Journal: Neuron

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Cell Press

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0896-6273
1097-4199

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Publications 1 - 10 of 50
  • The Dynamics of Functional Brain Networks: Integrated Network States during Cognitive Task Performance
    Item type: Journal Article
    Shine, James M.; Bissett, Patrick G.; Bell, Peter T.; et al. (2016)
    Neuron
  • How Diverse Retinal Functions Arise from Feedback at the First Visual Synapse
    Item type: Journal Article
    Drinnenberg, Antonia; Franke, Felix; Morikawa, Rei K.; et al. (2018)
    Neuron
  • Sodium-calcium exchanger-3 regulates pain “wind-up”: From human psychophysics to spinal mechanisms
    Item type: Journal Article
    Trendafilova, Teodora; Kaustubh, Adhikari; Schmid, Annina B.; et al. (2022)
    Neuron
    Repeated application of noxious stimuli leads to a progressively increased pain perception; this temporal summation is enhanced in and predictive of clinical pain disorders. Its electrophysiological correlate is “wind-up,” in which dorsal horn spinal neurons increase their response to repeated nociceptor stimulation. To understand the genetic basis of temporal summation, we undertook a GWAS of wind-up in healthy human volunteers and found significant association with SLC8A3 encoding sodium-calcium exchanger type 3 (NCX3). NCX3 was expressed in mouse dorsal horn neurons, and mice lacking NCX3 showed normal, acute pain but hypersensitivity to the second phase of the formalin test and chronic constriction injury. Dorsal horn neurons lacking NCX3 showed increased intracellular calcium following repetitive stimulation, slowed calcium clearance, and increased wind-up. Moreover, virally mediated enhanced spinal expression of NCX3 reduced central sensitization. Our study highlights Ca2+ efflux as a pathway underlying temporal summation and persistent pain, which may be amenable to therapeutic targeting.
  • An essential switch in subunit composition of a chromatin remodeling complex during neural development
    Item type: Journal Article
    Lessard, Julie; Wu, Jiang I.; Ranish, Jeffrey A.; et al. (2007)
    Neuron
  • Reflections
    Item type: Journal Article
    Schwab, Martin E.; Caroni, Pico (2008)
    Neuron
  • Hair Bundles Are Specialized for ATP Delivery via Creatine Kinase
    Item type: Journal Article
    Shin, Jung-Bum; Streijger, Femke; Beynon, Andy; et al. (2007)
    Neuron
  • Lights, fiber, action! A primer on in vivo fiber photometry
    Item type: Review Article
    Simpson, Eleanor H.; Akam, Thomas; Patriarchi, Tommaso; et al. (2024)
    Neuron
    Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via genetically encoded indicators. This generated new insights into brain functions including movement, memory, and motivation at the level of defined circuits and cell types. Recently, the opportunity for discovery with fiber photometry has exploded with the development of an extensive range of fluorescent sensors for biomolecules including neuromodulators and peptides that were previously inaccessible in vivo. This critical advance, combined with the new availability of affordable “plug-and-play” recording systems, has made monitoring molecules with high spatiotemporal precision during behavior highly accessible. However, while opening exciting new avenues for research, the rapid expansion in fiber photometry applications has occurred without coordination or consensus on best practices. Here, we provide a comprehensive guide to help end-users execute, analyze, and suitably interpret fiber photometry studies.
  • TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
    Item type: Journal Article
    Paolicelli, Rosa C.; Jawaid, Ali; Henstridge, Christopher M.; et al. (2017)
    Neuron
    Microglia coordinate various functions in the central nervous system ranging from removing synaptic connections, to maintaining brain homeostasis by monitoring neuronal function, and clearing protein aggregates across the lifespan. Here we investigated whether increased microglial phagocytic activity that clears amyloid can also cause pathological synapse loss. We identified TDP-43, a DNA-RNA binding protein encoded by the Tardbp gene, as a strong regulator of microglial phagocytosis. Mice lacking TDP-43 in microglia exhibit reduced amyloid load in a model of Alzheimer’s disease (AD) but at the same time display drastic synapse loss, even in the absence of amyloid. Clinical examination from TDP-43 pathology cases reveal a considerably reduced prevalence of AD and decreased amyloid pathology compared to age-matched healthy controls, confirming our experimental results. Overall, our data suggest that dysfunctional microglia might play a causative role in the pathogenesis of neurodegenerative disorders, critically modulating the early stages of cognitive decline.
  • NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory
    Item type: Journal Article
    Saab, Bechara J.; Georgiou, John; Nath, Arup; et al. (2009)
    Neuron
  • Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation
    Item type: Journal Article
    Zerbi, Valerio; Floriou-Servou, Amalia; Markicevic, Marija; et al. (2019)
    Neuron
Publications 1 - 10 of 50