The EMBO Journal

Journal: The EMBO Journal

Abbreviation

EMBO J

Publisher

Wiley

ISSN

0261-4189
1460-2075

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Publications 1 - 10 of 51

All-trans retinol, vitamin D and other hydrophobic compounds bind in the axial pore of the five-stranded coiled-coil domain of cartilage oligomeric matrix protein
Guo, Yuan; Bozic, Damir; Malashkevich, Vladimir N.; et al. (1998)
The EMBO Journal
Competing interaction partners modulate the activity of Sgs1 helicase during DNA end resection
Kasaciunaite, Kristina; Fettes, Fergus; Levikova, Maryna; et al. (2019)
The EMBO Journal
The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex
Hassler, Markus; Richmond, Timothy J. (2001)
The EMBO Journal
Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels
Lorenzi, Luca E.; Bah, A.; Wischnewski, H.; et al. (2015)
The EMBO Journal
In situ and high-resolution cryo-EM structure of a bacterial type VI secretion system membrane complex
Rapisarda, Chiara; Cherrak, Yassine; Kooger, Romain; et al. (2019)
The EMBO Journal
Bacteria have evolved macromolecular machineries that secrete effectors and toxins to survive and thrive in diverse environments. The type VI secretion system (T6SS) is a contractile machine that is related to Myoviridae phages. It is composed of a phage tail‐like structure inserted in the bacterial cell envelope by a membrane complex (MC) comprising the TssJ, TssL and TssM proteins. We previously reported the low‐resolution negative‐stain electron microscopy structure of the enteroaggregative Escherichia coli MC and proposed a rotational 5‐fold symmetry with a TssJ:TssL:TssM stoichiometry of 2:2:2. Here, cryo‐electron tomography analyses of the T6SS MC confirm the 5‐fold symmetry in situ and identify the regions of the structure that insert into the bacterial membranes. A high‐resolution model obtained by single‐particle cryo‐electron microscopy highlights new features: five additional copies of TssJ, yielding a TssJ:TssL:TssM stoichiometry of 3:2:2, an 11‐residue loop in TssM, protruding inside the lumen of the MC and constituting a functionally important periplasmic gate, and hinge regions. Based on these data, we propose an updated model on MC structure and dynamics during T6SS assembly and function.
Preferential binding of an unfolded protein to DsbA
Frech, Christian; Wunderlich, Martina; Glockshuber, Rudi; et al. (1996)
The EMBO Journal
Molecular basis of the C-terminal tail-to-tail assembly of the sarcomeric filament protein myomesin
Pinotsis, Nikos; Lange, Stephan; Perriard, Jean-Claude; et al. (2008)
The EMBO Journal
Corrigendum: Differential effects of viral silencing suppressors on siRNA and miRNA loading support the existence of two distinct cellular pools of ARGONAUTE1
Schott, Gregory; Mari-Ordonez, Arturo; Himber, Christophe; et al. (2015)
The EMBO Journal
Genome‐scale, single‐cell‐type resolution of microRNA activities within a whole plant organ
Brosnan, Christopher A.; Sarazin, Alexis; Lim, PeiQi; et al. (2019)
The EMBO Journal
CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk
Hobeika, Elias; Levit-Zerdoun, Ella; Anastasopoulou, Vasiliki; et al. (2015)
The EMBO Journal

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