Neuroscience Letters

Journal: Neuroscience Letters

Abbreviation

Neurosci. Lett.

Publisher

Elsevier

ISSN

0304-3940
1872-7972

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Publications1 - 10 of 24

Spinal dis-inhibition in inflammatory pain
Zeilhofer, Hanns U.; Zeilhofer, Ulrike B. (2008)
Neuroscience Letters
Creatine and neurotrophin-4/5 promote survival of nitric oxide synthase-expressing interneurons in striatal cultures
Ducray, Angélique; Kipfer, Stefan; Huber, Alexander W.; et al. (2006)
Neuroscience Letters
Nitric oxide (NO) mediates a variety of physiological functions in the central nervous system and acts as an important developmental regulator. Striatal interneurons expressing neuronal nitric oxide synthase (nNOS) have been described to be relatively spared from the progressive cell loss in Huntington's disease (HD). We have recently shown that creatine, which supports the phosphagen energy system, induces the differentiation of GABAergic cells in cultured striatal tissue. Moreover, neurotrophin-4/5 (NT-4/5) has been found to promote the survival and differentiation of cultured striatal neurons. In the present study, we assessed the effects of creatine and NT-4/5 on nNOS-immunoreactive (-ir) neurons of E14 rat ganglionic eminences grown for 1 week in culture. Chronic administration of creatine [5 mM], NT-4/5 [10 ng/ml], or a combination of both factors significantly increased numbers of nNOS-ir neurons. NT-4/5 exposure also robustly increased levels of nNOS protein. Interestingly, only NT-4/5 and combined treatment significantly increased general viability but no effects were seen for creatine supplementation alone. In addition, NT-4/5 and combined treatment resulted in a significant larger soma size and number of primary neurites of nNOS-ir neurons while creatine administration alone exerted no effects. Double-immunolabeling studies revealed that all nNOS-ir cells co-localized with GABA. In summary, our findings suggest that creatine and NT-4/5 affect differentiation and/or survival of striatal nNOS-ir GABAergic interneurons. These findings provide novel insights into the biology of developing striatal neurons and highlight the potential of both creatine and NT-4/5 as therapeutics for HD.
Potentiation of prelimbic field potentials during and seconds after trains of excitations in the rat hippocampo-prefrontal pathway
Cristoffersen, G.; Petersen, S.; daCosta, N. (2003)
Neuroscience Letters
Engineering embryonic stem cell derived glia for adenosine delivery
Fedele, Denise E.; Koch, Peter; Scheurer, Louis; et al. (2004)
Neuroscience Letters
Cats can detect repeated noise stimuli
Freya, Hans-Peter; Kaernbach, Christian; König, Peter (2003)
Neuroscience Letters
Heat Pain Threshold and Tolerance show no Left-Right Perceptual Differences at Complementary Sites of the Human Forearm
Schaffner, Nils; Wittwer, Amrei; Kut, Elvan; et al. (2008)
Neuroscience Letters
Pain threshold and pain tolerance of heat noxious stimuli were assessed to determine whether they are equivalent when measured at three equidistant sites of both volar forearms. Heat pain threshold and tolerance were measured in 18 healthy volunteers using a standard stimulation device consisting of a thermode. Pain threshold and pain tolerance did not differ within and across forearm sites. Experimenters addressing heat pain threshold and tolerance in healthy volunteers may freely choose and change stimulation sites on both volar forearms, without the risk of confounding site effects on dependent variables. This data completes previous reports on side effects by analyzing the effect of site on the forearm for both heat pain threshold and tolerance. The absence of side and site effects may contribute to setting a more secure basis for assessments of laterality effects of painful stimulation.
Observing shadow motions: resonant activity within the observer's motor system?
Alaerts, Kaat; Aggelpoel, Tinne van; Swinnen, Stephan P.; et al. (2009)
Neuroscience Letters
Enhancement of cell viability after treatment with polyunsaturated fatty acids
Bartl, J.; Walitza, S.; Grünblatt, E. (2014)
Neuroscience Letters
Exogenous application of glucose induces aging in rat cerebral oligodendrocytes as revealed by alteration in telomere length
Dabouras, Vasili; Rothermel, Andrée; Reininger-Mack, Alexandra; et al. (2004)
Neuroscience Letters
A portable and low-cost fMRI compatible pneumatic system for the investigation of the somatosensensory system in clinical and research environments
Wienbruch, Christian; Candia, Victor; Svensson, Jonas; et al. (2006)
Neuroscience Letters

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Journal: Neuroscience Letters

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