Planta Medica

Journal: Planta Medica

Abbreviation

Planta med.

Publisher

Thieme

ISSN

0032-0943
1439-0221

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Publications 1 - 10 of 28

Echinacea and its alkamides - an assessment of potential CYP-P450 enzyme inhibition?
Modarai, Maryam; Gertsch, Jürg; Suter, Andy; et al. (2006)
Planta Medica
Natural products - How have they contributed to health and society?
Sticher, Otto (2014)
Planta Medica
Antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin B and a new aryinaphthalide lignan from Phyllanthus piscatorum
Gertsch, Jürg; Thöni Tobler, Rebekka; Brun, Reto; et al. (2003)
Planta Medica
New cytotoxic prenylated isoflavonoids from Bituminaria morisiana
Cottiglia, F.; Casu, L.; Bonsignore, L.; et al. (2005)
Planta Medica
Immunomodulatory Lipids in Plants: Plant Fatty Acid Amides and the Human Endocannabinoid System
Gertsch, Jürg (2008)
Planta Medica
Since the discovery that endogenous lipid mediators show similar cannabimimetic effects as phytocannabinoids from Cannabis sativa, our knowledge about the endocannabinoid system has rapidly expanded. Today, endocannabinoid action is known to be involved in various diseases, including inflammation and pain. As a consequence, the G-protein coupled cannabinoid receptors, endocannabinoid transport, as well as endocannabinoid metabolizing enzymes represent targets to block or enhance cannabinoid receptor-mediated signalling for therapeutic intervention. Based on the finding that certain endocannabinoid-like fatty acid N-alkylamides from purple coneflower (Echinacea spp.) potently activate CB2 cannabinoid receptors we have focused our interest on plant fatty acid amides (FAAs) and their overall cannabinomodulatory effects. Certain FAAs are also able to partially inhibit the action of fatty acid amide hydrolase (FAAH), which controls the breakdown of endocannabinoids. Intriguingly, plants lack CB receptors and do not synthesize endocannabinoids, but express FAAH homologues capable of metabolizing plant endogenous N-acylethanolamines (NAEs). While the site of action of these NAEs in plants is unknown, endogenous NAEs and arachidonic acid glycerols in animals interact with distinct physiological lipid receptors, including cannabinoid receptors. There is increasing evidence that also plant FAAs other than NAEs can pharmacologically modulate the action of these endogenous lipid signals. The interference of plant FAAs with the animal endocannabinoid system could thus be a fortunate evolutionary cross point with yet unexplored therapeutic potential.
Exploration of natural and synthetic N-alkyl amides as source for new cannabinoid receptor type-2 (CB2) selective ligands
Gertsch, J.; Raduner, S.; Chicca, A.; et al. (2007)
Planta Medica
Gingerol derivatives modulate T-cell receptor mediated effects in a whole blood assay and in T-cells via 5-HT1A receptor-dependent mechanisms
Nievergelt, A.; Schoop, R.; Altmann, Karl-Heinz; et al. (2007)
Planta Medica
Linking ethnopharmacology with phenotypic and virtual screening for the identification of antiviral agents from natural sources
Mair, C. E.; Grienke, U.; Draschl, C.; et al. (2014)
Planta Medica
Albert Hofmann (1906 – 2008)
Sticher, Otto; Hamburger, Matthias (2008)
Planta Medica
Falcarinol (Panaxynol) is a C131 cannabinoid receptor antagonist and induces pro-allergic effects in skin
Gertsch, Jürg; Leonti, Marco; Casu, Laura; et al. (2009)
Planta Medica

Publications 1 - 10 of 28

Journal: Planta Medica

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