Developmental Biology

Journal: Developmental Biology

Abbreviation

Dev. biol.

Publisher

Elsevier

ISSN

0012-1606
1095-564X

Show all metadata

Search Results

Publications 1 - 10 of 26

Patterning via local cell-cell interactions in developing systems
Boareto do Amaral, Marcelo (2020)
Developmental Biology
Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis
Kaelin, Roland E.; Kretz, Martin P.; Meyer, Andrea M.; et al. (2007)
Developmental Biology
Multiple lineage-specific roles of Smad4 during neural crest development
Büchmann-Møller, Stine; Miescher, Iris; John, Nessy; et al. (2009)
Developmental Biology
The Drosophila larval visual system
Sprecher, Simon G.; Cardona, Albert; Hartenstein, Volker (2011)
Developmental Biology
PDGF-AA interactions with fibronectin reveal a potential role for heparan sulfate in mediating directed cell migration during Xenopus laevis gastrulation
Smith, Erin M.; Mitsi, Maria; Nugent, Matthew A.; et al. (2009)
Developmental Biology
The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulva! development
Morf, Matthias K.; Rimann, Ivo; Alexander, Mariam; et al. (2013)
Developmental Biology
SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development
Almudi, Isabel; Stocker, Hugo; Hafen, Ernst; et al. (2009)
Developmental Biology
Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system
Meysen, Sonia; Marger, Laurine; Hewett, Kenneth W.; et al. (2007)
Developmental Biology
PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditis elegans
Pacquelet, A.; Zanin, E.; Ashiono, C.; et al. (2008)
Developmental Biology
The C. elegans hox gene lin-39 controls cell cycle progression during vulval development
Roiz, Daniel; Escobar-Restrepo, Juan Miguel; Leu, Philipp; et al. (2016)
Developmental Biology
Cell fate specification during organogenesis is usually followed by a phase of cell proliferation to produce the required number of differentiated cells. The Caenorhabditis elegans vulva is an excellent model to study how cell fate specification and cell proliferation are coordinated. The six vulval precursor cells (VPCs) are born at the first larval stage, but they arrest in the G1 phase of the cell cycle until the beginning of the third larval stage, when their fates are specified and the three proximal VPCs proliferate to generate 22 vulval cells. An epidermal growth factor (EGF) signal from the gonadal anchor cell combined with lateral DELTA/NOTCH signaling between the VPCs determine the primary (1°) and secondary (2°) fates, respectively. The hox gene lin-39 plays a key role in integrating these spatial patterning signals and in maintaining the VPCs as polarized epithelial cells. Using a fusion-defective eff-1(lf) mutation to keep the VPCs polarized, we find that VPCs lacking lin-39 can neither activate lateral NOTCH signaling nor proliferate. LIN-39 promotes cell cycle progression through two distinct mechanisms. First, LIN-39 maintains the VPCs competent to proliferate by inducing cdk-4 cdk and cye-1 cyclinE expression via a non-canonical HOX binding motif. Second, LIN-39 activates in the adjacent VPCs the NOTCH signaling pathway, which promotes VPC proliferation independently of LIN-39. The hox gene lin-39 is therefore a central node in a regulatory network coordinating VPC differentiation and proliferation.

Publications 1 - 10 of 26

Journal: Developmental Biology

Abbreviation

Publisher

Journal Volumes

ISSN

Description

Filters

Search Results