in people with cervical SCI. Beat-by-beat blood pressure, heart rate, and cerebral blood flow were measured before and throughout 10 minutes of cycling in 11 people with SCI. Femoral artery flow-mediated dilation was also assessed before and immediately after passive cycling. Safety was monitored throughout all study visits. Passive cycling elevated systolic blood pressure (5 ± 2 mm Hg), mean arterial pressure (5 ± 3 mm Hg), stroke volume (2.4 ± 0.8 mL), heart rate (2 ± 1 beats/min) and cardiac output (0.3 ± 0.07 L/min; all p < 0.05). Minute ventilation (0.67 ± 0.23 L/min), tidal volume (70 ± 30 mL) and end-tidal PO2 (2.6 ± 1.23 mm Hg) also increased (all p < 0.05). Endothelial function was improved immediately after exercise (1.62 ± 0.13%, p < 0.01). Passive cycling resulted in an incidence of autonomic dysreflexia. Therefore, passive leg cycling increased the activity of the cardiorespiratory system and improved endothelial function, indicating it may be a beneficial exercise intervention for the cardiovascular and respiratory systems in people with cervical SCI.
  • Is beetroot juice more effective than sodium nitrate? The effects of equimolar nitrate dosages of nitrate-rich beetroot juice and sodium nitrate on oxygen consumption during exercise
    Item type: Journal Article
    Flück, Joëlle Leonie; Bogdanova, Anna; Mettler, Samuel; et al. (2016)
    Applied Physiology, Nutrition, and Metabolism
  • Reliability of diaphragm voluntary activation measurements in healthy adults
    Item type: Journal Article
    Ramsook, Andrew H.; Molgat-Seon, Yannick; Boyle, Kyle G.; et al. (2021)
    Applied Physiology, Nutrition, and Metabolism
    Voluntary activation can be used to assess central fatigue of the diaphragm after tasks such as exercise or inspiratory muscle loading. Cervical magnetic stimulation (CMS) of the phrenic nerves elicits an involuntary contraction, or twitch of the diaphragm. This twitch is quantified based on a measure of transdiaphragmatic pressure (Pdi) and can be used to evaluate diaphragm contractile function and diaphragm voluntary activation (diaphragm-VA). The test-retest reliability of diaphragm-VA using CMS is currently unknown. Thirteen participants (4M:9F; 25±3 years) performed a series of interpolated twitch manoeuvres, which included a maximal inspiratory effort against a semi-occluded mouthpiece and two CMS-stimuli, one during the inspiratory manoeuvre and one after when the participant returned to functional residual capacity to quantify diaphragm-VA. Intraclass correlation coefficients (ICC) and standard error of measurement (SEM) measured between-day and within-session reliability of diaphragm-VA, respectively. Maximal diaphragm-VA values were 90±8% (SEM: 3.8%) and 91±7% (SEM: 3.8%) during visits 1 and 2 (p=0.781), respectively, and displayed ‘excellent’ between-day reliability (ICC:0.98; 95%CI:0.96-1.00; SEM: 1.5%). Our results suggest that assessing diaphragm-VA using CMS is reliable in young healthy adults. Measuring diaphragm-VA may provide additional insight into the consequences and mechanisms of diaphragm fatigue. Novelty bullets: • Magnetic stimulation of the phrenic nerves can reliably measure voluntary activation of the diaphragm • Diaphragm voluntary activation can be used to provide additional insight into fatigability of the diaphragm.
Publications 1 - 3 of 3