Journal: Trends in Cell Biology

Abbreviation

Trends cell biol. (Regul. ed.)

Publisher

Elsevier

Journal Volumes

ISSN

0962-8924
0968-0039
1879-3088

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Publications 1 - 10 of 24
  • Spindle asymmetry
    Item type: Review Article
    Kusch, Justine; Liakopoulos, Dimitris; Barral, Yves (2003)
    Trends in Cell Biology
  • Leucine-rich nuclear-export signals
    Item type: Journal Article
    Kutay, Ulrike; Güttinger, Stephan (2005)
    Trends in Cell Biology
  • Polarizing without a C(I)ue
    Item type: Review Article
    Sohrmann, Marc; Matthias, Peter (2003)
    Trends in Cell Biology
  • Atomic force microscopy
    Item type: Review Article
    Müller, Daniel J.; Dufrêne, Yves F. (2011)
    Trends in Cell Biology
  • The peroxisome: an up-and-coming organelle in immunometabolism
    Item type: Review Article
    Di Cara, Francesca; Savary, Stéphane; Kovacs, Werner; et al. (2023)
    Trends in Cell Biology
    Peroxisomes are essential metabolic organelles, well known for their roles in the metabolism of complex lipids and reactive ionic species. In the past 10 years, peroxisomes have also been cast as central regulators of immunity. Lipid metabolites of peroxisomes, such as polyunsaturated fatty acids (PUFAs), are precursors for important immune mediators, including leukotrienes (LTs) and resolvins. Peroxisomal redox metabolism modulates cellular immune signaling such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Additionally, peroxisomal β-oxidation and ether lipid synthesis control the development and aspects of the activation of both innate and adaptive immune cells. Finally, peroxisome number and metabolic activity have been linked to inflammatory diseases. These discoveries have opened avenues of investigation aimed at targeting peroxisomes for therapeutic intervention in immune disorders, inflammation, and cancer.
  • Hsp90@chromatin.nucleus
    Item type: Review Article
    Sawarkar, Ritwick; Paro, Renato (2013)
    Trends in Cell Biology
  • Centrosome heterogeneity in stem cells regulates cell diversity
    Item type: Review Article
    Camargo Ortega, Germán; Götz, Magdalena (2022)
    Trends in Cell Biology
    Stem cells are at the source of creating cellular diversity. Multiple mechanisms, including basic cell biological processes, regulate their fate. The centrosome is at the core of many stem cell functions and recent work highlights the association of distinct proteins at the centrosome in stem cell differentiation. As showcased by a novel centrosome protein regulating neural stem cell differentiation, it is timely to review the heterogeneity of the centrosome at protein and RNA levels and how this impacts their function in stem and progenitor cells. Together with evidence for heterogeneity of other organelles so far considered as similar between cells, we call for exploring the cell type-specific composition of organelles as a way to expand protein function in development with relevance to regenerative medicine.
  • Telomere functions grounding on TERRA firma
    Item type: Journal Article
    Azzalin, Claus M.; Lingner, Joachim (2015)
    Trends in Cell Biology
  • MSI1-like proteins
    Item type: Review Article
    Hennig, Lars; Bouveret, Romaric; Gruissem, Wilhelm (2005)
    Trends in Cell Biology
  • Mitotic disassembly and reassembly of nuclear pore complexes
    Item type: Review Article
    Kutay, Ulrike; Jühlen, Ramona; Antonin, Wolfram (2021)
    Trends in Cell Biology
    Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope (NE) that serve as selective gates for macromolecular transport between nucleus and cytoplasm. When higher eukaryotic cells prepare for division, they rapidly disintegrate NPCs during NE breakdown such that nuclear and cytoplasmic components mix to enable the formation of a cytoplasmic mitotic spindle. At the end of mitosis, reassembly of NPCs is coordinated with the establishment of the NE around decondensing chromatin. We review recent progress on mitotic NPC disassembly and reassembly, focusing on vertebrate cells. We highlight novel mechanistic insights into how NPCs are rapidly disintegrated into conveniently reusable building blocks, and put divergent models of (post-)mitotic NPC assembly into a spatial and temporal context.
Publications 1 - 10 of 24