Journal: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology

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Abbreviation

Comp. biochem. physiol., Part A Mol. integr. physiol.

Publisher

Elsevier

Journal Volumes

ISSN

1095-6433
1531-4332

Description

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Publications 1 - 7 of 7
  • Zucchi, S.; Ieronimo, A.; Fent, K. (2010)
    Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
  • Frei, Samuel; Ortmann, Sylvia; Kreuzer, Michael; et al. (2017)
    Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
  • Henry, Youn; Overgaard, Johannes; Colinet, Hervé (2020)
    Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
    The dietary nutrient composition can affect insects' phenotypes by modulating their physiology. Furthermore, diet can affect gut microbiota composition and abundance, with indirect consequences for the host. In this study, we reared Drosophila melanogaster on five different diets; three with balanced sugar:yeast ratio, but with increasing caloric content (2:2, 8:8, 16:16, in weight %), and two with imbalanced sugar:yeast ratio, either with low sugar and high yeast content (2:16) or vice-versa (16:2). In each of these diets, we compared flies with conventional vs. artificially altered gut microbiota with antibiotics that reduced the bacterial load. The antibiotic treatment also had the surprising effect of increasing the amount of live yeast associated with the flies. We characterized flies from these ten treatments (5 dietsx2 microbiota) in terms of development, body mass, food preference, body reserves, metabolic rate and a range of stress tolerance traits (heat, cold, starvation and desiccation tolerance). Diets, and to a lesser extent antibiotic treatment, affected development rate, weight, and cold tolerance of adult flies. Other traits such as energy reserves, metabolic rate, food preference, or starvation tolerance were affected by diet alone. When detected, the effect of antibiotic treatment was stronger in yeast-poor diets, suggesting that gut bacterial community might help to counterbalance nutritional deficiencies. These results show that changes in dietary factors lead to a global re-organization of fly's physiology and development while the manipulation of gut microorganisms had minor effects that were mainly seen in case of protein restriction.
  • Madureira, D.J.; Michaelson, J.; Beyer, A.; et al. (2010)
    Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
  • Herold, Susanna; Fago, Angela (2005)
    Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
    It is now widely accepted that, besides their well-established function in O2 transport, hemoglobin and myoglobin also undergo several redox reactions aimed to scavenge toxic free radicals and reactive oxygen and nitrogen species. At least some of these reactions are believed to play an important physiological role in the defense against oxidative stress. This aspect is exemplified by the recently discovered neuroglobin, a globin expressed in the brain. Rather than being considerably involved in reversible O2 binding, neuroglobin is likely to undergo redox reactions to protect neurons against oxidative and potentially pathogenic pathways, as those operating after episodes of tissue hypoxia or ischemia. A major part of the cellular damage occurring under such conditions has been ascribed to formation of peroxynitrite, that originates from the reaction between two biologically important free radicals, nitric oxide (NO˙) and superoxide. Here we review the current knowledge of the reactions of different forms of hemoglobin, myoglobin, and neuroglobin with peroxynitrite and discuss their physiological role on the basis of measured rate constants and on the probability of occurrence of these reactions in vivo.
  • Clauss, Marcus; Frei, Samuel; Hatt, Jean-Michel; et al. (2020)
    Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
  • Vendl, Catharina; Frei, Samuel; Dittmann, Marie T.; et al. (2016)
    Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology
Publications 1 - 7 of 7