Nature Biomedical Engineering

Journal: Nature Biomedical Engineering

Abbreviation

Nat Biomed Eng

Publisher

Springer

ISSN

2157-846X

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Publications1 - 5 of 5

Synthetic gene circuits for the detection, elimination and prevention of disease
Sedlmayer, Ferdinand; Aubel, Dominique; Fussenegger, Martin (2018)
Nature Biomedical Engineering
Engineered allogeneic T cells decoupling T-cell-receptor and CD3 signalling enhance the antitumour activity of bispecific antibodies
Kapetanovic, Edo; Weber, Cédric; Bruand, Marine; et al. (2024)
Nature Biomedical Engineering
Bispecific antibodies (biAbs) used in cancer immunotherapies rely on functional autologous T cells, which are often damaged and depleted in patients with haematological malignancies and in other immunocompromised patients. The adoptive transfer of allogeneic T cells from healthy donors can enhance the efficacy of biAbs, but donor T cells binding to host-cell antigens cause an unwanted alloreactive response. Here we show that allogeneic T cells engineered with a T-cell receptor that does not convert antigen binding into cluster of differentiation 3 (CD3) signalling decouples antigen-mediated T-cell activation from T-cell cytotoxicity while preserving the surface expression of the T-cell-receptor-CD3 signalling complex as well as biAb-mediated CD3 signalling and T-cell activation. In mice with CD19+ tumour xenografts, treatment with the engineered human cells in combination with blinatumomab (a clinically approved biAb) led to the recognition and clearance of tumour cells in the absence of detectable alloreactivity. Our findings support the development of immunotherapies combining biAbs and 'off-the-shelf' allogeneic T cells.
Treatment of chronic pain by designer cells controlled by spearmint aromatherapy
Wang, Hui; Xie, Mingqi; Charpin-El Hamri, Ghislaine; et al. (2018)
Nature Biomedical Engineering
Self-adjusting synthetic gene circuit for correcting insulin resistance
Ye, Haifeng; Xie, Mingqi; Xue, Shuai; et al. (2017)
Nature Biomedical Engineering
A probiotic probe for inflammation
Sedlmayer, Ferdinand; Fussenegger, Martin (2017)
Nature Biomedical Engineering

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Journal: Nature Biomedical Engineering

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